ChemicalBook > CAS DataBase List > Elobixibat
Elobixibat
- Product Name
- Elobixibat
- CAS No.
- 439087-18-0
- Chemical Name
- Elobixibat
- Synonyms
- A 3309;AZD-7806;AJG-533);Elosibat;Elobixibat;Elobixibat (G);Elobixibathydrate;Elobixibat In-House;Elobixibat (A-3309;Elobixibat (AZD-7806)
- CBNumber
- CB52694327
- Molecular Formula
- C36H45N3O7S2
- Formula Weight
- 695.89
- MOL File
- 439087-18-0.mol
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Elobixibat Property
- Boiling point:
- 969.6±65.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 3.20±0.10(Predicted)
- color
- White to off-white
- InChIKey
- XFLQIRAKKLNXRQ-UUWRZZSWSA-N
- SMILES
- C(O)(=O)CNC(=O)[C@@H](C1=CC=CC=C1)NC(COC1C=C2S(=O)(=O)CC(CCCC)(CCCC)CN(C3=CC=CC=C3)C2=CC=1SC)=O
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N-Bromosuccinimide Price
TRC
- Product number
- E505200
- Product name
- Elobixibat
- Packaging
- 150mg
- Price
- $15490
- Updated
- 2021/12/16
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Elobixibat Chemical Properties,Usage,Production
Uses
Elobixibat, is an ileal sodium-dependent bile acid transporter ( IBAT) inhibitor, used for the treatment of chronic constipation and irritable bowel syndrome with constipation (IBS-C).
in vivo
Elobixibat (0.27 mg/kg/day for 20 weeks, p.o.) inhibits tumor growth in the mouse model of fatty liver disease by inhibiting bile acid reabsorption and reducing total and primary bile acid levels in serum and liver[2].
Elobixibat (5 days a week for 4 weeks, 0.2, 0.6, or 1.2 mg/kg/day, gavage) improves NASH-related histopathology, reduces cytokine (TNF-α, IL-6, and TGF-β) expression, and normalizes gut microbiome composition in nonsteatohepatitis (NASH) mouse models[3].
| Animal Model: | Mouse Model of Nonalcoholic Steatohepatitis (three-week-old male C57BL/6J mice)[2] |
| Dosage: | 0.27 mg/kg/day for 20 weeks |
| Administration: | p.o. |
| Result: | Reduced the number and size of tumors. Significantly reduced the number of Gram-positive bacteria in the phyla Firmicutes, Deferobacteria and Actinobacteria and increased the number of Proteobacteria. |
IC 50
IBAT: 0.53 nM (IC50); IL-6; TNF-α; TNF-β
Elobixibat Preparation Products And Raw materials
Raw materials
Preparation Products
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Elobixibat Suppliers
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
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- 58
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- 18210857532; 18210857532
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- 86-10-82849933
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- China
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- 025-83697070
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- +86-25-83453306
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- China
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- 021-33632979
- Fax
- 021-34692979
- info@tsbiochem.com
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- China
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- -
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- China
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- 028-67271278 18628360895
- Fax
- 0575-89298961
- sales@artisbio.com
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- China
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- 571-89925085
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- 0086-571-89925065
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- China
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- 027-027-83778875 15807197853
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- China
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- +86 (21) 5775-8967
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- China
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- 028-85255396 18302801538
- Fax
- 028-85255396
- cdnovell@163.com
- Country
- China
- ProdList
- 2389
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View Lastest Price from Elobixibat manufacturers
Hangzhou ICH Biofarm Co., Ltd
- Product
- Elobixibat 439087-18-0
- Price
- US $12000.00/g
- Min. Order
- 1g
- Purity
- 99.0%min， single impurity：0.1%min
- Supply Ability
- 50kg
- Release date
- 2023-06-09
Senova Technology Co. Ltd.
- Product
- Elobixibat 439087-18-0
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2022-12-21