(+/-)-THIOPENTAL Property

Melting point:

158-160°C

Density 

1.1789 (rough estimate)

refractive index 

1.5440 (estimate)

Flash point:

11℃

storage temp. 

2-8°C

solubility 

ethanol: complete50mg/mL

pka

7.11±0.40(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

50mg/L(25 ºC)

CAS DataBase Reference

76-75-5(CAS DataBase Reference)

EPA Substance Registry System

4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (76-75-5)

Safety

Hazard Codes 

Xn,T,F

Risk Statements 

22-39/23/24/25-23/24/25-11

Safety Statements 

36/37/39-45-36/37-16-7

RIDADR 

UN 1230 3/PG 2

WGK Germany 

3

RTECS 

CQ6300000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2933595960

Hazardous Substances Data

76-75-5(Hazardous Substances Data)

Toxicity

cyt-hmn:leu 1500 mg/L TGANAK18(1),13,84

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

(+/-)-THIOPENTAL Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Originator

Pentothal,Abbott

Uses

A thio-derivative of Barbituric acid. Controlled substance (depressant). Anesthetic

Definition

ChEBI: Thiopental is a barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups. It has a role as an anticonvulsant, a sedative, an environmental contaminant, a xenobiotic, a drug allergen and an intravenous anaesthetic. It is functionally related to a 2-thiobarbituric acid. It is a conjugate acid of a thiopental(1-).

Manufacturing Process

130 g of ethyl (1-methylbutyl) malonic ester is added to a concentrated solution of sodium ethylate prepared from 34 g of sodium in absolute alcohol; with stirring, 60 g of finely divided thiourea is added, and, the mixture refluxed for 10 hours. Most or all of the solvent is evaporated and the residual mass is dissolved in cold water. The barbituric acid derivative so formed is precipitated by the addition of dilute hydrochloric acid. It may be 1 purified by solution in dilute ammonium hydroxide solution and precipitated by carbon dioxide, followed by recrystallization from 95% alcohol. The ethyl (1- methylbutyl)thiobarbituric acid so obtained is a white crystalline solid, melting at 158-159°C and readily forming salts with alkalies.

brand name

Thiopental is BAN.

Therapeutic Function

Narcotic analgesic, Anesthetic

Safety Profile

Poison by intraperitoneal, intravenous, and rectal routes. Moderately toxic by ingestion. An experimental teratogen. Human mutation data reported. A short-acting intravenous anesthetic. When heated to decomposition it emits very toxic fumes of NOx and SOx