ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE
- Product Name
- ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE
- CAS No.
- 481054-89-1
- Chemical Name
- ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE
- Synonyms
- ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE;6-BroMoquinoline-3-carboxylic acid ethyl ester;3-Quinolinecarboxylic acid, 6-bromo-, ethyl ester
- CBNumber
- CB02465054
- Molecular Formula
- C12H10BrNO2
- Formula Weight
- 280.12
- MOL File
- 481054-89-1.mol
ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E900820
- Product name
- Ethyl6-bromoquinoline-3-carboxylate
- Packaging
- 1g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- CS-0061591
- Product name
- Ethyl6-bromoquinoline-3-carboxylate
- Purity
- 99.12%
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
- Product number
- CS-0061591
- Product name
- Ethyl6-bromoquinoline-3-carboxylate
- Purity
- 99.12%
- Packaging
- 5g
- Price
- $448
- Updated
- 2021/12/16
- Product number
- CS-0061591
- Product name
- Ethyl6-bromoquinoline-3-carboxylate
- Purity
- 99.12%
- Packaging
- 10g
- Price
- $780
- Updated
- 2021/12/16
- Product number
- 3261AQ
- Product name
- ETHYL6-BROMOQUINOLINE-3-CARBOXYLATE
- Packaging
- 5g
- Price
- $1146.8
- Updated
- 2021/12/16
ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
10601-80-6
20357-20-4
481054-89-1
Step 1: Synthesis of ethyl 6-bromoquinoline-3-carboxylate To a solution of 5-bromo-2-nitrobenzaldehyde (2 g, 9 mmol) in ethanol (46 mL) was sequentially added tin(II) chloride dihydrate (7.95 g, 35.2 mmol) and ethyl 3,3-diethoxypropionate (4.2 mL, 22 mmol). The reaction mixture was heated to 90 °C and maintained for 16 hours. Upon completion of the reaction, it was cooled to room temperature and stirring was continued overnight. Subsequently, the reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The solution was poured into a saturated aqueous sodium bicarbonate solution to form an emulsion. The emulsion was filtered through diatomaceous earth and the diatomaceous earth was rinsed with ethyl acetate. The organic and aqueous layers were separated and the aqueous phase was further extracted with ethyl acetate. All organic phases were combined, washed with brine, dried over magnesium sulfate, filtered and concentrated. Finally, purification by fast column chromatography (eluent: 0-50% ethyl acetate/heptane gradient) gave ethyl 6-bromoquinoline-3-carboxylate (1.41 g, 60% yield) as a solid.
References
[1] Journal of Organic Chemistry, 2010, vol. 75, # 10, p. 3488 - 3491
[2] Patent: US2012/270893, 2012, A1. Location in patent: Page/Page column 32
ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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