ChemicalBook > CAS DataBase List > ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE

ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE

Product Name: ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE
CAS No.: 481054-89-1
Chemical Name: ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE
Synonyms: ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE;6-BroMoquinoline-3-carboxylic acid ethyl ester;3-Quinolinecarboxylic acid, 6-bromo-, ethyl ester
CBNumber: CB02465054
Molecular Formula: C12H10BrNO2
Formula Weight: 280.12
MOL File: 481054-89-1.mol

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ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE Property

storage temp.: Sealed in dry,Room Temperature
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E900820
Product name: Ethyl6-bromoquinoline-3-carboxylate
Packaging: 1g
Price: $415
Updated: 2021/12/16

ChemScene

Product number: CS-0061591
Product name: Ethyl6-bromoquinoline-3-carboxylate
Purity: 99.12%
Packaging: 5g
Price: $448
Updated: 2021/12/16

ChemScene

Product number: CS-0061591
Product name: Ethyl6-bromoquinoline-3-carboxylate
Purity: 99.12%
Packaging: 1g
Price: $112
Updated: 2021/12/16

AK Scientific

Product number: 3261AQ
Product name: ETHYL6-BROMOQUINOLINE-3-CARBOXYLATE
Packaging: 5g
Price: $1146.8
Updated: 2021/12/16

ChemScene

Product number: CS-0061591
Product name: Ethyl6-bromoquinoline-3-carboxylate
Purity: 99.12%
Packaging: 10g
Price: $780
Updated: 2021/12/16

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ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

10601-80-6

20357-20-4

481054-89-1

Step 1: Synthesis of ethyl 6-bromoquinoline-3-carboxylate To a solution of 5-bromo-2-nitrobenzaldehyde (2 g, 9 mmol) in ethanol (46 mL) was sequentially added tin(II) chloride dihydrate (7.95 g, 35.2 mmol) and ethyl 3,3-diethoxypropionate (4.2 mL, 22 mmol). The reaction mixture was heated to 90 °C and maintained for 16 hours. Upon completion of the reaction, it was cooled to room temperature and stirring was continued overnight. Subsequently, the reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The solution was poured into a saturated aqueous sodium bicarbonate solution to form an emulsion. The emulsion was filtered through diatomaceous earth and the diatomaceous earth was rinsed with ethyl acetate. The organic and aqueous layers were separated and the aqueous phase was further extracted with ethyl acetate. All organic phases were combined, washed with brine, dried over magnesium sulfate, filtered and concentrated. Finally, purification by fast column chromatography (eluent: 0-50% ethyl acetate/heptane gradient) gave ethyl 6-bromoquinoline-3-carboxylate (1.41 g, 60% yield) as a solid.

References

[1] Journal of Organic Chemistry, 2010, vol. 75, # 10, p. 3488 - 3491
[2] Patent: US2012/270893, 2012, A1. Location in patent: Page/Page column 32

ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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481054-89-1, ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATERelated Search:

3-Quinolinecarboxylic acid, 6-broMo-, Methyl ester 6-BroMoquinoline-2-carbaldehyde 6-BROMOQUINOLINE-3-CARBOXYLIC ACID 3-Quinolinecarboxaldehyde, 6-broMo- 6-BroMoquinolin-3-aMine 6-Bromogramine 6-bromoquinoxalin-2(1H)-one 6-Hydroxyquinoline

6-BroMoquinoline-3-carboxylic acid ethyl ester

ETHYL 6-BROMOQUINOLINE-3-CARBOXYLATE

3-Quinolinecarboxylic acid, 6-bromo-, ethyl ester

481054-89-1