tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate
- Product Name
- tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate
- CAS No.
- 558442-96-9
- Chemical Name
- tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate
- Synonyms
- 105471;tert-butyl N-(4-morpholinocyclohexyl)carbamate;tert-Butyl (trans-4-morpholinocyclohexyl)carbamate;tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate;Carbamic acid, N-[trans-4-(4-morpholinyl)cyclohexyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB52684445
- Molecular Formula
- C15H28N2O3
- Formula Weight
- 284.39
- MOL File
- 558442-96-9.mol
tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Property
- Boiling point:
- 396.3±37.0 °C(Predicted)
- Density
- 1.07±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 12.50±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 120887
- Product name
- tert-Butyl((1r,4r)-4-morpholinocyclohexyl)-carbamate
- Purity
- 97%
- Packaging
- 5g
- Price
- $1486
- Updated
- 2021/12/16
- Product number
- 120887
- Product name
- tert-Butyl((1r,4r)-4-morpholinocyclohexyl)-carbamate
- Purity
- 97%
- Packaging
- 10g
- Price
- $2376
- Updated
- 2021/12/16
- Product number
- CD11104477
- Product name
- tert-Butyl(trans-4-morpholinocyclohexyl)carbamate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $1882
- Updated
- 2021/12/16
- Product number
- 558442969
- Product name
- tert-Butyl(trans-4-morpholinocyclohexyl)carbamate
- Packaging
- 10g
- Price
- $1996.05
- Updated
- 2021/12/16
- Product number
- A123528
- Product name
- tert-Butyl(trans-4-morpholinocyclohexyl)carbamate
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $89
- Updated
- 2021/12/16
tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Chemical Properties,Usage,Production
Synthesis
5414-19-7
177906-48-8
558442-96-9
The general procedure for the synthesis of tert-butyl (trans-4-morpholinocyclohexyl)carbamate from 2,2'-dibromodiethyl ether and tert-butyl trans-(4-aminocyclohexyl)carbamate was as follows: 21.43 g (0.1 mol) of tert-butyl N-(trans-4-aminocyclohexyl)carbamate was dissolved into 250 mL of N,N-dimethylformamide, followed by addition of 16.76 mL (0.12 mol) bis(2-bromoethyl) ether and 34.85 mL (0.25 mol) triethylamine. The reaction mixture was stirred at 70°C for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate, and the organic layer was washed sequentially with aqueous sodium carbonate and saturated brine solution, and then dried over anhydrous sodium sulfate. The solvent was again removed by reduced pressure distillation and the residue was purified by silica gel column chromatography (elution gradient: from pure chloroform to chloroform/methanol=30/1) to give 19.92 g (70% yield) of tert-butyl (trans-4-morpholino cyclohexyl)carbamate.
References
[1] Patent: EP1775298, 2007, A1. Location in patent: Page/Page column 33-34
tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Suppliers
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