2-(2-Methyl-6-nitrophenyl)acetic acid
- Product Name
- 2-(2-Methyl-6-nitrophenyl)acetic acid
- CAS No.
- 23876-18-8
- Chemical Name
- 2-(2-Methyl-6-nitrophenyl)acetic acid
- Synonyms
- 2-Methyl-6-nitrobenzeneacetic acid;(6-Methyl-2-nitrophenyl)acetic acid;2-(2-Methyl-6-nitrophenyl)acetic acid;Benzeneacetic acid, 2-methyl-6-nitro-;2-(2-Methyl-6-nitrophenyl)aceticacid,95%;Methyl 3-[4-(aminomethyl)p2-(2-Methyl-6-nitrophenyl)acetic acidhenyl]propionate
- CBNumber
- CB52657386
- Molecular Formula
- C9H9NO4
- Formula Weight
- 195.17
- MOL File
- 23876-18-8.mol
2-(2-Methyl-6-nitrophenyl)acetic acid Property
- form
- Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CM251597
- Product name
- 2-(2-Methyl-6-nitrophenyl)aceticacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $255
- Updated
- 2021/12/16
- Product number
- 61-11012
- Product name
- 2-(2-Methyl-6-nitrophenyl)aceticacid
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $468
- Updated
- 2021/12/16
- Product number
- AR006UU0
- Product name
- 2-(2-Methyl-6-nitrophenyl)aceticacid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $28
- Updated
- 2021/12/16
2-(2-Methyl-6-nitrophenyl)acetic acid Chemical Properties,Usage,Production
Synthesis
83-41-0
95-92-1
23876-18-8
1. Diethyl oxalate (3.9 g, 27 mmol) was dissolved in 30 mL of diethyl ether and added slowly and dropwise to a 6 mL ether suspension of potassium ethanolate (2.3 g, 27 mmol) under stirring. 2. After refluxing had subsided, the reaction mixture was cooled in an ice bath, followed by the slow addition of 3-nitro-o xylene (2.8 g, 18 mmol) dissolved in 3 mL of diethyl ether while maintaining vigorous stirring. 3. The reaction mixture was refluxed for 15 minutes and a thick precipitate was observed to form. 4. The reaction mixture was heated under vacuum to remove most of the ether, followed by the slow addition of 18 mL of 10% sodium hydroxide solution with stirring. 5. hydrogen peroxide (4 mL, 30%) was added slowly and dropwise, during which the reaction was vigorous and accompanied by gas release. 6. Continue stirring the reaction mixture for 1.5 hours. 7. The solid product was collected by vacuum filtration, washed with water and discarded. 8. 8. The filtrate and washings were combined and acidified with 12 N hydrochloric acid to pH 2. 9. 9. The precipitated solid was again collected by vacuum filtration, washed with water and dried under vacuum. 10. The crude product was ground with dichloromethane and further dried under vacuum to give 1.8 g of 2-(2-methyl-6-nitrophenyl)acetic acid in 52% yield.
References
[1] Patent: US2004/186160, 2004, A1. Location in patent: Page/Page column 22
[2] Patent: US6878733, 2005, B1. Location in patent: Page/Page column 168; 217
[3] Patent: US6350754, 2002, B2. Location in patent: Page column 19-20
[4] Journal of the Chemical Society. Perkin transactions 1, 1969, vol. 14, p. 1935 - 1939
2-(2-Methyl-6-nitrophenyl)acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(2-Methyl-6-nitrophenyl)acetic acid manufacturers
- Product
- Methyl 3-[4-(aminomethyl)p2-(2-Methyl-6-nitrophenyl)acetic acidhenyl]propionate 23876-18-8
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12