NVP-BVU 972

Product Name: NVP-BVU 972
CAS No.: 1185763-69-2
Chemical Name: NVP-BVU 972
Synonyms: CS-529;NVP-BVU972;NVP-BVU 972;NVP-BVU972, >=98%;NVP-BVU 972 USP/EP/BP;NVP-BVU972;NVP-BVU 972;NVP-BVU972, 10 mM in DMSO;6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline;Quinoline, 6-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]-;6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline NVP-BVU972
CBNumber: CB52645147
Molecular Formula: C20H16N6
Formula Weight: 340.38
MOL File: 1185763-69-2.mol

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NVP-BVU 972 Property

Density: 1.35
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥17 mg/mL in DMSO; ≥25.15 mg/mL in EtOH
form: solid
pka: 4.92±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: N925800
Product name: NVP-BVU972
Packaging: 50mg
Price: $1050
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 66487
Product name: NVP-BVU972
Packaging: 5mg
Price: $750
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001410
Product name: BVU-972
Purity: 95.00%
Packaging: 1MG
Price: $876.65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001410
Product name: BVU-972
Purity: 95.00%
Packaging: 5G
Price: $1807.58
Updated: 2021/12/16

ChemScene

Product number: CS-0967
Product name: NVP-BVU972
Purity: 98.38%
Packaging: 50mg
Price: $1020
Updated: 2021/12/16

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NVP-BVU 972 Chemical Properties,Usage,Production

Uses

NVP-BVU972 exhibits strong inhibition towards MET kinase but displays low inhibition against other kinases including the most closely related kinase RON.

Biological Activity

nvp-bvu972 is a selective and potent inhibitor of c-met with ic50 of 14 nm. besides, nvp-bvu972 displays ic50 values more than 1000 nm in other kinases such as the most closely related kinase recepteur d'origine nantais (ron).c-met, also known as hepatocyte growth factor receptor, is a receptor tyrosine kinase that can be activated by hepatocyte growth factor/scatter factor (hgf/sf). it is a membrane protein which plays an essential role in embryonic development and wound healing.in the ebc-1, gtl-16, and mkn-45 human cancer cells, nvp-bvu972 potently inhibits the cell proliferation with ic50 values of 82, 66 and 32 nm, respectively. additionally, nvp-bvu972 treatment leads to the inhibition of the growth of the transformed mouse baf3 cells containing tpr-met kinase fusions with ic50 of 104 nm 1.in human sample, nvp-bvu972 treatment on cells expressing wild-type tpr-met resulted in a dose-dependent reduction in tpr-met phosphorylation. y1230h, d1228a, f1200i and l1195v mutations abrogate the tpr-met phosphorylation inhibition effect of nvp-bvu972 in baf3 tpr-met1.

target

Met

References

1. tiedt r, degenkolbe e, furet p, et al. a drug resistance screen using a selective met inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. cancer research. 2011;71(15):5255-5264.

NVP-BVU 972 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-BVU 972 Suppliers

Canada 1 China 75 India 2 United Kingdom 1 United States 15 Global 94

MedChemexpress LLC

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Target molecule Corp.

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Musechem

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InvivoChem

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Cckinase, Inc.

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Aladdin Scientific

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Selleck Chemicals LLC

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View Lastest Price from NVP-BVU 972 manufacturers

Career Henan Chemical Co

Product: NVP-BVU972 1185763-69-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

1185763-69-2, NVP-BVU 972Related Search:

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6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline NVP-BVU972

NVP-BVU 972

NVP-BVU972

6-[[6-(1-Methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline

NVP-BVU972, >=98%

NVP-BVU972;NVP-BVU 972

CS-529

Quinoline, 6-[[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]-

NVP-BVU 972 USP/EP/BP

NVP-BVU972, 10 mM in DMSO

1185763-69-2

Inhibitors