21-HYDROXYALLOPREGNANOLONE

Product Name: 21-HYDROXYALLOPREGNANOLONE
CAS No.: 567-02-2
Chemical Name: 21-HYDROXYALLOPREGNANOLONE
Synonyms: TDOC;5α-THDOC;ALLO TH DOC;3α,5α-THDOC;5alpha-THDOC;ALLOTETRAHYDRO DOC;ALLOTETRAHYDROCORTEXONE;1-HYDROXYALLOPREGNANOLONE;21-HYDROXYALLOPREGNANOLONE;ALLOTETRAHYDRO SUBSTANCE 'Q'
CBNumber: CB5265066
Molecular Formula: C21H34O3
Formula Weight: 334.49
MOL File: 567-02-2.mol

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21-HYDROXYALLOPREGNANOLONE Property

Melting point:: >150oC (dec.)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form: Solid
color: White to Off-White

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P2016
Product name: 3α,21-Dihydroxy-5α-pregnan-20-one
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Sigma-Aldrich

Product number: P2016
Product name: 3α,21-Dihydroxy-5α-pregnan-20-one
Purity: ≥95%
Packaging: 10mg
Price: $198.8
Updated: 2024/03/01

Cayman Chemical

Product number: 28364
Product name: THDOC
Packaging: 500μg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 28364
Product name: THDOC
Packaging: 1mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 28364
Product name: THDOC
Packaging: 5mg
Price: $263
Updated: 2024/03/01

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21-HYDROXYALLOPREGNANOLONE Chemical Properties,Usage,Production

Uses

3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) has been used:

as an γ-aminobutyric acid type A receptor (γ-GABAA) agonist in voltage-clamp measurements studies in Xenopus oocytes
to test its effect on the spike-wave discharges (SWD) finasteride-treated rats
in electrophysiological studies with dentate granule cells (DGCs) post controlled cortical impact (CCI) -induced brain injury

Definition

ChEBI: 5-alpha-THDOC is a 21-hydroxy steroid.

General Description

3α21-Dihydroxy-5α-pregnan-20-one (THDOC) is a neurosteroid. It is synthesized in a two-step process from deoxycorticosterone (DOC) via 5α-dihydrodeoxycorticosterone (DHDOC) intermediate with enzymes 5α-reductase and 3α-hydroxysteroid oxidoreductase catalyzing these steps respectively.

Biochem/physiol Actions

3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) is a positive allosteric modulator of the γ-aminobutyric acid A receptor (GABAA). By modulating GABAA receptor, THDOC allows sustained hyperpolarization and an increase in chloride influx and membrane conductance in neurons. THDOC, thus modulates neuronal excitability. It possesses anxiolytic, anticonvulsant and sedative properties. The levels of THDOC show variation in different physiological states. A low THDOC level in the mensural phase is speculated to play a role in the pathogenesis of catamenial epilepsy (CE) in women. However, elevated levels are reported in depression. THDOC may have an indirect role in the hypothalamic-pituitary–adrenal (HPA) axis activation during acute stress.

storage

Store at RT

21-HYDROXYALLOPREGNANOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

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21-HYDROXYALLOPREGNANOLONE Suppliers

China 29 India 1 Switzerland 1 United Kingdom 5 United States 14 Global 50

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567-02-2, 21-HYDROXYALLOPREGNANOLONERelated Search:

ALLOPREGNANE-3ALPHA,21-DIOL-20-ONE

ALLOTETRADEOXYCORTICOSTERONE

ALLOTETRAHYDROCORTEXONE

ALLOTETRAHYDRODEOXYCORTICOSTERONE

ALLOTETRAHYDRODESOXYCORTICOSTERONE

ALLOTETRAHYDRO DOC

ALLOTETRAHYDRO SUBSTANCE 'Q'

ALLO TH DOC

5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE

5ALPHA-PREGNANE-3ALPHA,21-DIOL-20-ONE

3ALPHA,21-DIHYDROXY-5ALPHA-PREGNAN-20-ONE

21-HYDROXYALLOPREGNANOLONE

5A-pregnane-3A,21-diol-20-one

5alpha-Pregnan-3alpha,21-diol-20-one-17,21,21-D3

3α,21-dihydroxy-5α-pregnan-20-one

5α-Pregnane-3α,21-diol-20-one

5α-Pregnan-3α,21-diol-20-one-17,21,21-D3

21-Hydroxyallopregnanolone, 5α-Pregnane-3α,21-diol-20-one, 5α-THDOC, Allopregnane-3α,21-diol-20-one, Allotetrahydrodeoxycorticosterone

3β,5α-Tetrahydrodeoxycorticosterone

TDOC

5α-THDOC

Allopregnane-3α,21-diol-20-one

Allotetrahydrodeoxycorticosterone (Solution)

1-HYDROXYALLOPREGNANOLONE

Pregnan-20-one, 3,21-dihydroxy-, (3α,5α)-

"3α,21-Dihydroxy-5a-pregnan-20-one"

5alpha-THDOC

3α,21-Dihydroxy-5α-pregnan-20-one

3α,21Dihydroxy5αpregnan20one,3α,21 Dihydroxy 5α pregnan 20 one

3α,5α-THDOC

5α-PREGNAN-3α, 21-DIOL-20-ONE

567-02-2

C21H31D3O3

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Ligand-Gated Ion Channels

Ion Channels

GABA and Glycine Receptor Modulators