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Elobixibat

Product Name
Elobixibat
CAS No.
439087-18-0
Chemical Name
Elobixibat
Synonyms
A 3309;AZD-7806;AJG-533);Elosibat;Elobixibat;Elobixibat (G);Elobixibathydrate;Elobixibat In-House;Elobixibat (A-3309;Elobixibat (AZD-7806)
CBNumber
CB52694327
Molecular Formula
C36H45N3O7S2
Formula Weight
695.89
MOL File
439087-18-0.mol
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Elobixibat Property

Boiling point:
969.6±65.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
3.20±0.10(Predicted)
color 
White to off-white
InChIKey
XFLQIRAKKLNXRQ-UUWRZZSWSA-N
SMILES
C(O)(=O)CNC(=O)[C@@H](C1=CC=CC=C1)NC(COC1C=C2S(=O)(=O)CC(CCCC)(CCCC)CN(C3=CC=CC=C3)C2=CC=1SC)=O
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E505200
Product name
Elobixibat
Packaging
150mg
Price
$15490
Updated
2021/12/16
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Elobixibat Chemical Properties,Usage,Production

Uses

Elobixibat, is an ileal sodium-dependent bile acid transporter ( IBAT) inhibitor, used for the treatment of chronic constipation and irritable bowel syndrome with constipation (IBS-C).

in vivo

Elobixibat (0.27 mg/kg/day for 20 weeks, p.o.) inhibits tumor growth in the mouse model of fatty liver disease by inhibiting bile acid reabsorption and reducing total and primary bile acid levels in serum and liver[2].
Elobixibat (5 days a week for 4 weeks, 0.2, 0.6, or 1.2 mg/kg/day, gavage) improves NASH-related histopathology, reduces cytokine (TNF-α, IL-6, and TGF-β) expression, and normalizes gut microbiome composition in nonsteatohepatitis (NASH) mouse models[3].

Animal Model:Mouse Model of Nonalcoholic Steatohepatitis (three-week-old male C57BL/6J mice)[2]
Dosage:0.27 mg/kg/day for 20 weeks
Administration:p.o.
Result:Reduced the number and size of tumors.
Significantly reduced the number of Gram-positive bacteria in the phyla Firmicutes, Deferobacteria and Actinobacteria and increased the number of Proteobacteria.

IC 50

IBAT: 0.53 nM (IC50); IL-6; TNF-α; TNF-β

Elobixibat Preparation Products And Raw materials

Raw materials

Preparation Products

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Elobixibat Suppliers

China 61 India 7 United States 3 Global 71
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
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View Lastest Price from Elobixibat manufacturers

Hangzhou ICH Biofarm Co., Ltd
Product
Elobixibat 439087-18-0
Price
US $12000.00/g
Min. Order
1g
Purity
99.0%min， single impurity：0.1%min
Supply Ability
50kg
Release date
2023-06-09
Senova Technology Co. Ltd.
Product
Elobixibat 439087-18-0
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
10KG
Release date
2022-12-21

439087-18-0, ElobixibatRelated Search:


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  • Elobixibat (AZD-7806)
  • XFLQIRAKKLNXRQ-UUWRZZSWSA-N
  • AJG-533)
  • AZD-7806
  • Elobixibat (A-3309
  • A 3309
  • Glycine, (2R)-N-[2-[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,5-benzothiazepin-8-yl]oxy]acetyl]-2-phenylglycyl-
  • Elobixibathydrate
  • Elobixibat In-House
  • Elobixibat, >98% (HPLC)
  • Elosibat
  • Elobixibat (G)
  • (R)-2-(2-(2-((3,3-Dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-8-yl)oxy)acetamido)-2-phenylacetamido)acetic acid
  • 439087-18-0
  • 439087-16-0
  • C36H45N3O7S2
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals