11-Piperazinyldibenzo[b,e][1,4]diazepine
- Product Name
- 11-Piperazinyldibenzo[b,e][1,4]diazepine
- CAS No.
- 56296-18-5
- Chemical Name
- 11-Piperazinyldibenzo[b,e][1,4]diazepine
- Synonyms
- DREADD agonist 1;DREADD Agonist 21;DREADD agonist 21 ，S0457;DREADD agonist 21, 10 mM in DMSO;DREADD Agonist 21, DREADD agonist;11-Piperazinyldibenzo[b,e][1,4]diazepine;11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine;5H-Dibenzo[b,e][1,4]diazepine, 11-(1-piperazinyl)-;Muscarinic acetylcholine receptor,schizophrenia,mAChR,Inhibitor,muscarinic,disease,inhibit,DREADD agonist21,neurodegenerative,acetylcholine,DREADD agonist 21,DREADD,neuronal,hM3Dq,DREADD agonist-21,activation,receptors
- CBNumber
- CB52650796
- Molecular Formula
- C17H18N4
- Formula Weight
- 278.35
- MOL File
- 56296-18-5.mol
11-Piperazinyldibenzo[b,e][1,4]diazepine Property
- Boiling point:
- 470.1±55.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.8(Max Conc. mM)
Ethanol:29.61(Max Conc. mg/mL);106.39(Max Conc. mM) - form
- A crystalline solid
- pka
- 8.56±0.10(Predicted)
- color
- Yellow
- Water Solubility
- H2O: 2mg/mL, clear
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML2392
- Product name
- DREADD Agonist 21 dihydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $121
- Updated
- 2025/07/31
- Product number
- SML2392
- Product name
- DREADD Agonist 21 dihydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $464.55
- Updated
- 2025/07/31
- Product number
- 18907
- Product name
- DREADD Agonist 21
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 18907
- Product name
- DREADD Agonist 21
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 18907
- Product name
- DREADD Agonist 21
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $210
- Updated
- 2024/03/01
11-Piperazinyldibenzo[b,e][1,4]diazepine Chemical Properties,Usage,Production
Description
DREADD agonist 21 activates hM3Dq (EC50 = 1.7 nM), a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor. It does not agonize the hM3 receptor and displays relatively weaker binding affinities for serotonin 5-HT2A, 5-HT2C, α1A-adrenergic, and histamine H1 receptors (Kis = 66, 170, 280, and 6 nM, respectively).
Uses
DREADD agonist 21 is an agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD). It preferentially binds hM3Dq?DREADDs over endogenous hM3?receptors.
in vivo
DREADD agonist 21 (0.3, 1.0, and 3.0 mg/kg; i.p.) activates neuronal hM3Dq in mice[2].
?
DREADD agonist 21 has excellent bioavailability, pharmacokinetic properties, and brain penetrability. DREADD agonist 21 (0.1, 1, and 10 mg/kg; i.p.) displays 95.1% plasma protein binding and 95% brain protein bounding in mice[2].
IC 50
mAChR3
storage
Room temperature
References
[1] XIN CHEN. The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs[J]. ACS Chemical Neuroscience, 2015, 6 3: 476-484. DOI: 10.1021/cn500325v
11-Piperazinyldibenzo[b,e][1,4]diazepine Preparation Products And Raw materials
Raw materials
Preparation Products
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