(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
- Product Name
- (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
- CAS No.
- 401564-36-1
- Chemical Name
- (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
- Synonyms
- Teneint-G;Tenaligliptin;Teneligptin interMediate B;Teneligliptin Intermediate;Teneligptin interMediate-1;Teneliglitpin intermediates;Teneligliptin Intermediate-1;Ethyl(2)-chloro[(4-methoxyphenyl)hydrazono]ethanoate;(S)-1-Boc-5-(thiazolidine-3-carbonyl)pyrrolidin-3-one;(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecar
- CBNumber
- CB52651238
- Molecular Formula
- C13H20N2O4S
- Formula Weight
- 300.37
- MOL File
- 401564-36-1.mol
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Property
- Boiling point:
- 492℃
- Density
- 1.305
- Flash point:
- 251℃
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- -1.22±0.20(Predicted)
- form
- Solid
- color
- Pale Yellow to Light Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O870490
- Product name
- (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylicAcid1,1-DimethylethylEster
- Packaging
- 500mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- P000099749
- Product name
- (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 500g
- Price
- $563
- Updated
- 2021/12/16
- Product number
- P000099749
- Product name
- (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $7
- Updated
- 2021/12/16
- Product number
- P000099749
- Product name
- (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- P000099749
- Product name
- (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $34
- Updated
- 2021/12/16
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Uses
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.
Synthesis
To (2S)-1-tertbutyloxycarbonyl-4-oxa-tetramethyleneimine-2-carboxylic
acid (60.0kg), thiazolidine (30.3kg) and the solution
of N-diisopropylethylamine (118kg) in ethyl acetate (595kg), adds the
solution of 28w% propyl phosphonous acid anhydride (cyclic trimer)
in ethyl acetate (446kg) at 2 ℃-7 ℃, and reaction mixture is stirred 2
hours at 2 ℃-4 ℃.To this reaction mixture, add 15w% aqueous citric acid
solution (600kg) for distributing, and ethyl acetate for water layer
(271kg) is extracted.
The ethyl acetate layer obtaining is mixed, and use
successively 10w% ammonium dibasic phosphate aqueous solution (600kg)
and water (300kg) washing. Ethyl acetate layer is concentrated into
residual quantity 300L, normal heptane (739kg), 23 ℃ of-25 ℃ of
interpolations, and is stirred this mixture 1 hour at 23 ℃-25 ℃, and
stir 2 hours at 1 ℃-5 ℃.
The crystal of precipitation is collected by
filtration, is used normal heptane (164kg) washing drying under reduced
pressure to produce (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester (67.8kg, yield 86%).
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Suppliers
- Tel
- +918790379245
- banny.janga@btcpharm.com
- Country
- India
- ProdList
- 1269
- Advantage
- 58
View Lastest Price from (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester manufacturers
- Product
- (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
- Price
- US $15.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 100tons
- Release date
- 2021-12-20
- Product
- (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
- Price
- US $9.00/KG
- Min. Order
- 25KG
- Purity
- 99.99
- Supply Ability
- 999
- Release date
- 2020-10-24
- Product
- (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- High quality Factory
- Release date
- 2019-04-05