AACOCF3

Product Name: AACOCF3
CAS No.: 149301-79-1
Chemical Name: AACOCF3
Synonyms: BPK;ATK;AGMX1;AATFMK;PSCTK1;AACOCF;AACOCF3;Arach-CF3;BTK active human;B cell progenitor kinase
CBNumber: CB5266861
Molecular Formula: C21H31F3O
Formula Weight: 356.47
MOL File: 149301-79-1.mol

More

Less

AACOCF3 Property

Boiling point:: 421.7±45.0 °C(Predicted)
Density: 0.981±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >5 mg/mL
form: liquid
color: yellow
Stability:: Light Sensitive

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A231
Product name: Arachidonyl trifluoromethyl ketone
Purity: oil, ≥97% (NMR)
Packaging: 5mg
Price: $482
Updated: 2024/03/01

Cayman Chemical

Product number: 62120
Product name: Arachidonyl Trifluoromethyl Ketone
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 62120
Product name: Arachidonyl Trifluoromethyl Ketone
Purity: ≥98%
Packaging: 1mg
Price: $8
Updated: 2021/12/16

Cayman Chemical

Product number: 62120
Product name: Arachidonyl Trifluoromethyl Ketone
Purity: ≥98%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 62120
Product name: Arachidonyl Trifluoromethyl Ketone
Purity: ≥98%
Packaging: 50mg
Price: $433
Updated: 2024/03/01

More

Less

AACOCF3 Chemical Properties,Usage,Production

Uses

Arachidonyl trifluoromethyl ketone (AACOCF3) has been used as a anandamide degradation inhibitor to study its effects in primary astrocyte cultures.

Definition

ChEBI: A fatty acid derivative that is arachidonic acid in which the OH part of the carboxy group has been replaced by a trifluoromethyl group

Biological Activity

Inhibitor of cytosolic (85 kDa) phospholipase A 2 . Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro .

Biochem/physiol Actions

Arachidonyl trifluoromethyl ketone (AACOCF3) plays a role in the inhibition of 12-hydroxyeicosatetraenoic acid (12-HETE) and thromboxane B2 produced by the platelets.

storage

-20°C (desiccate)

References

[1]. ackermann ej, conde-frieboes k, dennis ea. inhibition of macrophage ca(2+)-independent phospholipase a2 by bromoenol lactone and trifluoromethyl ketones. j biol chem, 1995, 270(1): 445-450.
[2]. riendeau d, guay j, weech pk, et al. arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kda phospholipase a2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. j biol chem, 1994, 269(22): 15619-15624.
[3]. malaviya r, ansell j, hall l, et al. targeting cytosolic phospholipase a2 by arachidonyl trifluoromethyl ketone prevents chronic inflammation in mice. eur j pharmacol, 2006, 539(3): 195-204.

AACOCF3 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AACOCF3 Suppliers

China 42 Germany 2 Japan 2 Switzerland 2 United Kingdom 2 United States 8 USA 1 Global 59

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18739
Advantage: 57

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9293
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

149301-79-1, AACOCF3Related Search:

Fullerene C70 ANANDAMIDE AACOCF3 (Cytosolic PLA2 Inhibitor) AACOCF3 2-ARACHIDONYL [5,6,8,9,11,12,14,15-3H], TRIFLUOROMETHYL KETONE

1,1,1-TRIFLUOROMETHYL-6,9,12,15-HEIEICOSATETRAEN-2-ONE

1,1,1-TRIFLUORO-6,9,12,15-HENEICOSATETRAEN-2-ONE

1,1,1-TRIFLUORO-6Z,9Z,12Z,15Z-HENEICOSATERAEN-2-ONE

1,1,1-TRIFLUORO-6Z,9Z-12Z,15Z-HENEICOSATETRAEN-2-ONE

AATFMK

AACOCF3

ARACHIDONYL TRIFLUOROMETHYL KETONE INHIB ITS ANANDAMIDE H

1,1,1-Trifluoromethyl-6,9,12,15-heieicosatetraen-2-one, AACOCF3, Arach-CF3

Arach-CF3

Bruton agammaglobulinemia tyrosine kinase

BTK active human

PSCTK1

AGMX1

Aγglobulinaemia tyrosine kinase

B cell progenitor kinase

BPK

6,9,12,15-Heneicosatetraen-2-one, 1,1,1-trifluoro-, (6Z,9Z,12Z,15Z)-

6,9,12,15-Heneicosatetraen-2-one, 1,1,1-trifluoro-, (all-Z)-

AACOCF

arachidonyltrifluoromethane

ATK

ARACHIDONIC ACID TRIFLUOROMETHYLKETONE

ARACHIDONOYL TRIFLUOROMETHYL KETONE

ARACHIDONYL TRIFLUOROMETHYLKETONE

Arachidonyl trifluoromethyl ketone oil, >=97% (NMR)

PDN01791，AACOCF3，Arachidonyl Trifluoromethyl Ketone

149301-79-1

C21H31F3O

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

Phospholipase A 2

P to Q

BioChemical

Biochemicals and Reagents

Lipid signaling