5-broMo-2-chloro-6-Methylpyridin-3-aMine
- Product Name
- 5-broMo-2-chloro-6-Methylpyridin-3-aMine
- CAS No.
- 1198319-36-6
- Chemical Name
- 5-broMo-2-chloro-6-Methylpyridin-3-aMine
- Synonyms
- 5-broMo-2-chloro-6-Methylpyridin-3-aMine;2-Chloro-3-amine-5-bromo-6-methylpyridine;5-Bromo-2-chloro-6-methyl-pyridin-3-ylamine
- CBNumber
- CB52645187
- Molecular Formula
- C6H6BrClN2
- Formula Weight
- 221.48
- MOL File
- 1198319-36-6.mol
5-broMo-2-chloro-6-Methylpyridin-3-aMine Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B124965
- Product name
- Ethyl5,7-Dimethylimidazo[1,2-a]pyrimidine-2-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A358149
- Product name
- 5-Bromo-2-chloro-6-methylpyridin-3-amine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- A358149
- Product name
- 5-Bromo-2-chloro-6-methylpyridin-3-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $179
- Updated
- 2021/12/16
- Product number
- CM248120
- Product name
- 5-Bromo-2-chloro-6-methylpyridin-3-amine
- Purity
- 97%
- Packaging
- 5g
- Price
- $196
- Updated
- 2021/12/16
- Product number
- CM248120
- Product name
- 5-Bromo-2-chloro-6-methylpyridin-3-amine
- Purity
- 97%
- Packaging
- 10g
- Price
- $297
- Updated
- 2021/12/16
5-broMo-2-chloro-6-Methylpyridin-3-aMine Chemical Properties,Usage,Production
Synthesis
186413-75-2
1198319-36-6
General procedure for the synthesis of 5-bromo-2-chloro-6-methylpyridin-3-amine from 2-chloro-3-nitro-5-bromo-6-methylpyridine: In a 250 mL round-bottomed flask, 3-bromo-6-chloro-2-methyl-5-nitropyridine (1.5 g, 5.97 mmol, commercially available) was added and dissolved in ethyl acetate (20 mL). To this solution was added ammonium chloride (3.19 g, 59.65 mmol) dissolved in water (10 mL) and stirred for 10 minutes at room temperature. Zinc powder (2.340 g, 35.79 mmol) was then quickly added and the resulting reaction mixture was refluxed at 55°C for 6 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and concentrated in vacuum. The residue was partitioned between ethyl acetate (150 mL) and water (75 mL). The organic layer was dried with anhydrous sodium sulfate and subsequently concentrated under vacuum. The crude product was purified by fast column chromatography using an Argonaut purification system to afford 5-bromo-2-chloro-6-methylpyridin-3-amine (0.500 g, 37.8% yield) as a white solid using a hexane solution of 12% ethyl acetate as eluent. Mass spectrum (ES+): m/z 222, molecular formula C6H6BrClN2.
References
[1] Patent: WO2009/147431, 2009, A1. Location in patent: Page/Page column 52; 53
5-broMo-2-chloro-6-Methylpyridin-3-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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