(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester

Product Name: (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
CAS No.: 401564-36-1
Chemical Name: (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
Synonyms: Teneint-G;Tenaligliptin;Teneligptin interMediate B;Teneligliptin Intermediate;Teneligptin interMediate-1;Teneliglitpin intermediates;Teneligliptin Intermediate-1;Ethyl(2)-chloro[(4-methoxyphenyl)hydrazono]ethanoate;(S)-1-Boc-5-(thiazolidine-3-carbonyl)pyrrolidin-3-one;(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecar
CBNumber: CB52651238
Molecular Formula: C13H20N2O4S
Formula Weight: 300.37
MOL File: 401564-36-1.mol

More

Less

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Property

Boiling point:: 492℃
Density: 1.305
Flash point:: 251℃
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: -1.22±0.20(Predicted)
form: Solid
color: Pale Yellow to Light Yellow

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: O870490
Product name: (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylicAcid1,1-DimethylethylEster
Packaging: 500mg
Price: $245
Updated: 2021/12/16

Ark Pharm

Product number: P000099749
Product name: (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 500g
Price: $563
Updated: 2021/12/16

Ark Pharm

Product number: P000099749
Product name: (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 1g
Price: $7
Updated: 2021/12/16

Ark Pharm

Product number: P000099749
Product name: (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 5g
Price: $20
Updated: 2021/12/16

Ark Pharm

Product number: P000099749
Product name: (S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 10g
Price: $34
Updated: 2021/12/16

More

Less

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Uses

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate used to prepare dipeptidyl peptidase IV (DPP-IV) inhibitors.

Synthesis

To (2S)-1-tertbutyloxycarbonyl-4-oxa-tetramethyleneimine-2-carboxylic acid (60.0kg), thiazolidine (30.3kg) and the solution of N-diisopropylethylamine (118kg) in ethyl acetate (595kg), adds the solution of 28w% propyl phosphonous acid anhydride (cyclic trimer) in ethyl acetate (446kg) at 2 ℃-7 ℃, and reaction mixture is stirred 2 hours at 2 ℃-4 ℃.To this reaction mixture, add 15w% aqueous citric acid solution (600kg) for distributing, and ethyl acetate for water layer (271kg) is extracted.
The ethyl acetate layer obtaining is mixed, and use successively 10w% ammonium dibasic phosphate aqueous solution (600kg) and water (300kg) washing. Ethyl acetate layer is concentrated into residual quantity 300L, normal heptane (739kg), 23 ℃ of-25 ℃ of interpolations, and is stirred this mixture 1 hour at 23 ℃-25 ℃, and stir 2 hours at 1 ℃-5 ℃.
The crystal of precipitation is collected by filtration, is used normal heptane (164kg) washing drying under reduced pressure to produce (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester (67.8kg, yield 86%).

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester Suppliers

China 223 Germany 1 India 15 United States 5 Global 244

Inner Mongolia Slanke Pharm-Tech Co., Ltd

Tel: 0479-2224266; 15047962002
Email: 1304140798@qq.com
Country: China
ProdList: 73
Advantage: 58

Shanghai Sagachem Co., Ltd.

Tel: 13816115801
Email: raochenaone@126.com
Country: China
ProdList: 198
Advantage: 58

Nanjing Yunzhi Xinhe Biotechnology Co., Ltd

Tel: 19852363252; 19852363252
Email: 2634809846@qq.com
Country: China
ProdList: 53
Advantage: 58

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: sales@zhiwe.net
Country: China
ProdList: 608
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9499
Advantage: 66

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3203
Advantage: 55

Chengdu Yuyang High-Tech Developing Co., Ltd

Tel: +86-28-61777709
Fax: +86-28-61777709
Email: yygk@yygk.com
Country: China
ProdList: 69
Advantage: 58

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 021-34666753 13311639313
Fax: +86-21-34979012
Email: info@shyrchem.com
Country: China
ProdList: 571
Advantage: 55

Cangzhou Senary Chemical Science-tech Co., Ltd

Tel: +86-317-3563899
Fax: +86-317-3563199
Email: trade@senary.com
Country: China
ProdList: 98
Advantage: 56

More

Less

View Lastest Price from (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester manufacturers

Qiuxian Baitai New Material Co., LTD

Product: (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
Price: US $15.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 100tons
Release date: 2021-12-20

Longyan Tianhua Biological Technology Co., Ltd

Product: (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
Price: US $9.00/KG
Min. Order: 25KG
Purity: 99.99
Supply Ability: 999
Release date: 2020-10-24

Chemwill Asia Co.,Ltd.

Product: (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester 401564-36-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: High quality Factory
Release date: 2019-04-05

401564-36-1, (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl esterRelated Search:

TRANS-5-(4-CHLOROPHENYL)-4-METHYL-2-THIAZOLIDONE 2-Phenoxyethanol thiazoline Hydroxyethyl Cellulose 1-(3-Methyl-1-phenyl-5-pyrazolyl)piperazine

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester

1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbonyl)-, 1,1-diMethylethyl ester, (2S)-

(2S)-4-oxo-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate

(S)-tert-Butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

(2S)-tert-butyl 4-hydroxy-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

Teneligptin interMediate B

tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

(2S)-4-Oxo-2-(thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acid t-butyl ester

(2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidincarbaxilic acid tert-butyl ester

(2S)-4-Oxo-2-(thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acidtert-butylester

Teneligliptin Intermediate-1

Teneligliptin Intermediate

(S)-tert-butyl 3-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

(S)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrolidine-1-carboxylate

Teneint-G

tert-butyl(2s)-4-oxo-2-(1,3-thiazolidin-3-yl carbonyl) pyrrolidine-1-carboxylate

tert-butyl (2S)-4-oxo-2-(1,3-thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

(S)-1-Boc-5-(thiazolidine-3-carbonyl)pyrrolidin-3-one

(2S) -4-oxo-2- (3-thiazolidinylcarbonyl) -1-Pyrrolidinecarboxylic acid tert-butyl ester / triliptin intermediate

3-((S)-1-tert-butoxycarbonyl-4-oxo-2-pyrrolidinylcarbonyl)-1,3-thiazolidine

Teneligptin interMediate-1

Tenaligliptin

4-oxo-2-(3-thiazolidinylcarbonyl)-,1,1-dimethylethylester

1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbon...

tert-butyl (S)-4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate

Ethyl(2)-chloro[(4-methoxyphenyl)hydrazono]ethanoate

(S)-tert-Butyl4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylat

Teneliglitpin intermediates

Tert-butyl (2S) -4-oxo-2-(1,3-Thiazoldine-3yl carboxyl) pyrrolidine-1-carboxylate

(2S) -4-oxo-2- (3-thiazolylcarbonyl) -1-pyrrolidine carboxylate tert butyl ester

(2S)-4-oxo-2-(1,3-thiazolidin- 3-yIcarbonyI)pyrroIidine carboxylic acid tert butyl ester

Tenteligliptin impurity 1 (2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester

(2S)-4-Oxo-2-(thiazolidine-3-carbonyl)-pyrrolidine-1-carboxylic acid t-butyl ester ( Boc-Pyrrolidinone)

(2S)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecar

401564-36-1