AG 7352 Hydrochloride

Product Name: AG 7352 Hydrochloride
CAS No.: 175519-16-1
Chemical Name: AG 7352 Hydrochloride
Synonyms: SNS-595 Hydrochloride;AG 7352 Hydrochloride;Voreloxin (SNS-595) HCl;Vosaroxin Hydrochloride;Voreloxin (Hydrochloride);Vosaroxin hydrochloride salt;Voreloxin 13C-D3 Hydrochloride;Voreloxin(SNS-595)hydrochloride;Vosaroxin hydrochloride >=98% (HPLC);Voreloxin Impurity 1 (Hydrochloride)
CBNumber: CB52645152
Molecular Formula: C18H20ClN5O4S
Formula Weight: 437.9
MOL File: 175519-16-1.mol

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AG 7352 Hydrochloride Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: White to gray
optical activity: [α]/D +42 to +52°, c =1 in 0.1 M NaOH
Water Solubility: H2O: 1mg/mL, clear (warmed)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0927
Product name: VoreloxinHydrochloride
Purity: 99.96%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0927
Product name: VoreloxinHydrochloride
Purity: 99.96%
Packaging: 10mg
Price: $210
Updated: 2021/12/16

ApexBio Technology

Product number: A3925
Product name: VoreloxinHydrochloride
Packaging: 5mg
Price: $221
Updated: 2021/12/16

ApexBio Technology

Product number: A3925
Product name: VoreloxinHydrochloride
Packaging: 10mg
Price: $378
Updated: 2021/12/16

ChemScene

Product number: CS-0927
Product name: VoreloxinHydrochloride
Purity: 99.96%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

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AG 7352 Hydrochloride Chemical Properties,Usage,Production

Uses

Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

Biological Activity

Voreloxin hydrochloride (SNS-595, Vosaroxin) is a potent Topoisomerase II inhibitor with broad-spectrum antitumor activity. Phase 2.

in vivo

Voreloxin (20 mg/kg, i.v.) alone results in 80% reduction in bone marrow cellularity of CD-1 mice by administration one dose every 4 days repeated twice (q4d ×2). voreloxin at 10 mg/kg in combination with cytarabine causes ablation of the marrow, dilation of sinusoids, and infiltration of adipocytes in mice. Voreloxin (20 mg/kg, i.v.) combined with cytarabine causes a reversible decrease in myeloid and lymphoid cells in bone marrow and peripheral blood CD-1 mice. voreloxin (10 mg/kg, q4d ×2) and cytarabine in combination causes reversible neutropenia with a more modest impact on platelets CD-1 mice^[2].

target

Target	Value
Topo II

IC 50

Topoisomerase II

References

[1] Hotinski AK, et al. Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia. Expert Opin Pharmacother. 2015 Jun;16(9):1395-402. DOI:10.1517/14656566.2015.1044437
[2] Scatena CD, et al. Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8. DOI:10.1007/s00280-009-1234-z
[3] Walsby EJ, et al. The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine. Haematologica. 2011 Mar;96(3):393-9. DOI:10.3324/haematol.2010.032680

AG 7352 Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 7352 Hydrochloride Suppliers

China 68 India 1 United States 8 Global 77

Shanghai Boyle Chemical Co., Ltd.

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Dalian Meilun Biotech Co., Ltd.

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Email: sales@meilune.com
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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MedChemexpress LLC

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Country: United States
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Sichuan Wei Keqi Biological Technology Co., Ltd.

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LETOPHARM LIMITED

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Shanghai Lollane Biological Technology Co.,Ltd.

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Fax: +86-21-52996696
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SPIRO PHARMA

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Shanghai EFE Biological Technology Co., Ltd.

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Email: info@efebio.com
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Guangzhou QiYun Biotechnology Co., Ltd.

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Fax: 020-61288700
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175519-16-1, AG 7352 HydrochlorideRelated Search:

AG 7352 Hydrochloride

SNS-595 Hydrochloride

Voreloxin (Hydrochloride)

Vosaroxin Hydrochloride

(3S-trans)-1,4-Dihydro-7-[3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid monohydrochloride

Voreloxin (SNS-595) HCl

SNS-595 HYDROCHLORIDE; VOSAROXIN HYDROCHLORIDE; AG 7352 HYDROCHLORIDE

Voreloxin(SNS-595)hydrochloride

1,8-Naphthyridine-3-carboxylic Acid, 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-, monohydrochloride

Vosaroxin hydrochloride >=98% (HPLC)

Vosaroxin hydrochloride salt

Voreloxin 13C-D3 Hydrochloride

AG 7352,Apoptosis,AG7352,Inhibitor,SNS595,inhibit,AG-7352,Voreloxin hydrochloride,SNS-595,Voreloxin,SNS 595,Topoisomerase

VoreloxinHydrochloride/AG-7352Hydrochloride

Voreloxin Impurity 1 (Hydrochloride)

7-((3S,4S)-3-Methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid hydrochloride , Voreloxin HCl

7-((3S,4S)-3-Methoxy-4-(methylamino)pyrrolidin-1-yl)-4-oxo-1-(thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid hydrochloride

Voreloxin hydrochloride, 10 mM in DMSO

Voreloxin (SNS-595) hydrochloride ，S7518

175519-16-1

C18H20ClN5O4S

C18H19N5O4SHCl