(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine
- Product Name
- (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine
- CAS No.
- 1371569-69-5
- Chemical Name
- (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine
- Synonyms
- BETP;BETP, 10 mM in DMSO;Glucagon-Like Peptide 1 Receptor Agonist II;Glucagon Receptor,BETP,inhibit,GCGR,Inhibitor;(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine;2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-pyrimidine;Pyrimidine, 2-(ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)-
- CBNumber
- CB52694529
- Molecular Formula
- C20H17F3N2O2S
- Formula Weight
- 406.42
- MOL File
- 1371569-69-5.mol
(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Property
- Boiling point:
- 569.5±60.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- -5.23±0.50(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0558
- Product name
- BETP
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $150
- Updated
- 2025/07/31
- Product number
- SML0558
- Product name
- BETP
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $573
- Updated
- 2025/07/31
- Product number
- 346007
- Product name
- Glucagon-Like Peptide 1 Receptor Agonist II
- Packaging
- 10 mg
- Price
- $231
- Updated
- 2025/07/31
- Product number
- 4778
- Product name
- BETP
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $203
- Updated
- 2021/12/16
- Product number
- 4778
- Product name
- BETP
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $836
- Updated
- 2021/12/16
(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Chemical Properties,Usage,Production
Uses
(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoromethyl)pyrimidine acts as an allosteric modulator of the GLP-1 (glucagon-like peptide-1) receptor in preparation of orally therapeutic agents for the treatment of diabetes mellitus.
Biological Activity
BETP is a positive allosteric modulator of the GLP-1 receptor th at potentiates cAMP accumulation and glucose-dependent insulin release in pancreatic islet cells, in the presence of the weak GLP-1 metabolite, GLP-1(9-36). BETP has additive effects on the endogenous GLP-1 receptor ligand GLP-1(7-36).', 'BetP is a trimeric Na+-coupled betaine symporter. BetP belongs to the betaine-choline-carnitine transporter (BCCT) family. It controls transport activity in dependence of the cytoplasmic K+-concentration.
in vivo
BETP has insulinotropic effect in SD rats. BETP (10 mg/kg, jugular vein cannula) exhibits insulin secretagogue activity in the intravenous glucose tolerance test (IVGTT) model. BETP (10 mg/kg, i.v.)-treated rats need 20% higher glucose infusion rates and demonstrates higher plasma insulin levels in SD rat hyperglycemic clamp model[1]. BETP (5 mg/kg) enhances oxyntomodulin-stimulated insulin secretion[2].
storage
Store at +4°C
(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Preparation Products And Raw materials
Raw materials
Preparation Products
(4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine Suppliers
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View Lastest Price from (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine manufacturers
- Product
- (4-(3-Benzyloxyphenyl)-2-ethylsulfinyl-6-(trifluoroMethyl)pyriMidine 1371569-69-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31