BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-

Product Name: BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-
CAS No.: 950736-05-7
Chemical Name: BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-
Synonyms: CS-1184;MDK36057;RAF-IN-10n;B-Raf IN 1;B-Raf inhibit 1;B-Raf IN 1, >=98%;Raf kinases,B-Raf IN 1,BRaf IN 1,Inhibitor,B Raf IN 1,Raf,inhibit;N-(3-(3-(4-((diMethylaMino)Methyl)phenyl)pyrazolo[1,5-a]pyriMidin-7-yl)phenyl)-3-(trifluoroMethyl)benzaMide;BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-
CBNumber: CB52668351
Molecular Formula: C29H24F3N5O
Formula Weight: 515.53
MOL File: 950736-05-7.mol

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BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Property

Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 14 mg/ml; DMSO: 33 mg/ml; Ethanol: 1 mg/ml
pka: 12.75±0.70(Predicted)
form: Powder
color: Light yellow to yellow

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23434
Product name: B-Raf Inhibitor 1
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 23434
Product name: B-Raf Inhibitor 1
Purity: ≥98%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 23434
Product name: B-Raf Inhibitor 1
Purity: ≥98%
Packaging: 10mg
Price: $477
Updated: 2024/03/01

Cayman Chemical

Product number: 23434
Product name: B-Raf Inhibitor 1
Purity: ≥98%
Packaging: 25mg
Price: $965
Updated: 2024/03/01

TRC

Product number: D452005
Product name: N-[3-[3-[4-[(Dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide
Packaging: 50mg
Price: $660
Updated: 2021/12/16

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BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Chemical Properties,Usage,Production

Description

B-RAF IN 1 is an inhibitor of B-RAF (IC₅₀ = 24 nM) that also inhibits C-RAF (IC₅₀ = 25 nM). It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα, at concentrations greater than 2 μM, but does inhibit p38α and CAMKII (IC₅₀s = 216 and 822 nM, respectively). B-RAF IN 1 binds to B-RAF in the inactive conformation based on co-crystallization with the wild-type enzyme. It inhibits proliferation of WM 266-4 and HT29 cells with IC₅₀ values of 920 and 780 nM, respectively.

Uses

N-[3-[3-[4-[(Dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)benzamide is a potent and selective B-Raf inhibitor.

BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- Suppliers

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View Lastest Price from BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- manufacturers

Career Henan Chemical Co

Product: BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)- 950736-05-7
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-02-20

950736-05-7, BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-Related Search:

2-AZACYCLONONANONE Benzyl alcohol Acetoxyacetic acid Propionyl chloride Sodium benzoate Pyrrole Dimethyl sulfoxide Pyridine Benzoyl chloride

BenzaMide, N-[3-[3-[4-[(diMethylaMino)Methyl]phenyl]pyrazolo[1,5-a]pyriMidin-7-yl]phenyl]-3-(trifluoroMethyl)-

B-Raf IN 1

CS-1184

RAF-IN-10n

MDK36057

N-(3-(3-(4-((diMethylaMino)Methyl)phenyl)pyrazolo[1,5-a]pyriMidin-7-yl)phenyl)-3-(trifluoroMethyl)benzaMide

B-Raf IN 1, >=98%

B-Raf inhibit 1

Raf kinases,B-Raf IN 1,BRaf IN 1,Inhibitor,B Raf IN 1,Raf,inhibit

950736-05-7

C29H24F3N5O

Inhibitors