2-Methyl-6-quinolinecarboxylic acid

Product Name: 2-Methyl-6-quinolinecarboxylic acid
CAS No.: 635-80-3
Chemical Name: 2-Methyl-6-quinolinecarboxylic acid
Synonyms: Quinaldine-6-carboxylic acid;2-Methyl-6-QuinolinecarboxylicAci;2-METHYLQUINOLINE-6-CARBOXYLIC ACID;2-METHYL-6-QUINOLINECARBOXYLIC ACID;6-Quinolinecarboxylicacid, 2-Methyl-;2-Methylquinoline-6-carboxylicacid,97%;2-Methylquinoline-6-carboxylic acid 99%;2-Methylquinoline-6-carboxylic Acid >2-Methyl-6-quinolinecarboxylic acid ,97%;2-Methyl-6-quinolinecarboxylic acid ISO 9001：2015 REACH
CBNumber: CB2238092
Molecular Formula: C11H9NO2
Formula Weight: 187.19
MOL File: 635-80-3.mol

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2-Methyl-6-quinolinecarboxylic acid Property

Melting point:: 250 °C
Boiling point:: 347.6±27.0 °C(Predicted)
Density: 1.285±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.13±0.30(Predicted)
form: Solid
color: White to Light yellow to Light orange
InChI: InChI=1S/C11H9NO2/c1-7-2-3-8-6-9(11(13)14)4-5-10(8)12-7/h2-6H,1H3,(H,13,14)
InChIKey: IZONZQFTYGVOOO-UHFFFAOYSA-N
SMILES: N1C2C(=CC(C(O)=O)=CC=2)C=CC=1C
CAS DataBase Reference: 635-80-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-26-36/37/39
Hazard Note: Irritant
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2625
Product name: 2-Methylquinoline-6-carboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: M2625
Product name: 2-Methylquinoline-6-carboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $91
Updated: 2025/07/31

TRC

Product number: M329343
Product name: 2-Methylquinoline-6-carboxylic Acid
Packaging: 500mg
Price: $60
Updated: 2021/12/16

TRC

Product number: M329343
Product name: 2-Methylquinoline-6-carboxylic Acid
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J98357
Product name: 2-Methyl-6-quinolinecarboxylicacid
Packaging: 25g
Price: $80
Updated: 2021/12/16

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2-Methyl-6-quinolinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

2-Methylquinoline-6-carboxylic Acid is a preparation of arylpyrazolopyridine derivative as monoacylglycerol lipase modulators.

Synthesis

150-13-0

123-73-9

635-80-3

General procedure for the synthesis of 2-methyl-6-quinoline carboxylic acid from p-aminobenzoic acid and trans-2-butenal: Intermediate 13: Synthesis of (2-methylquinolin-6-yl)methylamine: Step 1: Preparation of 2-methylquinoline-6-carboxylic acid: 6N hydrochloric acid (73 ml) was added to 4-aminobenzoic acid (5 g, 36.45 mmol) and heated to reflux for 2 hours. Subsequently, crotonaldehyde (3.06 g, 43.75 mmol) was added slowly and dropwise over 45 min. After 12 hours of reaction, the reaction mixture was cooled to 0 °C and the pH was adjusted to 3-5 with aqueous ammonia solution. the aqueous phase was extracted with dichloromethane, the organic phases were combined and acidified with 2N hydrochloric acid, the precipitate was collected by filtration and dried under vacuum to afford 2-methyl-6-quinolinecarboxylic acid as a brown solid (3.0 g, 44% yield).

References

[1] Patent: WO2013/144737, 2013, A2. Location in patent: Paragraph 252
[2] Patent: US2015/57309, 2015, A1. Location in patent: Paragraph 0524
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 21, p. 4647 - 4654
[4] Chemistry - A European Journal, 2018, vol. 24, # 61, p. 16368 - 16378
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 22, p. 6138 - 6141

2-Methyl-6-quinolinecarboxylic acid Preparation Products And Raw materials

Raw materials

Paraldehyde Crotonaldehyde (trans predominantly) 4-Aminobenzoic acid Sodium iodide Hydrochloric acid Dichloromethane PETROLEUM ETHER

Preparation Products

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2-Methyl-6-quinolinecarboxylic acid Suppliers

Americas 1 Belgium 1 China 133 Europe 2 Germany 3 India 5 Japan 1 United Kingdom 7 United States 19 Global 172

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View Lastest Price from 2-Methyl-6-quinolinecarboxylic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Methyl-6-quinolinecarboxylic acid 635-80-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-25

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2-Methyl-6-quinolinecarboxylic acid 635-80-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-13

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Methylquinoline-6-carboxylic acid 635-80-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

635-80-3, 2-Methyl-6-quinolinecarboxylic acidRelated Search:

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2-Methylquinoline-6-carboxylic acid 99%

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2-Methyl-6-QuinolinecarboxylicAci

2-Methyl-6-quinolinecarboxylic acid ISO 9001：2015 REACH

635-80-3

C11H9O2N

Carboxylic Acids

Quinolines, Isoquinolines & Quinoxalines

quinoline

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Carboxylic Acids

Quinolines, Isoquinolines & Quinoxalines

Heterocyclic Compounds

Quinolines