ChemicalBook > CAS DataBase List > J 147

J 147

Product Name: J 147
CAS No.: 1146963-51-0
Chemical Name: J 147
Synonyms: J 147;CS-1446;J147-API;J147/J-147;J-147?, >98%;Nootropic J147;J-147, 10 mM in DMSO;J 147(Nootropic Powder);CAS 1146963-51-0 J 147;J147 MOQ is 10g/bag j147
CBNumber: CB52652639
Molecular Formula: C18H17F3N2O2
Formula Weight: 350.33
MOL File: 1146963-51-0.mol

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J 147 Property

Boiling point:: 412.8±55.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO:68.0(Max Conc. mg/mL);194.1(Max Conc. mM)
form: Powder
pka: 0.80±0.50(Predicted)
color: Off-white to pink
InChI: InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3
InChIKey: HYMZAYGFKNNHDN-UHFFFAOYSA-N
SMILES: C(N(C1=CC=C(C)C=C1C)N=CC1=CC=CC(OC)=C1)(=O)C(F)(F)F

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 5081
Product name: J147
Purity: ≥99%(HPLC)
Packaging: 10
Price: $182
Updated: 2021/12/16

Tocris

Product number: 5081
Product name: J147
Purity: ≥99%(HPLC)
Packaging: 50
Price: $745
Updated: 2021/12/16

TRC

Product number: J210300
Product name: J147
Packaging: 10mg
Price: $165
Updated: 2021/12/16

ApexBio Technology

Product number: B5804
Product name: J147
Packaging: 10mg
Price: $171
Updated: 2021/12/16

ChemScene

Product number: CS-3688
Product name: J-147
Purity: 99.87%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

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J 147 Chemical Properties,Usage,Production

Uses

J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer''s disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer''s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.

Definition

ChEBI: J147 is an anilide.

benefits

J 147 improves heart health by lowering blood pressure, boosts metabolism, supports digestive and immune system function, improves cognitive function, has no side effects, and increases physical strength with long-term use. Once there is significant weight loss after taking it, this supplement helps people maintain their weight by reducing cravings and increasing energy levels. Since it helps suppress the hunger hormone that causes overeating, people who use J147 capsules for a long time are more likely to maintain their weight

Biological Activity

J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

Synthesis

391646-35-8

407-25-0

1146963-51-0

Trifluoroacetic anhydride (0.33 mL, 2.36 mmol) was added slowly and dropwise to a stirred solution of 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide (500 mg, 1.97 mmol) and triethylamine (0.33 mL, 2.36 mmol) in dichloromethane (5 mL) at 0 °C and under nitrogen protection. The reaction mixture was stirred continuously at 0°C for 1.5 hours. Upon completion of the reaction, the mixture was concentrated and the residue was purified by column chromatography using acetone/hexane (1:10) as eluent to afford the target product 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylidene]hydrazide (571 mg, 83% yield) as a light yellow oil.1H NMR (CDCl3) data were as follows: δ7.26-7.23 (m, 4H), 7.19 (d, J = 8.0 Hz, 1H), 7.12 (d, J = 7.5 Hz, 1H), 7.03 (d, J = 8.0 Hz, 1H), 6.92 (dd, J = 8.5,2.0 Hz, 1H), 3.79 (s, 3H), 2.39 (s, 3H), 2.08 (s 3H). High-resolution mass spectrometry (ESI-TOF, m/z) analysis resulted in a calculated value of 351.1320 for C18H18N2O2F3 ([M + H]+); the measured value was 351.1311.

storage

Store at +4°C

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 2, p. 524 - 527

J 147 Preparation Products And Raw materials

Raw materials

Preparation Products

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J 147 Suppliers

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View Lastest Price from J 147 manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: J 147 1146963-51-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-12-01

Jinan Jianfeng Chemical Co., Ltd

Product: J 147 1146963-51-0
Price: US $0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20ton
Release date: 2025-08-26

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: J-147 1146963-51-0
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-21

1146963-51-0, J 147Related Search:

2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Deionized water

J147/J-147

2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide

J 147

N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE

J 147 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

Nootropic J147

CS-1446

J-147?, >98%

J147-API

Acetic acid, 2,2,2-trifluoro-, 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N''-[(1E)-(3-methoxyphenyl)methylidene]acetohydrazide

(E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide

J 147(Nootropic Powder)

N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-(3-methoxybenzylidene)acetohydrazide

CAS 1146963-51-0 J 147

oxidase,dopamine,brain,disease,MAO B,Inhibitor,SLC6A3,DAT,J 147,blood,neuroprotective,inhibit,Monoamine Oxidase,MAO,transporte,monoamine,Dopamine Transporter,Alzheimer,BBB,barrier,J-147

n-(2,4-dimethylphenyl)-n-(3-methoxybenzylidene)acetohydrazide

N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide

N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(1E)-(3-methoxyphenyl)methylidene]acetohydrazide

J-147, 10 mM in DMSO

J147 MOQ is 10g/bag j147

1146963-51-0

Inhibitors

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

1146963-51-0

J-147