ChemicalBook > CAS DataBase List > SGC-CBP30

SGC-CBP30

Product Name
SGC-CBP30
CAS No.
1613695-14-9
Chemical Name
SGC-CBP30
Synonyms
CS-993;SGCBP30;CS-1923;SGC-CBP30;SGCBP30;SGCCBP 30;SGCCBP30;SGC CBP30;SGC-CBP30 USP/EP/BP;(S)-4-(1-(2-(3-Chloro-4-methoxyphenethyl)-5-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-1-;2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole;1H-Benzimidazole, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-
CBNumber
CB52670792
Molecular Formula
C28H33ClN4O3
Formula Weight
509.04
MOL File
1613695-14-9.mol
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SGC-CBP30 Property

Boiling point:
678.0±55.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
≥20.05 mg/mL in DMSO; ≥25.7 mg/mL in EtOH with ultrasonic; ≥4.67 mg/mL in H2O with ultrasonic
form 
powder
pka
6.98±0.10(Predicted)
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1133
Product name
SGC-CBP30
Purity
≥98% (HPLC)
Packaging
5mg
Price
$160
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1133
Product name
SGC-CBP30
Purity
≥98% (HPLC)
Packaging
25mg
Price
$634
Updated
2024/03/01
Cayman Chemical
Product number
14469
Product name
SGC-CBP30
Purity
≥98%
Packaging
5mg
Price
$110
Updated
2024/03/01
Cayman Chemical
Product number
14469
Product name
SGC-CBP30
Purity
≥98%
Packaging
10mg
Price
$208
Updated
2024/03/01
Cayman Chemical
Product number
14469
Product name
SGC-CBP30
Purity
≥98%
Packaging
50mg
Price
$812
Updated
2024/03/01
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SGC-CBP30 Chemical Properties,Usage,Production

Description

SGC-CBP30 is a potent CBP/p300 bromodomain (BRD) inhibitor. SGC-CBP30 shows Kd values are 21 and 32 nM for CBP and p300 BRDs respectively. SGC-CBP30 also exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. SGC-CBP30 accelerates FRAP recovery in cells at a concentration of 1 ?M.

Uses

SGC-CBP30 is a potent CREBBP/EP300 inhibitor.

Biochem/physiol Actions

SGC-CBP30 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.021 and 0.038 μM, respectively). SGC-CBP30 has little activity against other bromodomains at concentrations up to 1 mM. For full characterization details, please visit the SGC-CBP30 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

target

CREBBP

storage

Store at +4°C

SGC-CBP30 Preparation Products And Raw materials

Raw materials

Preparation Products

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SGC-CBP30 Suppliers

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DKMbiochem.Co. Ltd
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View Lastest Price from SGC-CBP30 manufacturers

Career Henan Chemica Co
Product
SGC-CBP30 1613695-14-9
Price
US $9.80-8.00/KG
Min. Order
1KG
Purity
95%~99.99%
Supply Ability
10 MT/ Month
Release date
2020-10-28

1613695-14-9, SGC-CBP30Related Search:

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  • SGC-CBP30
  • 2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole
  • 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole SGC-CBP30
  • 2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole
  • 2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole
  • (S)-4-(1-(2-(3-Chloro-4-methoxyphenethyl)-5-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-1-
  • CS-1923
  • SGCBP30
  • SGCBP30;SGCCBP 30
  • CS-993
  • SGCCBP30;SGC CBP30
  • 1H-Benzimidazole, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-
  • SGC-CBP30 USP/EP/BP
  • (S)-4-(1-(2-(3-Chloro-4-methoxyphenethyl)-5-(3,5-dimethylisoxazol-4-yl)-1H-benzo[d]imidazol-1-yl)propan-2-yl)morpholine
  • inhibit,IL-17A,HAT,HATs,BRD,Histone Acetyltransferase,ankylosing,SGCCBP30,cells,epigenetic,spondylitis,anti-inflammatory,arthritis,SGC-CBP30,Epigenetic Reader Domain,SGC-CBP-30,Th17,psoriatic,SGC CBP30,Inhibitor
  • 1613695-14-9
  • C28H33ClN4O3
  • Inhibitors