ChemicalBook > CAS DataBase List > BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-

BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-

Product Name
BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-
CAS No.
950736-05-7
Chemical Name
BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-
Synonyms
CS-1184;MDK36057;RAF-IN-10n;B-Raf IN 1;B-Raf inhibit 1;B-Raf IN 1, >=98%;B-Raf IN 1, 10 mM in DMSO;Raf kinases,B-Raf IN 1,BRaf IN 1,Inhibitor,B Raf IN 1,Raf,inhibit;N-(3-(3-(4-((diMethylaMino)Methyl)phenyl)pyrazolo[1,5-a]pyriMidin-7-yl)phenyl)-3-(trifluoroMethyl)benzaMide;BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-
CBNumber
CB52668351
Molecular Formula
C29H24F3N5O
Formula Weight
515.53
MOL File
950736-05-7.mol
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BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Property

Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 14 mg/ml; DMSO: 33 mg/ml; Ethanol: 1 mg/ml
pka
12.75±0.70(Predicted)
form 
Powder
color 
Light yellow to yellow
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23434
Product name
B-Raf Inhibitor 1
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
23434
Product name
B-Raf Inhibitor 1
Purity
≥98%
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
23434
Product name
B-Raf Inhibitor 1
Purity
≥98%
Packaging
10mg
Price
$477
Updated
2024/03/01
Cayman Chemical
Product number
23434
Product name
B-Raf Inhibitor 1
Purity
≥98%
Packaging
25mg
Price
$965
Updated
2024/03/01
TRC
Product number
D452005
Product name
N-[3-[3-[4-[(Dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide
Packaging
50mg
Price
$660
Updated
2021/12/16
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BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Chemical Properties,Usage,Production

Description

B-RAF IN 1 is an inhibitor of B-RAF (IC50 = 24 nM) that also inhibits C-RAF (IC50 = 25 nM). It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα, at concentrations greater than 2 μM, but does inhibit p38α and CAMKII (IC50s = 216 and 822 nM, respectively). B-RAF IN 1 binds to B-RAF in the inactive conformation based on co-crystallization with the wild-type enzyme. It inhibits proliferation of WM 266-4 and HT29 cells with IC50 values of 920 and 780 nM, respectively.

Uses

N-[3-[3-[4-[(Dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide is a potent and selective B-Raf inhibitor.

BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Suppliers

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View Lastest Price from BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- manufacturers

Career Henan Chemical Co
Product
BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- 950736-05-7
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-02-20

950736-05-7, BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-Related Search:

2-AZACYCLONONANONE Benzyl alcohol Acetoxyacetic acid Propionyl chloride Sodium benzoate Pyrrole Dimethyl sulfoxide Pyridine Benzoyl chloride

  • BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-
  • B-Raf IN 1
  • CS-1184
  • RAF-IN-10n
  • MDK36057
  • N-(3-(3-(4-((diMethylaMino)Methyl)phenyl)pyrazolo[1,5-a]pyriMidin-7-yl)phenyl)-3-(trifluoroMethyl)benzaMide
  • B-Raf IN 1, >=98%
  • B-Raf inhibit 1
  • Raf kinases,B-Raf IN 1,BRaf IN 1,Inhibitor,B Raf IN 1,Raf,inhibit
  • B-Raf IN 1, 10 mM in DMSO
  • 950736-05-7
  • C29H24F3N5O
  • Inhibitors