BroMosporine

Product Name: BroMosporine
CAS No.: 1619994-69-2
Chemical Name: BroMosporine
Synonyms: CS-921;BroMosporine;BroMosporine USP/EP/BP;Bromosporine, 10 mM in DMSO;KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4;N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate;ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate;Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester;11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase
CBNumber: CB52676961
Molecular Formula: C17H20N6O4S
Formula Weight: 404.44
MOL File: 1619994-69-2.mol

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BroMosporine Property

Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 25 mg/ml)
pka: 6.21±0.46(Predicted)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0992
Product name: Bromosporine
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $178
Updated: 2025/07/31

Cayman Chemical

Product number: 14119
Product name: Bromosporine
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 14119
Product name: Bromosporine
Purity: ≥98%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 14119
Product name: Bromosporine
Purity: ≥98%
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 14119
Product name: Bromosporine
Purity: ≥98%
Packaging: 25mg
Price: $353
Updated: 2024/03/01

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BroMosporine Chemical Properties,Usage,Production

Description

Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1?Bromosporine was able to reactivate HIV-1 replication in different latency models.2

Uses

Bromosporine is a broad spectrum inhibitor for bromodomains.

in vivo

Bromosporine (100 mg/kg; i.p.; daily for 10 days) shows better antitumor activity than individual when co-treated with 5-Fluorouracil.html" class="link-product" target="_blank">5-FU (HY-90006)^[1].

Animal Model:	Female BALB/c nude mice (5-6 weeks; injected with 1?×?10⁶?cells/100?μL of HT116?cells)^[1]
Dosage:	100 mg/kg
Administration:	i.p.; daily for 10 days
Result:	Exhibited better antitumor activity than individual Bromosporine or 5-FU (HY-90006) when co-treated with the two agent.

target

bromodomain

IC 50

HIV-1

storage

Store at +4°C

References

[1] SARAH PICAUD. Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia[J]. Science Advances, 2016, 2 10. DOI:10.1126/sciadv.1600760
[2] HANYU PAN. The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells.[J]. Oncotarget, 2017: 94104-94116. DOI:10.18632/oncotarget.21585

BroMosporine Preparation Products And Raw materials

Raw materials

Preparation Products

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BroMosporine Suppliers

China 90 India 1 United Kingdom 1 United States 17 Global 109

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
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Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
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Shenzhen Nexconn Pharmatechs Ltd.

Tel: 0755-89396905
Email: admin@nexconn.com
Country: China
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AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
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Email: info@adooq.cn
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LETOPHARM LIMITED

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Fax: +86-21-5106 2861
Email: sales@letopharm.com
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Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4456
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D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
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View Lastest Price from BroMosporine manufacturers

Career Henan Chemical Co

Product: BroMosporine 1619994-69-2
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

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BroMosporine

ethyl 3-Methyl-6-(4-Methyl-3-(MethylsulfonaMido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-ylcarbaMate

N-[6-(3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate

CS-921

Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester

BroMosporine USP/EP/BP

11,Bromosporine,inhibit,AML,colorectal cancer,CDK,antitumor,T cells,HCT116,Apoptosis,HT29,anticancer,Epigenetic Reader Domain,Inhibitor,Cyclin dependent kinase

KASUMI-1,HIV,AIDS,Human immunodeficiency virus,MV4

Bromosporine, 10 mM in DMSO

1619994-69-2

Inhibitors

API