Leukadherin 1
- Product Name
- Leukadherin 1
- CAS No.
- 344897-95-6
- Chemical Name
- Leukadherin 1
- Synonyms
- CS-2237;eukadherin-1;Leukadherin-1;Leukadherin 1;Leukadhedrin 1;LA1(Leukadherin-1);LEUKADHERIN 1;LEUKADHERIN1;4-(5-((3-Benzyl-4-oxo-2-thioxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid;4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid;Benzoic acid, 4-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
- CBNumber
- CB52667990
- Molecular Formula
- C22H15NO4S2
- Formula Weight
- 421.49
- MOL File
- 344897-95-6.mol
Leukadherin 1 Property
- Boiling point:
- 634.7±65.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble3mg/mL, clear (warmed)
- pka
- 4.11±0.10(Predicted)
- form
- powder
- color
- , yellow to orange to brown
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML0886
- Product name
- Leukadherin-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- SML0886
- Product name
- Leukadherin-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $419
- Updated
- 2024/03/01
- Product number
- 14855
- Product name
- Leukadherin 1
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 14855
- Product name
- Leukadherin 1
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 14855
- Product name
- Leukadherin 1
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $234
- Updated
- 2024/03/01
Leukadherin 1 Chemical Properties,Usage,Production
Uses
Leukadherin 1 is a small molecule agonist that enhances CD11b/CD18-dependent cell adhesion to its ligand ICAM-1 (1). Complement receptor 3 (CR3, CD11b/CD18) is a cell surface receptor expressed on myeloid and natural killer cells (2).
Biological Activity
leukadherin 1 is an activator of cd11b/cd18 [1].cd11b/cd18 is a cell surface adhesion receptor that mediates immune functions and leukocyte migration and is expressed primarily in the cells of the innate immune system.leukadherin 1 is a cd11b/cd18 activator. leukadherin 1 increased cd11b/cd18-dependent cell adhesion to fibrinogen with ec50 value of 4 μm [1]. leukadherin 1 increased cd11b/cd18-dependent cell adhesion to its ligand icam-1. in k562 cells, leukadherin 1 increased the binding of cd11b/cd18 to icam-1 through the formation of long membrane tethers [2].in the acute peritonitis mice model, leukadherin 1 significantly reduced neutrophil accumulation by 40% [1]. in a mhc mismatched orthotopic kidney transplantation mouse model, leukadherin 1 reduced interstitial leukocyte infiltration, glomerular damage, neointimal hyperplasia and prolonged survival from 48.5% (csa only) to 100% (csa and la1) [3]. in newborn rats exposed to hyperoxia (85% o2), leukadherin 1 reduced both macrophage and neutrophil infiltration in the lungs [4].
References
[1]. maiguel d, faridi mh, wei c, et al. small molecule-mediated activation of the integrin cd11b/cd18 reduces inflammatory disease. sci signal, 2011, 4(189): ra57.
[2]. celik e1, faridi mh, kumar v, et al. agonist leukadherin-1 increases cd11b/cd18-dependent adhesion via membrane tethers. biophys j, 2013, 105(11): 2517-2527.
[3]. khan sq, guo l, cimbaluk dj, et al. a small molecule b2 integrin agonist improves chronic kidney allograft survival by reducing leukocyte recruitment and accompanying vasculopathy. front med (lausanne), 2014, 1: 45.
[4]. jagarapu j, kelchtermans j, rong m, et al. leukadherin-1 attenuates hyperoxia-induced lung injury in neonatal rats. am j respir cell mol biol, 2015.
Leukadherin 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Leukadherin 1 manufacturers
- Product
- Leukadherin 1 344897-95-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23