Methyl imidazo[1,2-a]pyridine-8-carboxylate
- Product Name
- Methyl imidazo[1,2-a]pyridine-8-carboxylate
- CAS No.
- 133427-07-3
- Chemical Name
- Methyl imidazo[1,2-a]pyridine-8-carboxylate
- Synonyms
- 8-(Methoxycarbonyl)imidazo[1,2-a]pyridine;Methyl imidazo[1,2-a]pyridine-8-carboxylate;METHYL H-IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLATE;IMidazo[1,2-a]pyridine-8-carboxylic acid, Methyl ester;IMidazo[1,2-a]pyridine-8-carboxylicacidMethylesterhydrochloride
- CBNumber
- CB51263461
- Molecular Formula
- C9H8N2O2
- Formula Weight
- 176.17
- MOL File
- 133427-07-3.mol
Methyl imidazo[1,2-a]pyridine-8-carboxylate Property
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.00±0.50(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M324975
- Product name
- MethylImidazo[1,2-A]pyridine-8-carboxylate
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- J94672
- Product name
- Methylimidazo[1,2-a]pyridine-8-carboxylate
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 6076AA
- Product name
- Methylimidazo[1,2-a]pyridine-8-carboxylate
- Packaging
- 1g
- Price
- $119
- Updated
- 2021/12/16
- Product number
- 6076AA
- Product name
- Methylimidazo[1,2-a]pyridine-8-carboxylate
- Packaging
- 5g
- Price
- $368
- Updated
- 2021/12/16
- Product number
- J94672
- Product name
- Methylimidazo[1,2-a]pyridine-8-carboxylate
- Packaging
- 10g
- Price
- $416
- Updated
- 2021/12/16
Methyl imidazo[1,2-a]pyridine-8-carboxylate Chemical Properties,Usage,Production
Uses
Imidazo[1,2-a]pyridine-8-carboxylic acid methyl ester HCl
Synthesis
14667-47-1
133603-12-0
133427-07-3
Example 1: Synthesis of methyl methylimidazo[1,2-a]pyridine-8-carboxylate (Compound No. 1-1) A 47% aqueous hydrogen bromide solution (2.5 mL, 14.4 mmol) was slowly added to diethoxyethidium bromide (2.0 mL, 13.2 mmol), and the reaction mixture was stirred at 50 °C for 2 hours. After the reaction was completed, the mixture was cooled to room temperature, ethanol (7.0 mL) and sodium bicarbonate (1.0 g, 11.9 mmol) were added sequentially, stirred and mixed, and the insoluble material was filtered off. To the filtrate was added methyl 2-aminonicotinate (1.0 g, 6.6 mmol), sodium bicarbonate (2.0 g, 13.8 mmol) and ethanol (7.0 mL), and the mixture was heated to reflux for 4 hours. At the end of the reaction, the mixture was cooled to room temperature, and the pH was adjusted by adding saturated aqueous sodium bicarbonate solution. extraction was carried out with dichloromethane (100 mL×3), and the organic phases were combined, washed with water, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure. The crude product obtained was purified by silica gel column chromatography (eluent: chloroform, followed by chloroform/methanol=9/1) to obtain methyl imidazo[1,2-a]pyridine-8-carboxylate (0.6 g, 55% yield) as yellow crystals, melting point 67-69°C. The product was extracted with dichloromethane (100 mL×3) and dried with water.
References
[1] Patent: US5498774, 1996, A
Methyl imidazo[1,2-a]pyridine-8-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl imidazo[1,2-a]pyridine-8-carboxylate manufacturers
- Product
- Methyl imidazo[1,2-a]pyridine-8-carboxylate 133427-07-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-06
- Product
- Methyl imidazo[1,2-a]pyridine-8-carboxylate 133427-07-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09