8-METHYLIMIDAZO[1,2-A]PYRIDINE

Product Name: 8-METHYLIMIDAZO[1,2-A]PYRIDINE
CAS No.: 874-10-2
Chemical Name: 8-METHYLIMIDAZO[1,2-A]PYRIDINE
Synonyms: 8-methyl-imidazolopyrimidine;8-METHYLIMIDAZO[1,2-A]PYRIDINE;Imidazo[1,2-a]pyridine, 8-methyl-
CBNumber: CB5246663
Molecular Formula: C8H8N2
Formula Weight: 132.16
MOL File: 874-10-2.mol

More

Less

8-METHYLIMIDAZO[1,2-A]PYRIDINE Property

Boiling point:: 69°C 0,1mm
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.33±0.50(Predicted)
Appearance: Brown to black Liquid

More

Less

Safety

Risk Statements: 43
Safety Statements: 36/37
HazardClass: IRRITANT
HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 045473
Product name: 8-Methylimidazo[1,2-a]pyridine
Purity: 95+%
Packaging: 500mg
Price: $97
Updated: 2021/12/16

Matrix Scientific

Product number: 045473
Product name: 8-Methylimidazo[1,2-a]pyridine
Purity: 95+%
Packaging: 1g
Price: $149
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-CH
Product name: 8-Methylimidazo[1,2-a]pyridine
Packaging: 1g
Price: $176
Updated: 2021/12/16

AK Scientific

Product number: 3834AC
Product name: 8-Methylimidazo[1,2-a]pyridine
Packaging: 1g
Price: $195
Updated: 2021/12/16

Matrix Scientific

Product number: 045473
Product name: 8-Methylimidazo[1,2-a]pyridine
Purity: 95+%
Packaging: 5g
Price: $445
Updated: 2021/12/16

More

Less

8-METHYLIMIDAZO[1,2-A]PYRIDINE Chemical Properties,Usage,Production

Synthesis

1603-40-3

2032-35-1

874-10-2

General procedure for the synthesis of 8-methyl-imidazo[1,2-A]pyridine from 2-amino-3-methylpyridine and 2-bromo-1,1-diethoxyethane: 2-amino-3-methylpyridine (10 g, 92.5 mmol) and 2-bromo-1,1-diethoxyethane (36.4 g, 185 mmol) were dissolved in ethanol (100 mL). Subsequently, 48% aqueous hydrogen bromide solution (9 mL) was slowly added dropwise to the reaction solution. The reaction system was heated to 90 °C and after 26 h of reaction, the completion of the reaction was confirmed by LC-MS and then cooled to room temperature. The reaction system was first distilled under reduced pressure to remove ethanol, followed by neutralization of excess hydrobromic acid in the reaction with excess saturated aqueous sodium bicarbonate solution (100 mL) and solid sodium bicarbonate (15 g). The remaining mixture was extracted with ethyl acetate (200 mL x 3). All organic phases were combined, washed sequentially with deionized water (100 mL) and saturated brine (100 mL) each, dried with anhydrous sodium sulfate, and the solvent was subsequently removed by rotary evaporation. Finally, the remaining mixture was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 0-10%) to afford 8-methyl-imidazo[1,2-a]pyridine (12 g, 98% yield).

References

[1] Patent: CN106279160, 2017, A. Location in patent: Paragraph 0259; 0263; 0264; 0265
[2] Bulletin of the Chemical Society of Japan, 1999, vol. 72, # 6, p. 1327 - 1334

8-METHYLIMIDAZO[1,2-A]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

8-METHYLIMIDAZO[1,2-A]PYRIDINE Suppliers

China 58 Germany 1 Hungary 1 India 2 United Kingdom 2 United States 7 Global 71

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

SuZhou ShiYa Biopharmaceuticals, Inc.

Tel: 86(512)5235 8471 17715136450
Fax: 86(512)5235 6881
Email: sales@shiyabiopharm.com
Country: China
ProdList: 4169
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai RenYue Chemical Technology Co., Ltd.

Tel: 021-62219190; 18321139117
Email: 316441092@qq.com
Country: China
ProdList: 2905
Advantage: 55

Yancheng KangdiSen Pharmaceutical Co., Ltd.

Tel: 13812573443
Fax: -
Email: tongbenwan22@163.com
Country: China
ProdList: 1980
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 021-20242659 18930833303
Fax: +86 (21) 2024-2659
Email: Sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

874-10-2, 8-METHYLIMIDAZO[1,2-A]PYRIDINERelated Search:

8-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER Imidazo[1,2-a]pyridine-2-carboxaldehyde, 8-methyl- (9CI) 8-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID 2-AMINO-6-METHYLDIPYRIDO[1,2-A:3',2'-D]IMIDAZOLE, HYDROCHLORIDE MONOHYDRATE Ethyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate ,97% 3-nitro-5-methylimidazo[1,2-a]pyridine 2-Methylimidazo[1,2-a]pyridine-3-carboxylic acid ,97% (2,8-DIMETHYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-METHANOL 2,7-DIMETHYLPYRIDO[1,6-A]-1H-IMIDAZOLE-3-CARBOXYLIC ACID, ETHYL ESTER 2-Chloromethyl-8-methyl-imidazo[1,2-a]pyridine 7-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL 8-METHYL-2-PHENYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLATE 2-(4-FLUOROPHENYL)-8-METHYLIMIDAZO[1,2-A]PYRIDINE 2-(2-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine-3-carbaldehyde 2-(2,5-DIMETHYLPHENYL)-8-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE 2-(2-methoxyphenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde 2-(4-ethylphenyl)-6-methylimidazo[1,2-a]pyridine-3-carbaldehyde 2-(2,5-dimethylphenyl)-7-methylimidazo[1,2-a]pyridine-3-carbaldehyde

8-METHYLIMIDAZO[1,2-A]PYRIDINE

Imidazo[1,2-a]pyridine, 8-methyl-

8-methyl-imidazolopyrimidine

874-10-2