ChemicalBook > CAS DataBase List > 21-HYDROXYALLOPREGNANOLONE

21-HYDROXYALLOPREGNANOLONE

Product Name
21-HYDROXYALLOPREGNANOLONE
CAS No.
567-02-2
Chemical Name
21-HYDROXYALLOPREGNANOLONE
Synonyms
TDOC;5α-THDOC;ALLO TH DOC;3α,5α-THDOC;5alpha-THDOC;ALLOTETRAHYDRO DOC;ALLOTETRAHYDROCORTEXONE;1-HYDROXYALLOPREGNANOLONE;21-HYDROXYALLOPREGNANOLONE;ALLOTETRAHYDRO SUBSTANCE 'Q'
CBNumber
CB5265066
Molecular Formula
C21H34O3
Formula Weight
334.49
MOL File
567-02-2.mol
More
Less

21-HYDROXYALLOPREGNANOLONE Property

Melting point:
>150oC (dec.)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
form 
Solid
color 
White to Off-White
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P2016
Product name
3α,21-Dihydroxy-5α-pregnan-20-one
Purity
≥95%
Packaging
5mg
Price
$283.1
Updated
2025/07/31
Sigma-Aldrich
Product number
P2016
Product name
3α,21-Dihydroxy-5α-pregnan-20-one
Purity
≥95%
Packaging
10mg
Price
$511
Updated
2025/07/31
Cayman Chemical
Product number
28364
Product name
THDOC
Packaging
500μg
Price
$41
Updated
2024/03/01
Cayman Chemical
Product number
28364
Product name
THDOC
Packaging
1mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
28364
Product name
THDOC
Packaging
5mg
Price
$263
Updated
2024/03/01
More
Less

21-HYDROXYALLOPREGNANOLONE Chemical Properties,Usage,Production

Uses

3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) has been used:

  • as an γ-aminobutyric acid type A receptor (γ-GABAA) agonist in voltage-clamp measurements studies in Xenopus oocytes
  • to test its effect on the spike-wave discharges (SWD) finasteride-treated rats
  • in electrophysiological studies with dentate granule cells (DGCs) post controlled cortical impact (CCI) -induced brain injury

Definition

ChEBI: 5-alpha-THDOC is a 21-hydroxy steroid.

General Description

3α21-Dihydroxy-5α-pregnan-20-one (THDOC) is a neurosteroid. It is synthesized in a two-step process from deoxycorticosterone (DOC) via 5α-dihydrodeoxycorticosterone (DHDOC) intermediate with enzymes 5α-reductase and 3α-hydroxysteroid oxidoreductase catalyzing these steps respectively.

Biochem/physiol Actions

3α,21-Dihydroxy-5α-pregnan-20-one (THDOC) is a positive allosteric modulator of the γ-aminobutyric acid A receptor (GABAA). By modulating GABAA receptor, THDOC allows sustained hyperpolarization and an increase in chloride influx and membrane conductance in neurons. THDOC, thus modulates neuronal excitability. It possesses anxiolytic, anticonvulsant and sedative properties. The levels of THDOC show variation in different physiological states. A low THDOC level in the mensural phase is speculated to play a role in the pathogenesis of catamenial epilepsy (CE) in women. However, elevated levels are reported in depression. THDOC may have an indirect role in the hypothalamic-pituitary–adrenal (HPA) axis activation during acute stress.

storage

Store at RT

21-HYDROXYALLOPREGNANOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

21-HYDROXYALLOPREGNANOLONE Suppliers

China 47 India 1 Switzerland 1 United Kingdom 5 United States 14 Global 68
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Nanjing Haolv Biotechnology Co.,Ltd
Tel
025-84622273 17361806303
Email
kexin.zhou@haolvbiotech.com
Country
China
ProdList
3019
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
18108052721
Email
2850505130@qq.com
Country
China
ProdList
5167
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-87569266 +86-17392581500
Fax
029-88380327
Email
1015@dideu.com
Country
China
ProdList
3987
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14081
Advantage
58
Shanghai Hewu Biotechnology Co., LTD
Tel
021-57886085 17317861055
Email
shhebio@126.com
Country
CHINA
ProdList
7974
Advantage
58
Qingdao Tenglong microwave technology co., LTD.
Tel
0532-83818797 18561885118
Email
market@tlwb.com.cn
Country
China
ProdList
3944
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Manhag Testing Technology Co., Ltd
Tel
020-3846 2365 19110442770
Email
458677837@qq.com
Country
China
ProdList
7775
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Foshan Treasure Biotechnology Co., Ltd
Tel
0757-85921206 18520245316
Email
2329783215@qq.com
Country
China
ProdList
12661
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
029-029-81120477 17792793610
Email
1033@dideu.com
Country
China
ProdList
9963
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai klamar Reagent Co., LTD
Tel
4001650900 13817534909
Email
3003940895@qq.com
Country
China
ProdList
10714
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-51600108 13062666369
Email
sales@isotopechem.com
Country
China
ProdList
5000
Advantage
58
Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
Email
info@scrbio.com
Country
China
ProdList
9881
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
Advantage
58
Shanghai Beiwanta Biotechnology Co., Ltd.
Tel
021-67187366 19901745723
Email
info@bwtlab.com
Country
China
ProdList
9652
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
SHANGHAI ZZBIO CO., LTD.
Tel
15102117276 19921389125
Email
tech@zzbioco.com
Country
China
ProdList
12064
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
Tel
025-58851090 17714375163
Email
2881759498@qq.com
Country
China
ProdList
13011
Advantage
58
BePure (Beijing) Biotechnology Co.
Tel
58896805
Email
7993601name@qq.com
Country
CHINA
ProdList
6620
Advantage
58
Shanghai Weiyite Biotechnology Co., Ltd
Tel
15317051735
Email
zhaojing@wytsci.com
Country
China
ProdList
9980
Advantage
58
R&D Systems, Inc
Tel
18003437475
Fax
1-612-656-4400
Email
rdname@qq.com
Country
China
ProdList
6960
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Merck KGaA
Tel
21-20338288
Email
ordercn@merckgroup.com
Country
China
ProdList
6394
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
ShangHai ZskBio CO., LTD
Tel
021-58056897 15399714481
Email
info@zsklab.com
Country
China
ProdList
7190
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8467
Advantage
58
Xingwang Biotechnology Co., Ltd. (Ruijing Testing Company, please do not buy)
Tel
15017521343
Country
CHINA
ProdList
186
Advantage
58
Guangzhou Huiheng Biotechnology Co., Ltd.
Tel
18675945663
Country
CHINA
ProdList
126
Advantage
58
Guangzhou Lucheng Biotechnology Co., Ltd.
Tel
16620452357
Country
CHINA
ProdList
0
Advantage
58
Guangzhou Yansai Biological Products Co., Ltd.
Tel
13710209565
Country
CHINA
ProdList
122
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Guangzhou WeiBo Chemical Co., Ltd.
Tel
--
Fax
--
Email
weibochem@163.com
Country
China
ProdList
6187
Advantage
67

567-02-2, 21-HYDROXYALLOPREGNANOLONERelated Search:

Alphadolone ALLOTETRAHYDRO S 3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate 21-HYDROXYALLOPREGNANOLONE 5-ALPHA-PREGNAN-3-BETA, 17,21-TRIOL-11,20-DIONE ALLOTETRAHYDROCORTICOSTERONE ALLOTETRAHYDROCORTISOL 5-ALPHA-PREGNAN-3-ALPHA, 11-BETA, 17,21-TETROL-20-ONE 3,21-DIACETATE TETRAHYDRODEOXYCORTICOSTERONE 5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE 3-ACETATE 5-ALPHA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 21-ACETATE 5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE DIACETATE 5ALPHA-PREGNANE-3ALPHA,21-DIOL-20-ONE (17,21,21-D3) 5-ALPHA-PREGNAN-3-ALPHA, 11-BETA, 21-TRIOL-20-ONE 3,21-DIACETATE 5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE 21-STEARATE 5-ALPHA-PREGNAN-3-ALPHA, 17,21-TRIOL-11,20-DIONE 3,21-DIACETATE 5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE 21-ACETATE 5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE 3-STEARATE

  • ALLOPREGNANE-3ALPHA,21-DIOL-20-ONE
  • ALLOTETRADEOXYCORTICOSTERONE
  • ALLOTETRAHYDROCORTEXONE
  • ALLOTETRAHYDRODEOXYCORTICOSTERONE
  • ALLOTETRAHYDRODESOXYCORTICOSTERONE
  • ALLOTETRAHYDRO DOC
  • ALLOTETRAHYDRO SUBSTANCE 'Q'
  • ALLO TH DOC
  • 5-ALPHA-PREGNAN-3-ALPHA, 21-DIOL-20-ONE
  • 5ALPHA-PREGNANE-3ALPHA,21-DIOL-20-ONE
  • 3ALPHA,21-DIHYDROXY-5ALPHA-PREGNAN-20-ONE
  • 21-HYDROXYALLOPREGNANOLONE
  • 5A-pregnane-3A,21-diol-20-one
  • 5alpha-Pregnan-3alpha,21-diol-20-one-17,21,21-D3
  • 3α,21-dihydroxy-5α-pregnan-20-one
  • 5α-Pregnane-3α,21-diol-20-one
  • 5α-Pregnan-3α,21-diol-20-one-17,21,21-D3
  • 21-Hydroxyallopregnanolone, 5α-Pregnane-3α,21-diol-20-one, 5α-THDOC, Allopregnane-3α,21-diol-20-one, Allotetrahydrodeoxycorticosterone
  • 3β,5α-Tetrahydrodeoxycorticosterone
  • TDOC
  • 5α-THDOC
  • Allopregnane-3α,21-diol-20-one
  • Allotetrahydrodeoxycorticosterone (Solution)
  • 1-HYDROXYALLOPREGNANOLONE
  • Pregnan-20-one, 3,21-dihydroxy-, (3α,5α)-
  • "3α,21-Dihydroxy-5a-pregnan-20-one"
  • 5alpha-THDOC
  • 3α,21Dihydroxy5αpregnan20one,3α,21 Dihydroxy 5α pregnan 20 one
  • 3α,5α-THDOC
  • 5α-PREGNAN-3α, 21-DIOL-20-ONE
  • 3α,21-Dihydroxy-5α-pregnan-20-one, CAS 567-02-2
  • 3α,21-Dihydroxy-5α-pregnan-20-one
  • 567-02-2
  • C21H31D3O3
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Ligand-Gated Ion Channels
  • Ion Channels
  • GABA and Glycine Receptor Modulators