2-Amino-4-bromo-3-fluorobenzoic acid
- Product Name
- 2-Amino-4-bromo-3-fluorobenzoic acid
- CAS No.
- 1416013-62-1
- Chemical Name
- 2-Amino-4-bromo-3-fluorobenzoic acid
- Synonyms
- 140622;Ethanol,5-diazenyl-;Oxymetazoline Impurity 10;3-BROMO-6-CARBOXY-2-FLUOROANILINE;2-amino-4-bromo-3-fluorobenzoicaci;2-Amino-3-fluoro-4-bromobenzoic acid;2-Amino-4-bromo-3-fluorobenzoic acid;Benzoic acid, 2-amino-4-bromo-3-fluoro-
- CBNumber
- CB52697454
- Molecular Formula
- C7H5BrFNO2
- Formula Weight
- 234.02
- MOL File
- 1416013-62-1.mol
2-Amino-4-bromo-3-fluorobenzoic acid Property
- Boiling point:
- 332.0±42.0 °C(Predicted)
- Density
- 1.877±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.37±0.10(Predicted)
- form
- powder
- color
- Off white
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A577113
- Product name
- 2-Amino-4-Bromo-3-FluorobenzoicAcid
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC500189
- Product name
- 2-Amino-4-bromo-3-fluorobenzoicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $67
- Updated
- 2021/12/16
- Product number
- 4657-B-00
- Product name
- 2-Amino-4-bromo-3-fluorobenzoic acid
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- Y1761
- Product name
- 2-Amino-4-bromo-3-fluorobenzoicacid
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- PC500189
- Product name
- 2-Amino-4-bromo-3-fluorobenzoicacid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $37
- Updated
- 2021/12/16
2-Amino-4-bromo-3-fluorobenzoic acid Chemical Properties,Usage,Production
Description
2-Amino-4-bromo-3-fluorobenzoic acid is an important pharmaceutical and organic intermediate ingredient used in the synthesis of avibactam sodium, an FDA-approved non-beta-lactam β-lactamase inhibitor used in combination with ceftazidime (Avycaz). It is used for the treatment of complicated intra-abdominal infections, urinary tract infections, and pyelonephritis.
Uses
2-Amino-4-Bromo-3-Fluorobenzoic Acid is used in preparation of Quinazoline compounds as KRAS modulators and antitumor agents.
Synthesis
The synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid is as follows:
To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).
2-Amino-4-bromo-3-fluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-4-bromo-3-fluorobenzoic acid manufacturers
- Product
- 2-Amino-4-bromo-3-fluorobenzoic acid 1416013-62-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31