IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester
- Product Name
- IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester
- CAS No.
- 1286754-14-0
- Chemical Name
- IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester
- Synonyms
- Ethyl imidazo[1,2-a]pyrazine-3-carboxylate;Imidazo[1,2-a]pyrazine-3-carboxylic acid ethyl ester;Midazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester;IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester
- CBNumber
- CB52686580
- Molecular Formula
- C9H9N3O2
- Formula Weight
- 191.19
- MOL File
- 1286754-14-0.mol
IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester Property
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.50±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
N-Bromosuccinimide Price
- Product number
- E938715
- Product name
- Ethylimidazo[1,2-a]pyrazine-3-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E938715
- Product name
- Ethylimidazo[1,2-a]pyrazine-3-carboxylate
- Packaging
- 100mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- CS-0036829
- Product name
- Ethylimidazo[1,2-a]pyrazine-3-carboxylate
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $348
- Updated
- 2021/12/16
- Product number
- CS-0036829
- Product name
- Ethylimidazo[1,2-a]pyrazine-3-carboxylate
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 9739AL
- Product name
- Ethylimidazo[1,2-a]pyrazine-3-carboxylate
- Packaging
- 100mg
- Price
- $151
- Updated
- 2021/12/16
IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
5049-61-6
70-23-5
1286754-14-0
The general procedure for the synthesis of ethyl imidazo[1,2-a]pyrazine-3-carboxylate from pyrazin-2-amine (1 g, 10 mmol) and ethyl 3-bromo-2-oxopropanoate (2.30 g, 12 mmol) was as follows: pyrazin-2-amine was dissolved in 50 mL of ethylene glycol dimethyl ether, followed by the addition of 50 mL of methanol and ethyl 3-bromo-2-oxopropanoate. The reaction mixture was stirred at room temperature for 4 hours, then cooled to 0 °C and continued stirring for 30 minutes until the solid precipitated. The solid was separated by filtration and the filter cake was washed with ether (10 mL x 3). The resulting solid was dissolved in 50 mL of anhydrous ethanol and the solution was refluxed for 4 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, 100 mL of dichloromethane was added, and the organic layer was washed sequentially with saturated sodium carbonate solution (40 mL) and saturated sodium chloride solution (40 mL). The organic layer was dried with anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure to give ethyl imidazo[1,2-a]pyrazine-3-carboxylate (0.55 g, 28.9% yield) as a brown solid. Mass spectrometry analysis (ESI): m/z 192.1 [M+H]+.
References
[1] Patent: EP2604610, 2013, A1. Location in patent: Paragraph 0121; 0122
IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester manufacturers
- Product
- IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester 1286754-14-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-21