1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene
- Product Name
- 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene
- CAS No.
- 170098-88-1
- Chemical Name
- 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene
- Synonyms
- 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene;Benzene, 1-chloro-4-fluoro-2-methyl-5-nitro-
- CBNumber
- CB52645415
- Molecular Formula
- C7H5ClFNO2
- Formula Weight
- 189.57
- MOL File
- 170098-88-1.mol
1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene Property
- storage temp.
- 2-8°C
- Appearance
- Light brown to yellow Solid-Liquid Mixture
Safety
- HS Code
- 2904990090
N-Bromosuccinimide Price
- Product number
- C585020
- Product name
- 1-Chloro-4-fluoro-2-methyl-5-nitrobenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C585020
- Product name
- 1-Chloro-4-fluoro-2-methyl-5-nitrobenzene
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC900714
- Product name
- 1-Chloro-4-fluoro-2-methyl-5-nitrobenzene
- Purity
- 97%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- PC900714
- Product name
- 1-Chloro-4-fluoro-2-methyl-5-nitrobenzene
- Purity
- 97%
- Packaging
- 5g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 8715AA
- Product name
- 1-Chloro-4-fluoro-2-methyl-5-nitrobenzene
- Packaging
- 5g
- Price
- $249
- Updated
- 2021/12/16
1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene Chemical Properties,Usage,Production
Synthesis
33406-96-1
170098-88-1
The general procedure for the synthesis of 2-chloro-5-fluoro-4-nitrotoluene from 2-chloro-5-fluorotoluene was as follows: to a stirred concentrated solution of 2-chloro-5-fluorotoluene (0.500 g, 3.46 mmol, Lancaster, for direct use) was added H2SO4 (5.0 mL) slowly at 0 °C. Subsequently, KNO3 (0.350 g, 3.46 mmol) was added all at once. The reaction mixture was gradually warmed to 28 °C and stirred at this temperature overnight. Upon completion of the reaction, the mixture was quenched by pouring it into ice (50 g) and extracted with ether (2 x 50 mL). The combined ether layers were dried with anhydrous Na2SO4 and subsequently concentrated under reduced pressure to remove the solvent. The obtained oily product was further dried under vacuum to give 0.616 g (94% yield) of 2-chloro-5-fluoro-4-nitrotoluene as an oil, which was used directly in the subsequent reaction.1H NMR (CDCl3) data were as follows: δ 2.459 (s, 3H), 7.193 (d, 1H, J=11.1 Hz), 8.083 (d, 1H, J= 6.6Hz).
References
[1] Patent: WO2007/107566, 2007, A1. Location in patent: Page/Page column 45
[2] Patent: WO2007/36718, 2007, A2. Location in patent: Page/Page column 53
[3] Patent: WO2008/119721, 2008, A1. Location in patent: Page/Page column 60
[4] Journal of Organic Chemistry, 1995, vol. 60, # 18, p. 5838 - 5842
[5] Patent: US5631373, 1997, A
1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene manufacturers
- Product
- 1-Chloro-4-fluoro-2-Methyl-5-nitrobenzene 170098-88-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-13