ChemicalBook > CAS DataBase List > Arginase inhibitor 1

Arginase inhibitor 1

Product Name
Arginase inhibitor 1
CAS No.
1345808-25-4
Chemical Name
Arginase inhibitor 1
Synonyms
Arginase inhibitor 1;1-Piperidinebutanoic acid, α-amino-α-(4-boronobutyl)-, (αR)-;(alphaR)-alpha-Amino-alpha-(4-boronobutyl)-1-piperidinebutanoic acid
CBNumber
CB52677054
Molecular Formula
C13H27BN2O4
Formula Weight
286.18
MOL File
1345808-25-4.mol
More
Less

Arginase inhibitor 1 Property

Boiling point:
523.0±60.0 °C(Predicted)
Density 
1.147±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: 50 mg/ml; Water: 30 mg/ml
form 
Powder
pka
2.22±0.44(Predicted)
color 
White to gray
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28418
Product name
Arginase Inhibitor 1
Packaging
1mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
28418
Product name
Arginase Inhibitor 1
Packaging
5mg
Price
$684
Updated
2024/03/01
ApexBio Technology
Product number
B1009
Product name
Arginaseinhibitor1
Packaging
2mg
Price
$252
Updated
2021/12/16
AK Scientific
Product number
1379DT
Product name
Arginaseinhibitor1
Packaging
1mg
Price
$268
Updated
2021/12/16
ChemScene
Product number
CS-1736
Product name
Arginaseinhibitor1
Purity
98.00%
Packaging
5mg
Price
$288
Updated
2021/12/16
More
Less

Arginase inhibitor 1 Chemical Properties,Usage,Production

Description

Arginase inhibitor 1 is an inhibitor of arginase I and II (IC50s = 223 and 509 nM, respectively, for the recombinant human enzymes). It decreases arginase I activity in CHOK cells expressing human arginase I (IC50 = 8 μM). Arginase inhibitor 1 (100 mg/kg, i.v.) reduces infarct size in a rat model of myocardial ischemia and reperfusion injury induced by left-main coronary artery occlusion.

Uses

Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.

in vivo

Following i.v. dosing with 10 mg/kg in fasted animals, Arginase inhibitor 1has a terminal elimination half-life (t1/2) of 3.3 h with a volume of distribution and total body clearance of 1.86 L/kg and 7.89 mL/min/kg, respectively. The oral bioavailability of Arginase inhibitor 1 (10 mg/kg, p.o.) is 28% with a Cmax of 0.45 mg/L[1].

References

[1] Van Zandt MC, et al. Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potentinhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem. 2013 Mar 28;56(6):2568-80. DOI:10.1021/jm400014c

Arginase inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Arginase inhibitor 1 Suppliers

China 40 United States 9 Global 49
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1345808-25-4, Arginase inhibitor 1Related Search:

Zinc dibutyldithiocarbamate DibutylCarbamodithioic acid sodium salt

  • Arginase inhibitor 1
  • (alphaR)-alpha-Amino-alpha-(4-boronobutyl)-1-piperidinebutanoic acid
  • 1-Piperidinebutanoic acid, α-amino-α-(4-boronobutyl)-, (αR)-
  • 1345808-25-4
  • C13H27BN2O4