3-Quinolinecarboxylic acid, 6-broMo-, Methyl ester
- Product Name
- 3-Quinolinecarboxylic acid, 6-broMo-, Methyl ester
- CAS No.
- 1220418-77-8
- Chemical Name
- 3-Quinolinecarboxylic acid, 6-broMo-, Methyl ester
- Synonyms
- Methyl 6-broMoquinoline-3-carboxylate;Methyl 6-bromo-3-quinolinecarboxylate;6-bromoquinoline-3-carboxylic acid methyl ester;Methyl6-bromoquinoline-3-carboxylate,95%,QY-1716;3-Quinolinecarboxylic acid, 6-broMo-, Methyl ester
- CBNumber
- CB52642308
- Molecular Formula
- C11H8BrNO2
- Formula Weight
- 266.09
- MOL File
- 1220418-77-8.mol
3-Quinolinecarboxylic acid, 6-broMo-, Methyl ester Property
- Boiling point:
- 348.5±22.0 °C(Predicted)
- Density
- 1.557±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.30±0.14(Predicted)
N-Bromosuccinimide Price
- Product number
- M296308
- Product name
- Methyl6-bromoquinoline-3-carboxylate
- Packaging
- 25mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- Z8583
- Product name
- Methyl6-bromoquinoline-3-carboxylate
- Packaging
- 1g
- Price
- $802
- Updated
- 2021/12/16
- Product number
- CM145493
- Product name
- methyl6-bromoquinoline-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $1658
- Updated
- 2021/12/16
- Product number
- 1220418778
- Product name
- Methyl6-bromoquinoline-3-carboxylate
- Packaging
- 5g
- Price
- $1705.89
- Updated
- 2021/12/16
- Product number
- 61-10236
- Product name
- Methyl6-bromoquinoline-3-carboxylate
- Purity
- 95-98%
- Packaging
- 5g
- Price
- $1755
- Updated
- 2021/12/16
3-Quinolinecarboxylic acid, 6-broMo-, Methyl ester Chemical Properties,Usage,Production
Synthesis
67-56-1
798545-30-9
1220418-77-8
Example 1: Synthesis of tert-butyl {3-[(hydroxyamino)carbonyl]quinolin-6-yl}carbamate (Compound 1-21, Int-2) Step 1: Synthesis of methyl 6-bromoquinoline-3-carboxylate (Intermediate 1) [00161] To a solution of 6-bromoquinoline-3-carboxylic acid (3 g, 11.9 mmol) in methanol (55 mL) was slowly added concentrated sulfuric acid (0.32 mL, 6 mmol). The reaction mixture was stirred and refluxed at 85 °C for 96 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 7 by slow addition of saturated sodium bicarbonate solution.During neutralization, methyl 6-bromoquinoline-3-carboxylate precipitated as a solid, which was collected by filtration (Intermediate 1, 2.77 g, 97% yield). Product Characterization: LC-MS (FA) ES+ m/z: 266 [M+H]+. 1H NMR (400 MHz, DMSO-d6) δ ppm: 9.33 (d, J = 2.1 Hz, 1H), 9.01 (d, J = 2.1 Hz, 1H), 8.53 (t, J = 1.3 Hz, 1H), 8.07-8.01 (m, 2H), 3.95 (s, 3H).
References
[1] Patent: WO2011/146591, 2011, A1. Location in patent: Page/Page column 60
[2] Patent: WO2014/86697, 2014, A1. Location in patent: Page/Page column 46-47
3-Quinolinecarboxylic acid, 6-broMo-, Methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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