(S)-b-AMino-4-Methoxy-benzeneethanol
- Product Name
- (S)-b-AMino-4-Methoxy-benzeneethanol
- CAS No.
- 191109-48-5
- Chemical Name
- (S)-b-AMino-4-Methoxy-benzeneethanol
- Synonyms
- (S)-p-hydroxyphenylglycinol;(S)-b-AMino-4-Methoxy-benzeneethanol;(S)-2-Amino-2-(4-methoxyphenyl)ethanol;(S)-2-Amino-2-(4-methoxyphenyl)ethan-1-ol;Benzeneethanol, β-amino-4-methoxy-, (βS)-;(2S)-2-AMINO-2-(4-METHOXYPHENYL)ETHAN-1-OL;(S)-2-amino-2-(4-methoxyphenyl)ethanol hydrochloride
- CBNumber
- CB52684223
- Molecular Formula
- C9H13NO2
- Formula Weight
- 167.21
- MOL File
- 191109-48-5.mol
(S)-b-AMino-4-Methoxy-benzeneethanol Property
- Boiling point:
- 325.4±32.0 °C(Predicted)
- Density
- 1.128±0.06 g/cm3(Predicted)
- pka
- 12.54±0.10(Predicted)
Safety
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CCH0030554
- Product name
- (2S)-2-AMINO-2-(4-METHOXYPHENYL)ETHAN-1-OL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.77
- Updated
- 2021/12/16
- Product number
- 191109485
- Product name
- (S)-2-Amino-2-(4-methoxyphenyl)ethanol
- Packaging
- 1g
- Price
- $539
- Updated
- 2021/12/16
- Product number
- CD12101137
- Product name
- (S)-2-Amino-2-(4-methoxyphenyl)ethanol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $607
- Updated
- 2021/12/16
- Product number
- 191109485
- Product name
- (S)-2-Amino-2-(4-methoxyphenyl)ethanol
- Packaging
- 5g
- Price
- $960.4
- Updated
- 2021/12/16
- Product number
- CM279271
- Product name
- (S)-2-Amino-2-(4-methoxyphenyl)ethanol
- Purity
- 95%
- Packaging
- 5g
- Price
- $1141
- Updated
- 2021/12/16
(S)-b-AMino-4-Methoxy-benzeneethanol Chemical Properties,Usage,Production
Physical properties
A white crystal
Uses
(S)-2-Amino-2-(4-methoxyphenyl)ethanol hydrochloride is used as an intermediate in laboratory research.
Reactions
(S)-b-AMino-4-Methoxy-benzeneethanol could synthize oxidatively
cleavable chiral auxiliary-bearing tetramate derivative 1-[(S)-2-Hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-3-methyl-1H-pyrrol2(5H)-one with (E)-4-bromo-3-methoxy-2-methyl-2-butenoate. Due to its chirality, it can also be used to synthesize various chiral organics, such as 1-[(S) -2-hydroxy-1 -(4-methoxyphenyl)ethyl] -4-methoxy-3-methyl-1h-Pyrrol2 (5H)-one[1-2].
Synthesis
1.To an ice-cooled mixture of lithium borohydride (16.5 g, 759 mmol) in THF (270 mL) was added trimethylsilyl chloride (194 mL, 1.52 mol).
2.After stirring for 30 minutes, a mixture of (2S)-2-amino-2-(4-methoxyphenyl)acetic acid (45.9 g, 253 mmol) in THF (1.00 L) was added dropwise to the reaction.
3.Then the reaction mixture was stirred at rt overnight.
4.The reaction was quenched with MeOH, and the resulting mixture was concentrated in vacuo.The residue was diluted with 1M sodium hydroxide aq.solution and chloroform, and filtered through a pad of Celite.
5.The filtrate was diluted with brine, and organic layer was separated. The aqueous layer was extracted with chloroform. The combined organic extracts were dried over sodium sulfate, filtered, and concentrated in vacuo to give (S)-b-AMino-4-Methoxy-benzeneethanol (37.1 g) as red solids.
References
[1] Lan H, et al. The first enantioselective synthesis of cytotoxic marine natural product palau’imide and assignment of its C-20 stereochemistry. Chemical Communications, 2010; 46: 5319-532.
[2] Shemet A, et al. Total Synthesis of (?)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution. Organic Letters, 2017; 19: 5529–5532.
(S)-b-AMino-4-Methoxy-benzeneethanol Preparation Products And Raw materials
Raw materials
Preparation Products
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