ChemicalBook > CAS DataBase List > (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester

Product Name
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
CAS No.
401564-36-1
Chemical Name
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
Synonyms
Teneint-G;Tenaligliptin;Teneligptin interMediate B;Teneligliptin Intermediate;Teneligptin interMediate-1;Teneliglitpin intermediates;Teneligliptin Intermediate-1;Ethyl(2)-chloro[(4-methoxyphenyl)hydrazono]ethanoate;(S)-1-Boc-5-(thiazolidine-3-carbonyl)pyrrolidin-3-one;(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecar
CBNumber
CB52651238
Molecular Formula
C13H20N2O4S
Formula Weight
300.37
MOL File
401564-36-1.mol
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(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Property

Boiling point:
492℃
Density 
1.305
Flash point:
251℃
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
-1.22±0.20(Predicted)
form 
Solid
color 
Pale Yellow to Light Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
O870490
Product name
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylicAcid1,1-DimethylethylEster
Packaging
500mg
Price
$245
Updated
2021/12/16
Ark Pharm
Product number
P000099749
Product name
(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
Purity
95+%
Packaging
500g
Price
$563
Updated
2021/12/16
Ark Pharm
Product number
P000099749
Product name
(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
Purity
95+%
Packaging
1g
Price
$7
Updated
2021/12/16
Ark Pharm
Product number
P000099749
Product name
(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
Purity
95+%
Packaging
5g
Price
$20
Updated
2021/12/16
Ark Pharm
Product number
P000099749
Product name
(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
Purity
95+%
Packaging
10g
Price
$34
Updated
2021/12/16
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(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Uses

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.

Synthesis

To (2S)-1-tertbutyloxycarbonyl-4-oxa-tetramethyleneimine-2-carboxylic acid (60.0kg), thiazolidine (30.3kg) and the solution of N-diisopropylethylamine (118kg) in ethyl acetate (595kg), adds the solution of 28w% propyl phosphonous acid anhydride (cyclic trimer) in ethyl acetate (446kg) at 2 ℃-7 ℃, and reaction mixture is stirred 2 hours at 2 ℃-4 ℃.To this reaction mixture, add 15w% aqueous citric acid solution (600kg) for distributing, and ethyl acetate for water layer (271kg) is extracted.
The ethyl acetate layer obtaining is mixed, and use successively 10w% ammonium dibasic phosphate aqueous solution (600kg) and water (300kg) washing. Ethyl acetate layer is concentrated into residual quantity 300L, normal heptane (739kg), 23 ℃ of-25 ℃ of interpolations, and is stirred this mixture 1 hour at 23 ℃-25 ℃, and stir 2 hours at 1 ℃-5 ℃.
The crystal of precipitation is collected by filtration, is used normal heptane (164kg) washing drying under reduced pressure to produce (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester (67.8kg, yield 86%).

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Suppliers

China 214 Germany 1 India 15 United States 5 Global 235
Inner Mongolia Slanke Pharm-Tech Co., Ltd
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China
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View Lastest Price from (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester manufacturers

Qiuxian Baitai New Material Co., LTD
Product
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
Price
US $15.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
100tons
Release date
2021-12-20
Longyan Tianhua Biological Technology Co., Ltd
Product
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
Price
US $9.00/KG
Min. Order
25KG
Purity
99.99
Supply Ability
999
Release date
2020-10-24
Chemwill Asia Co.,Ltd.
Product
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
High quality Factory
Release date
2019-04-05

401564-36-1, (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl esterRelated Search:

TRANS-5-(4-CHLOROPHENYL)-4-METHYL-2-THIAZOLIDONE 2-Phenoxyethanol thiazoline Hydroxyethyl Cellulose 1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine

  • (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
  • 1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbonyl)-, 1,1-diMethylethyl ester, (2S)-
  • (2S)-4-oxo-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate
  • (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
  • (2S)-tert-butyl 4-hydroxy-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
  • Teneligptin interMediate B
  • tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
  • (2S)-4-Oxo-2-(thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acid t-butyl ester
  • (2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidincarbaxilic acid tert-butyl ester
  • (2S)-4-Oxo-2-(thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acidtert-butylester
  • Teneligliptin Intermediate-1
  • Teneligliptin Intermediate
  • (S)-tert-butyl 3-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
  • (S)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrolidine-1-carboxylate
  • Teneint-G
  • tert-butyl(2s)-4-oxo-2-(1,3-thiazolidin-3-yl carbonyl) pyrrolidine-1-carboxylate
  • tert-butyl (2S)-4-oxo-2-(1,3-thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
  • (S)-1-Boc-5-(thiazolidine-3-carbonyl)pyrrolidin-3-one
  • (2S) -4-oxo-2- (3-thiazolidinylcarbonyl) -1-Pyrrolidinecarboxylic acid tert-butyl ester / triliptin intermediate
  • 3-((S)-1-tert-butoxycarbonyl-4-oxo-2-pyrrolidinylcarbonyl)-1,3-thiazolidine
  • Teneligptin interMediate-1
  • Tenaligliptin
  • 4-oxo-2-(3-thiazolidinylcarbonyl)-,1,1-dimethylethylester
  • 1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbon...
  • tert-butyl (S)-4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
  • Ethyl(2)-chloro[(4-methoxyphenyl)hydrazono]ethanoate
  • (S)-tert-Butyl4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylat
  • Teneliglitpin intermediates
  • Tert-butyl (2S) -4-oxo-2-(1,3-Thiazoldine-3yl carboxyl) pyrrolidine-1-carboxylate
  • (2S) -4-oxo-2- (3-thiazolylcarbonyl) -1-pyrrolidine carboxylate tert butyl ester
  • (2S)-4-oxo-2-(1,3-thiazolidin- 3-yIcarbonyI)pyrroIidine carboxylic acid tert butyl ester
  • Tenteligliptin impurity 1 (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester
  • (2S)-4-Oxo-2-(thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acid t-butyl ester ( Boc-Pyrrolidinone)
  • (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecar
  • 401564-36-1