ChemicalBook > CAS DataBase List > (S)-b-AMino-4-Methoxy-benzeneethanol

(S)-b-AMino-4-Methoxy-benzeneethanol

Product Name
(S)-b-AMino-4-Methoxy-benzeneethanol
CAS No.
191109-48-5
Chemical Name
(S)-b-AMino-4-Methoxy-benzeneethanol
Synonyms
(S)-p-hydroxyphenylglycinol;(S)-b-AMino-4-Methoxy-benzeneethanol;(S)-2-Amino-2-(4-methoxyphenyl)ethanol;(S)-2-Amino-2-(4-methoxyphenyl)ethan-1-ol;Benzeneethanol, β-amino-4-methoxy-, (βS)-;(2S)-2-AMINO-2-(4-METHOXYPHENYL)ETHAN-1-OL;(S)-2-amino-2-(4-methoxyphenyl)ethanol hydrochloride
CBNumber
CB52684223
Molecular Formula
C9H13NO2
Formula Weight
167.21
MOL File
191109-48-5.mol
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(S)-b-AMino-4-Methoxy-benzeneethanol Property

Boiling point:
325.4±32.0 °C(Predicted)
Density 
1.128±0.06 g/cm3(Predicted)
pka
12.54±0.10(Predicted)
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Safety

HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CCH0030554
Product name
(2S)-2-AMINO-2-(4-METHOXYPHENYL)ETHAN-1-OL
Purity
95.00%
Packaging
5MG
Price
$505.77
Updated
2021/12/16
Alichem
Product number
191109485
Product name
(S)-2-Amino-2-(4-methoxyphenyl)ethanol
Packaging
1g
Price
$539
Updated
2021/12/16
Crysdot
Product number
CD12101137
Product name
(S)-2-Amino-2-(4-methoxyphenyl)ethanol
Purity
95+%
Packaging
1g
Price
$607
Updated
2021/12/16
Alichem
Product number
191109485
Product name
(S)-2-Amino-2-(4-methoxyphenyl)ethanol
Packaging
5g
Price
$960.4
Updated
2021/12/16
Chemenu
Product number
CM279271
Product name
(S)-2-Amino-2-(4-methoxyphenyl)ethanol
Purity
95%
Packaging
5g
Price
$1141
Updated
2021/12/16
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(S)-b-AMino-4-Methoxy-benzeneethanol Chemical Properties,Usage,Production

Physical properties

A white crystal

Uses

(S)-2-Amino-2-(4-methoxyphenyl)ethanol hydrochloride is used as an intermediate in laboratory research.

Reactions

(S)-b-AMino-4-Methoxy-benzeneethanol could synthize oxidatively cleavable chiral auxiliary-bearing tetramate derivative 1-[(S)-2-Hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-3-methyl-1H-pyrrol2(5H)-one with (E)-4-bromo-3-methoxy-2-methyl-2-butenoate. Due to its chirality, it can also be used to synthesize various chiral organics, such as 1-[(S) -2-hydroxy-1 -(4-methoxyphenyl)ethyl] -4-methoxy-3-methyl-1h-Pyrrol2 (5H)-one[1-2].
 

Synthesis

1.To an ice-cooled mixture of lithium borohydride (16.5 g, 759 mmol) in THF (270 mL) was added trimethylsilyl chloride (194 mL, 1.52 mol).
2.After stirring for 30 minutes, a mixture of (2S)-2-amino-2-(4-methoxyphenyl)acetic acid (45.9 g, 253 mmol) in THF (1.00 L) was added dropwise to the reaction.
3.Then the reaction mixture was stirred at rt overnight.
4.The reaction was quenched with MeOH, and the resulting mixture was concentrated in vacuo.The residue was diluted with 1M sodium hydroxide aq.solution and chloroform, and filtered through a pad of Celite.
5.The filtrate was diluted with brine, and organic layer was separated. The aqueous layer was extracted with chloroform. The combined organic extracts were dried over sodium sulfate, filtered, and concentrated in vacuo to give (S)-b-AMino-4-Methoxy-benzeneethanol (37.1 g) as red solids.

References

[1] Lan H, et al. The first enantioselective synthesis of cytotoxic marine natural product palau’imide and assignment of its C-20 stereochemistry. Chemical Communications, 2010; 46: 5319-532.
[2] Shemet A, et al. Total Synthesis of (?)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution. Organic Letters, 2017; 19: 5529–5532.

(S)-b-AMino-4-Methoxy-benzeneethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-b-AMino-4-Methoxy-benzeneethanol Suppliers

Tianjin Xinghan Biotechnology Co., Ltd
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13230698506 18698089028
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China
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Amatek Scientific Co. Ltd.
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LABTER PHARMATECH(BEIJING) CO.,LTD
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BePharm Ltd
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Amadis Chemical Company Limited
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Shanghai CR Corporation Limited
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Amatek Scientific Co. Ltd.
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0512-56316828
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Mirro Chemical Co.,Ltd.
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Aikon International Limited
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025-66028182 18112977050
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Bejing Famous Pharmaceutical Technology Co., Ltd.
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191109-48-5, (S)-b-AMino-4-Methoxy-benzeneethanolRelated Search:


  • (S)-b-AMino-4-Methoxy-benzeneethanol
  • (2S)-2-AMINO-2-(4-METHOXYPHENYL)ETHAN-1-OL
  • (S)-2-Amino-2-(4-methoxyphenyl)ethanol
  • (S)-p-hydroxyphenylglycinol
  • (S)-2-amino-2-(4-methoxyphenyl)ethanol hydrochloride
  • Benzeneethanol, β-amino-4-methoxy-, (βS)-
  • (S)-2-Amino-2-(4-methoxyphenyl)ethan-1-ol
  • 191109-48-5