ChemicalBook > CAS DataBase List > N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)

Product Name
N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)
CAS No.
1374744-69-0
Chemical Name
N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)
Synonyms
CL121;TG101348(2ClH.H2O);Fedratinib HCl hydrate;Fedratinib Hydrochloride;Fedratinibdihydrochloride;TG-101348 hydrochloride hydrate;Fedratinib HCl hydrate，TG101348;Fedratinib hydrochloride hydrate;SAR 302503 hydrochloride hydrate;TG-101348 dihydrochloride hydrate
CBNumber
CB52651162
Molecular Formula
C27H40Cl2N6O4S
Formula Weight
615.6153
MOL File
1374744-69-0.mol
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N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1) Property

solubility 
DMSO:250.0(Max Conc. mg/mL);409.09(Max Conc. mM)
form 
Solid
color 
White to yellow
InChIKey
QAFZLTVOFJHYDF-UHFFFAOYSA-N
SMILES
C1(S(NC(C)(C)C)(=O)=O)=CC=CC(NC2C(C)=CN=C(NC3=CC=C(OCCN4CCCC4)C=C3)N=2)=C1.[H]O[H].[H]Cl.[H]Cl
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0028556
Product name
Fedratinibhydrochloridehydrate
Purity
99.82%
Packaging
5mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0028556
Product name
Fedratinibhydrochloridehydrate
Purity
99.82%
Packaging
10mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-0028556
Product name
Fedratinibhydrochloridehydrate
Purity
99.82%
Packaging
100mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0028556
Product name
Fedratinibhydrochloridehydrate
Purity
99.82%
Packaging
200mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0028556
Product name
Fedratinibhydrochloridehydrate
Purity
99.82%
Packaging
500mg
Price
$550
Updated
2021/12/16
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N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1) Chemical Properties,Usage,Production

Uses

A potent, highly selective and ATP-competitive JAK2 inhibitor with an IC50 of 3 nM for JAK2 and JAK2V617F.

in vivo

Fedratinib (TG101348; 60-120 mg/kg; oral gavage; twice daily; for 42 days; C57Bl/6 mice) trewatment shows a dose-dependent reduction in polycythemia and a marked dose-dependent reduction in splenomegaly of treated animals[1].

Animal Model:C57Bl/6 mice induced by the JAK2V617F mutation[1]
Dosage:60 mg/kg, 120 mg/kg
Administration:Oral gavage; twice daily; for 42 days
Result:Showed a statistically significant reduction in hematocrit and leukocyte count, a dose-dependent reduction/elimination of extramedullary hematopoiesis.

IC 50

JAK2: 3 nM (IC50); JAK2(V617F): 3 nM (IC50); Flt3: 15 nM (IC50); Ret: 48 nM (IC50)

N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1) Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1) Suppliers

China 49 United States 3 Global 52
Shanghai Thunder Biological Technology Co., Ltd.
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18621609968
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1162686636@qq.com
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China
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Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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Jinan Trio PharmaTech Co., Ltd.
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0531-88811783
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+86 (531) 55696010 QQ 1762738062
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sales@trio-pharmatech.com
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ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185
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sales-cpd@caerulumpharma.com
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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028-81705658
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3003855609@qq.com
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Finetech Industry Limited
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027-87465837 19945049750
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027-8777-2287
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sales@finetechnology-ind.com
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LETOPHARM LIMITED
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+86-21-5821 5861
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+86-21-5106 2861
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sales@letopharm.com
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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71826
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Raw material medicin reagent co.,Ltd
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sales@njromanme.com
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1374744-69-0, N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)Related Search:


  • CL121
  • N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate (1:2:1)
  • TG101348(2ClH.H2O)
  • TG-101348 dihydrochloride hydrate
  • N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide hydrochloride hydrate
  • Fedratinib hydrochloride hydrate
  • N-(tert-Butyl)-3-((5-methyl-2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide dihydrochloride hydrate
  • Fedratinib (TG101348) dihydrochloride hydrate
  • SAR 302503 hydrochloride hydrate
  • TG-101348 hydrochloride hydrate
  • Fedratinib Hydrochloride
  • Fedratinib HCl hydrate，TG101348
  • Fedratinib dihydrochloride monohydrate
  • Fedratinibdihydrochloride
  • STAT5,JAK2V617F,myeloproliferative,TG-101348 hydrochloride,Janus kinase,phosphorylation,anti-proliferation,FLT3,Apoptosis,inhibit,RET,orally,JAK,SAR 302503 hydrochloride,Fedratinib hydrochloride hydrate,anti-cancer,JAK2,Inhibitor,Fedratinib hydrochloride
  • Fedratinib HCl hydrate
  • Fedratinib hydrochloride hydrate, 10 mM in DMSO
  • 1374744-69-0
  • C27H36N6O3S2HClH2O