NVP-BVU 972
- Product Name
- NVP-BVU 972
- CAS No.
- 1185763-69-2
- Chemical Name
- NVP-BVU 972
- Synonyms
- CS-529;NVP-BVU972;NVP-BVU 972;NVP-BVU972, >=98%;NVP-BVU 972 USP/EP/BP;NVP-BVU972;NVP-BVU 972;6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline;Quinoline, 6-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]-;6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline NVP-BVU972
- CBNumber
- CB52645147
- Molecular Formula
- C20H16N6
- Formula Weight
- 340.38
- MOL File
- 1185763-69-2.mol
NVP-BVU 972 Property
- Density
- 1.35
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥17 mg/mL in DMSO; ≥25.15 mg/mL in EtOH
- form
- solid
- pka
- 4.92±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N925800
- Product name
- NVP-BVU972
- Packaging
- 50mg
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- 66487
- Product name
- NVP-BVU972
- Packaging
- 5mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- KIN0001410
- Product name
- BVU-972
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $876.65
- Updated
- 2021/12/16
- Product number
- KIN0001410
- Product name
- BVU-972
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1807.58
- Updated
- 2021/12/16
- Product number
- CS-0967
- Product name
- NVP-BVU972
- Purity
- 98.38%
- Packaging
- 50mg
- Price
- $1020
- Updated
- 2021/12/16
NVP-BVU 972 Chemical Properties,Usage,Production
Uses
NVP-BVU972 exhibits strong inhibition towards MET kinase but displays low inhibition against other kinases including the most closely related kinase RON.
Biological Activity
nvp-bvu972 is a selective and potent inhibitor of c-met with ic50 of 14 nm. besides, nvp-bvu972 displays ic50 values more than 1000 nm in other kinases such as the most closely related kinase recepteur d'origine nantais (ron).c-met, also known as hepatocyte growth factor receptor, is a receptor tyrosine kinase that can be activated by hepatocyte growth factor/scatter factor (hgf/sf). it is a membrane protein which plays an essential role in embryonic development and wound healing.in the ebc-1, gtl-16, and mkn-45 human cancer cells, nvp-bvu972 potently inhibits the cell proliferation with ic50 values of 82, 66 and 32 nm, respectively. additionally, nvp-bvu972 treatment leads to the inhibition of the growth of the transformed mouse baf3 cells containing tpr-met kinase fusions with ic50 of 104 nm 1.in human sample, nvp-bvu972 treatment on cells expressing wild-type tpr-met resulted in a dose-dependent reduction in tpr-met phosphorylation. y1230h, d1228a, f1200i and l1195v mutations abrogate the tpr-met phosphorylation inhibition effect of nvp-bvu972 in baf3 tpr-met1.
target
Met
References
1. tiedt r, degenkolbe e, furet p, et al. a drug resistance screen using a selective met inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. cancer research. 2011;71(15):5255-5264.
NVP-BVU 972 Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-BVU 972 Suppliers
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View Lastest Price from NVP-BVU 972 manufacturers
- Product
- NVP-BVU972 1185763-69-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10