5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- Product Name
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- CAS No.
- 881674-56-2
- Chemical Name
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- Synonyms
- 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde;Vonorazan;VONOPRAZAN IST-1;5-(2-FL;e-3-carbaL;)-1H-pyrroL;Vonoprazan-1;Vonoprazan-023
- CBNumber
- CB52638918
- Molecular Formula
- C11H8FNO
- Formula Weight
- 189.19
- MOL File
- 881674-56-2.mol
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Property
- Melting point:
- 133 °C
- Boiling point:
- 370.6±32.0 °C(Predicted)
- Density
- 1.270±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.77±0.50(Predicted)
- color
- Light Brown to Brown
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C11H8FNO/c12-10-4-2-1-3-9(10)11-5-8(7-14)6-13-11/h1-7,13H
- InChIKey
- MQULPEUCGKEHEG-UHFFFAOYSA-N
- SMILES
- N1C(C2=CC=CC=C2F)=CC(C=O)=C1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- F1074
- Product name
- 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $98
- Updated
- 2024/03/01
- Product number
- F1074
- Product name
- 5-(2-Fluorophenyl)pyrrole-3-carboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $295
- Updated
- 2024/03/01
- Product number
- F489655
- Product name
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- F489655
- Product name
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-W004473
- Product name
- 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde
- Purity
- 99.96%
- Packaging
- 10g
- Price
- $67
- Updated
- 2021/12/16
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties,Usage,Production
Description
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is an ether. It can be used to prepare vonoprazan fumarate, which is a potent orally active potassium-competitive acid blocker (P-CAB) with antisecretory activity. It is used in the study of acid-related diseases.
Chemical Properties
Light orange to Yellow to Green powder to crystal.
Uses
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
Application
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
Preparation
Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.
Definition
The 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde is an important intermediate of Voranolan fumarate, a competitive potassium ion acid blocker. Voranolan fumarate treats gastric ulcers, duodenal ulcers, reflux esophagitis, etc. 5-(2-fluorophenyl) -1H-pyrrole-3-formaldehyde can be synthesized in one pot using 2-(2-fluorobenzoyl)malononitrile as raw material.
Hazard
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde has acute toxin effects and is a skin and eye irritant.
5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde manufacturers
- Product
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2
- Price
- US $1110.00-1000.00/kilograms
- Min. Order
- 1kilograms
- Purity
- 99.95%
- Supply Ability
- 100tons
- Release date
- 2023-02-14
- Product
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 881674-56-2
- Price
- US $50.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 1000
- Release date
- 2024-03-20
- Product
- 5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde 881674-56-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2022-02-17