(R)-Piperidin-2-ylMethanol
- Product Name
- (R)-Piperidin-2-ylMethanol
- CAS No.
- 3197-44-2
- Chemical Name
- (R)-Piperidin-2-ylMethanol
- Synonyms
- (R)-2-Piperidylmethanol;(2R)-2-Piperidinemethanol;(R)-Piperidin-2-ylMethanol;(R)-Piperidine-2-ylmethanol;2-Piperidinemethanol, (2R)-;[(2R)-piperidin-2-yl]methanol;(R)-2-HYDROXYMETHYLPIPERIDINE;(R)-piperidin-2-ylmethanol hydrochloride
- CBNumber
- CB52648496
- Molecular Formula
- C6H13NO
- Formula Weight
- 115.17
- MOL File
- 3197-44-2.mol
(R)-Piperidin-2-ylMethanol Property
- Boiling point:
- 98-102 °C(Press: 1.0 Torr)
- Density
- 0.951±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 15.08±0.10(Predicted)
- Appearance
- Colorless to off-white Solid-Liquid Mixture
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CCH0031959
- Product name
- ((R)-PIPERIDIN-2-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $249.9
- Updated
- 2021/12/16
- Product number
- Z4592
- Product name
- (R)-Piperidin-2-ylmethanol
- Packaging
- 10g
- Price
- $401
- Updated
- 2021/12/16
- Product number
- OR910571
- Product name
- (2R)-piperidin-2-ylmethanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $515
- Updated
- 2021/12/16
- Product number
- J91230
- Product name
- (R)-Piperidin-2-ylmethanol
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CM179494
- Product name
- ((R)-Piperidin-2-yl)methanol
- Purity
- 95%
- Packaging
- 5g
- Price
- $184
- Updated
- 2021/12/16
(R)-Piperidin-2-ylMethanol Chemical Properties,Usage,Production
Synthesis
154499-13-5
3197-44-2
The general procedure for the synthesis of (R)-piperidin-2-ylmethanol from the compound (CAS:154499-13-5) was as follows: carbon-loaded palladium (500 mg, 10 wt%) was added to a solution of benzyl ethyl acetate (70 mL) of (2R)-2-(hydroxymethyl)piperidine-1-carboxylic acid (5.00 g, 20.06 mmol) and stirred at room temperature in a hydrogen atmosphere reaction mixture for 4 hours. Upon completion of the reaction, the mixture was filtered and the filtrate was supplemented with new carbon-loaded palladium catalyst (300 mg). The reaction was continued with stirring under hydrogen atmosphere for 3 hours. The reaction mixture was filtered again and the filtrate was evaporated to give a brown oily crude product. The crude product was purified by Kugelrohr distillation to give the final (2R)-piperidin-2-ylmethanol (1.51 g, 65% yield). The product was characterized by 1H NMR (CDCl3) with the following chemical shifts: 3.53-3.48 (m, 1H), 3.36-3.31 (m, 1H), 3.02 (d, 1H), 2.61-2.53 (m, 2H), 2.35 (s, 2H), 1.75-1.73 (m, 1H), 1.56-1.47 (m, 2H). 1.40-1.25 (m, 2H), 1.14-1.03 (m, 1H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 3, p. 809 - 812
[2] Heterocycles, 2003, vol. 60, # 1, p. 57 - 71
[3] Patent: US2010/168143, 2010, A1. Location in patent: Page/Page column 12-13
(R)-Piperidin-2-ylMethanol Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-Piperidin-2-ylMethanol Suppliers
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View Lastest Price from (R)-Piperidin-2-ylMethanol manufacturers
- Product
- (R)-Piperidin-2-ylMethanol 3197-44-2
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-09