N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide
- Product Name
- N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide
- CAS No.
- 927822-86-4
- Chemical Name
- N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide
- Synonyms
- KC7F2;KC7F2, >98%;HIF-1α Translation Inhibitor, KC7F2;N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide;HIF-1α Translation Inhibitor, KC7F2 - CAS 927822-86-4 - Calbiochem;Benzenesulfonamide, N,N'-(dithiodi-2,1-ethanediyl)bis[2,5-dichloro-;N,N'-(Disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide);N,N'-(Disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide);N,N'-(2,2'-disulfanediylbis(ethane-2,1-diyl))bis(2,5-dichlorobenzenesulfonamide);2,5-dichloro-N-[2-[2-[(2,5-dichlorophenyl)sulfonylamino]ethyldisulfanyl]ethyl]benzenesulfonamide
- CBNumber
- CB52696033
- Molecular Formula
- C16H16Cl4N2O4S4
- Formula Weight
- 570.38
- MOL File
- 927822-86-4.mol
N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Property
- Boiling point:
- 708.8±70.0 °C(Predicted)
- Density
- 1.583±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 9.26±0.50(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- SML1043
- Product name
- KC7F2
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $46.5
- Updated
- 2024/03/01
- Product number
- 400088
- Product name
- HIF-1α Translation Inhibitor, KC7F2
- Packaging
- 25mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 14123
- Product name
- KC7F2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 14123
- Product name
- KC7F2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- SML1043
- Product name
- KC7F2
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $76.7
- Updated
- 2024/03/01
N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Chemical Properties,Usage,Production
Description
KC7F2 (927822-86-4) is an inhibitor of HIF-1α (IC50 = 20 μM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of HIF-1α protein synthesis accompanied by suppression of phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 and p70 S6 kinase, key regulators of HIF-1α protein synthesis.
Uses
N,N''-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide is a hypoxia inducible factor (HIF-1) inhibitor which act via down regulation of HIF-1α synthesis.
Uses
N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonamide is a hypoxia inducible factor (HIF-1) inhibitor which act via down regulation of HIF-1α synthesis.
storage
Store at -20°C
References
1)Narita et al. (2009), Identification of a Novel Small Molecule HIF-1α Translation Inhibitor; Clin. Cancer Res. 15 6128
N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide manufacturers
- Product
- N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichloro-benzenesulfonaMide 927822-86-4
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20