BroMosporine

Background

Product Name: BroMosporine
CAS No.: 1619994-69-2
Chemical Name: BroMosporine
Synonyms: CS-921;BroMosporine;BroMosporine USP/EP/BP;Bromosporine, 10 mM in DMSO;KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4;N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate;ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate;Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester;11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase
CBNumber: CB52676961
Molecular Formula: C17H20N6O4S
Formula Weight: 404.44
MOL File: 1619994-69-2.mol

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BroMosporine Property

Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 25 mg/ml)
pka: 6.21±0.46(Predicted)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI: 1S/C17H20N6O4S/c1-5-27-17(24)18-15-9-14(21-23-11(3)19-20-16(15)23)12-7-6-10(2)13(8-12)22-28(4,25)26/h6-9,22H,5H2,1-4H3,(H,18,24)
InChIKey: UYBRROMMFMPJAN-UHFFFAOYSA-N
SMILES: CC(C(NS(C)(=O)=O)=C1)=CC=C1C2=NN3C(C(NC(OCC)=O)=C2)=NN=C3C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0992
Product name: Bromosporine
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $191
Updated: 2026/03/19

Cayman Chemical

Product number: 14119
Product name: Bromosporine
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 14119
Product name: Bromosporine
Purity: ≥98%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 14119
Product name: Bromosporine
Purity: ≥98%
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 14119
Product name: Bromosporine
Purity: ≥98%
Packaging: 25mg
Price: $353
Updated: 2024/03/01

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BroMosporine Chemical Properties,Usage,Production

Description

Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1Bromosporine was able to reactivate HIV-1 replication in different latency models.2

Uses

Bromosporine is a broad spectrum inhibitor for bromodomains.

in vivo

Bromosporine (100 mg/kg; i.p.; daily for 10 days) shows better antitumor activity than individual when co-treated with 5-Fluorouracil.html" class="link-product" target="_blank">5-FU (HY-90006)^[1].

Animal Model:	Female BALB/c nude mice (5-6 weeks; injected with 1×10⁶cells/100μL of HT116cells)^[1]
Dosage:	100 mg/kg
Administration:	i.p.; daily for 10 days
Result:	Exhibited better antitumor activity than individual Bromosporine or 5-FU (HY-90006) when co-treated with the two agent.

target

bromodomain

IC 50

HIV-1

storage

Store at +4°C

Background

Bromosporine is a potent broad-spectrum bromodomain inhibitor. Bromodomain and extra-terminal protein family members BRD2, BRD3, BRD4, and BRDT associate with acetylated lysines on histones and transcription factors to regulate their function, and have emerged as targets for cancer therapy. Treatment with Bromosporine induced the expression of latent HIV-1 in primary CD4+ T cells by inhibiting BET activity, leading to improved viral clearance in conjunction with antiretroviral therapy.

References

[1] SARAH PICAUD. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia[J]. Science Advances, 2016, 2 10. DOI:10.1126/sciadv.1600760
[2] HANYU PAN. The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells.[J]. Oncotarget, 2017: 94104-94116. DOI:10.18632/oncotarget.21585

BroMosporine Preparation Products And Raw materials

Raw materials

Preparation Products

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BroMosporine Suppliers

China 90 India 1 United Kingdom 1 United States 17 Global 109

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3566
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Shenzhen Nexconn Pharmatechs Ltd.

Tel: 0755-89396905
Fax: 0755-22712255
Email: admin@nexconn.com
Country: China
ProdList: 299
Advantage: 55

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4345
Advantage: 55

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View Lastest Price from BroMosporine manufacturers

Career Henan Chemical Co

Product: BroMosporine 1619994-69-2
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

1619994-69-2, BroMosporineRelated Search:

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BroMosporine

ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate

N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate

CS-921

Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester

BroMosporine USP/EP/BP

11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase

KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4

Bromosporine, 10 mM in DMSO

1619994-69-2

Inhibitors

API