ANANDAMIDE
- Product Name
- ANANDAMIDE
- CAS No.
- 94421-68-8
- Chemical Name
- ANANDAMIDE
- Synonyms
- AEA;ARACHIDONOYL ETHANOLAMIDE;N-ARACHIDONOYLETHANOLAMINE;ARACHIDONYLETHANOLAMIDE;(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide;8Z;ANANDAMIDE;14-tetraenamide;ANANDAMIDE AEA?;anandamide(20.4,n-6)
- CBNumber
- CB7168648
- Molecular Formula
- C22H37NO2
- Formula Weight
- 347.53
- MOL File
- 94421-68-8.mol
ANANDAMIDE Property
- Boiling point:
- 522.3±50.0 °C(Predicted)
- Density
- 0.92 g/mL at 25 °C (lit.)
- Flash point:
- 14 °C
- storage temp.
- -20°C
- solubility
- ethanol: soluble
- form
- oil
- pka
- 14.48±0.10(Predicted)
- color
- light yellow
- Water Solubility
- 413ug/L(25 ºC)
- Stability:
- Stable for 1 year from date of purchase as supplied. Subject to oxidation – protect from air. Solutions in degassed DMSO or ethanol may be stored under nitrogen or argon at -80°C for up to 1 month.
Safety
- Hazard Codes
- F
- Risk Statements
- 11
- Safety Statements
- 24/25-16-7
- RIDADR
- UN 1170 3/PG 2
- WGK Germany
- 3
- RTECS
- JX3842500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- A0580
- Product name
- Arachidonylethanolamide
- Purity
- ≥97.0% (TLC), oil
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- A0580
- Product name
- Arachidonylethanolamide
- Purity
- ≥97.0% (TLC), oil
- Packaging
- 25mg
- Price
- $466
- Updated
- 2024/03/01
- Product number
- 90050
- Product name
- Arachidonoyl Ethanolamide
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 90050
- Product name
- Arachidonoyl Ethanolamide
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $76
- Updated
- 2024/03/01
- Product number
- 90050
- Product name
- Arachidonoyl Ethanolamide
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $296
- Updated
- 2024/03/01
ANANDAMIDE Chemical Properties,Usage,Production
Description
Anandamide (94421-68-8) is an endogenous cannabinoid receptor agonist.1-3?Ki=89 nM for CB1?and 371 nM for CB2?receptors.
Uses
Anandamide is an endogenous cannabinoid and TRPV1 receptor agonist. Findings suggest that endocannabinoids such as anandamide may help cause runner’s high, the feeling of euphoria, reduced anxiety and lessened ability to feel pain associated with exercise.
Definition
ChEBI: An N-(polyunsaturated fatty acyl)ethanolamine resulting from the formal condensation of carboxy group of arachidonic acid with amino group of ethanolamine.
Hazard
A reproductive hazard.
Biological Activity
Endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see TocrisolveTM 100). K i values are 89 and 371 nM for CB 1 and CB 2 receptors respectively; EC 50 values are 18, 31 and 27 nM at GPR55, CB 1 and CB 2 respectively; pK i = 5.68 for rVR1. Also blocks TNF- α -induced NF-kB activation via direct inhibition of IKK. Also available as the pure oil dissolved in ethanol (N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).
Biochem/physiol Actions
An arachidonic acid derivative that is an endogenous ligand for the CB cannabinoid receptor and for the VR1 vanilloid receptor. Inhibits calcium currents in neuroblastomas and neurons. Activates the MAP kinase signaling pathway. Inhibits proliferation and induces apoptosis of lymphocytes and human breast cancer cells.
Enzyme inhibitor
This lipid neurotransmitter and endocannabinoid receptor ligand (FW = 347.54 g/mol; CAS 94421-68-8), also known as arachidonylethanolamide, inhibits calcium ion currents and activates the MAP kinase signaling pathway. Anandamide is a naturally occurring effector of central and peripheral nervous systems, as mediated by CB1 and CB2 cannabinoid receptors, respectively. (These receptors were originally characterized as binding Δ9 -tetrahydrocannabinol, or THC, marijuana’s major psychoactive ingredient.) Anandamide, 2-arachidonoylglycerol, and congeners (N- oleoylethanolamide and N-palmitoylethanolamide) are lipophilic signalling molecules with multiple physiological roles in learning and memory, neuroinflammation, oxidative stress, neuroprotection and neurogenesis. Anandamide likewise plays a role in regulating uterine implantation of the early-stage embryo (blastocyst). Anandamide synthesis occurs from N- acetylphosphatidylethanolamine by multiple pathways that include phospholipase A2, phospholipase C, and NAPE-hydrolyzing phospholipase D (or NAPE-PLD). Target(s): adenylate cyclase; Na + channels; a7-nicotinic acetylcholine receptor; 5 HT3 receptors; Ca 2+ channels; K+ channels, voltage-gated; acylglycerol lipase, or monoacylglycerol lipase.
storage
Store at -20°C
References
1) Devane?et al. (1992),?Isolation and structure of a brain constituent that binds to the cannabinoid receptor; Science,258?1946 2) Devane?et al. (1994),?New dawn of cannabinoid pharmacology; Trends Pharmacol.Sci.,?15?40 3) Hillard?et al. (1997),?Biochemistry and pharmacology of arachidonoylethanolamide, a putative endogenous cannabinoid; J. Lipid Res.,?38?2383
ANANDAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ANANDAMIDE manufacturers
- Product
- ANANDAMIDE AEA 94421-68-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000kg
- Release date
- 2023-11-14
- Product
- Anandamide
- Price
- US $32.00-20.00/kg
- Min. Order
- 1kg
- Purity
- 99.50%
- Supply Ability
- 20tons
- Release date
- 2023-07-05
- Product
- Arachidonylethanolamide 94421-68-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 50000tons
- Release date
- 2023-05-17