2-((tert-Butyldiphenylsilyl)oxy)acetic acid

Product Name: 2-((tert-Butyldiphenylsilyl)oxy)acetic acid
CAS No.: 76271-74-4
Chemical Name: 2-((tert-Butyldiphenylsilyl)oxy)acetic acid
Synonyms: DKFELEX0341;2-((tert-Butyldiphenylsilyl)oxy);2-((tert-Butyldiphenylsilyl)oxy)acetic acid;Acetic acid, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-
CBNumber: CB52693193
Molecular Formula: C18H22O3Si
Formula Weight: 314.45
MOL File: 76271-74-4.mol

More

Less

2-((tert-Butyldiphenylsilyl)oxy)acetic acid Property

Boiling point:: 395.1±34.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.41±0.10(Predicted)
Appearance: Colorless to light yellow Oil

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Matrix Scientific

Product number: 095009
Product name: 2-((tert-Butyldiphenylsilyl)oxy)acetic acid
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

AK Scientific

Product number: 1864AC
Product name: 2-((tert-Butyldiphenylsilyl)oxy)aceticacid
Packaging: 1g
Price: $978
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: ORS0003978
Product name: 2-((TERT-BUTYLDIPHENYLSILYL)OXY)ACETIC ACID
Purity: 95.00%
Packaging: 250MG
Price: $1218
Updated: 2021/12/16

Matrix Scientific

Product number: 095009
Product name: 2-((tert-Butyldiphenylsilyl)oxy)acetic acid
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: ORS0003978
Product name: 2-((TERT-BUTYLDIPHENYLSILYL)OXY)ACETIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $497.5
Updated: 2021/12/16

More

Less

2-((tert-Butyldiphenylsilyl)oxy)acetic acid Chemical Properties,Usage,Production

Uses

2-[(tert-Butyldiphenylsilyl)oxy]acetic Acid is an intermediate in the synthesis of N-Desmethyl-N-hydroxymethyl Tebuthiuron (D295445), a metabolite of the nonselective broad spectrum herbicide Tebuthiuron (T013620).

Synthesis

154698-92-7

76271-74-4

The general procedure for the synthesis of 2-((tert-butyldiphenylsilyl)oxy)acetic acid from methyl 2-((tert-butyldiphenylmethylsilyl)oxy)acetic acid was as follows: to a solution of methyl 2-((tert-butyldiphenylsilyl)oxy)acetic acid (8.86 g, 27.0 mmol) in THF/H2O (4:1, 33 mL) was added an aqueous 0.75 M LiOH solution ( 97 mL, 72.9 mmol). The reaction mixture was stirred at room temperature until thin layer chromatography (TLC) showed complete consumption of the feedstock. Upon completion of the reaction, water (appropriate amount) was added and the resulting mixture was extracted with ether (3 x 40 mL) to remove non-acidic impurities. The aqueous phase was acidified to pH 3 with 10% aqueous HCl and subsequently extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, dried with anhydrous MgSO4, filtered and concentrated under reduced pressure to give the crude product. The crude product was confirmed for purity by nuclear magnetic resonance (NMR), which resulted in 2-((tert-butyldiphenylmethylsilyl)oxy)acetic acid (7.97 g, 94% yield) as a colorless oil. The structure of the product was determined by 1H NMR (400 MHz, CDCl3): δ 7.68-7.65 (m, 4H), 7.46-7.38 (m, 6H), 4.25 (s, 2H), 1.10 (s, 9H); 13C NMR (100 MHz, CDCl3): δ 174.9,135.5,132.9,130.2. 128.0,61.9,26.7,19.2; mass spectrum (M/z): 237.1 (M+-Ph); Fourier Transform Infrared Spectroscopy (FT-IR, thin film): 1737 cm-1 (C=O telescoping vibration); Calculated values for elemental analysis (%): C, 68.75; H, 7.05; Measured values (%): C, 68.70; H, 6.91.

References

[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 3, p. 1236 - 1241
[2] Journal of the American Chemical Society, 2010, vol. 132, # 31, p. 10920 - 10934

2-((tert-Butyldiphenylsilyl)oxy)acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-((tert-Butyldiphenylsilyl)oxy)acetic acid Suppliers

China 40 India 1 United States 5 Global 46

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Haimen Ruiyi Medical Tech Co., LTD

Tel: 021-54718086
Fax: 021-54711707
Email: sales5@ruiyitech.com
Country: China
ProdList: 271
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai Chuen Pharmaceutical Technology Co., Ltd.

Tel: 18817486326 18817486326;
Email: 3237528851@qq.com
Country: China
ProdList: 51
Advantage: 58

Alfa Chemistry

Tel: +1-5166625404;
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 20405
Advantage: 58

Labnetwork lnc.

Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Country: China
ProdList: 19987
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9989
Advantage: 58

76271-74-4, 2-((tert-Butyldiphenylsilyl)oxy)acetic acidRelated Search:

Phosphorus oxitrichloride tert-Butyl methyl ether

2-((tert-Butyldiphenylsilyl)oxy)acetic acid

Acetic acid, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-

2-((tert-Butyldiphenylsilyl)oxy)

DKFELEX0341

76271-74-4