2,6-difluoro-3,5-diMethoxybenzenaMine
- Product Name
- 2,6-difluoro-3,5-diMethoxybenzenaMine
- CAS No.
- 651734-54-2
- Chemical Name
- 2,6-difluoro-3,5-diMethoxybenzenaMine
- Synonyms
- 2,6-Difluoro-3,5-dimethoxyaniline;PEMIGATINIB INT1;Pemetinib intermediate;Chlorpyrifos Impurity 8 (Profenofos);2,6-difluoro-3,5-diMethoxybenzenaMine;2,6-difluoro-3,5-dimethoxy-phenylamine;2,6-difluoro-3,5-dimethoxybenzeneamine;Benzenamine, 2,6-difluoro-3,5-dimethoxy-
- CBNumber
- CB52702895
- Molecular Formula
- C8H9F2NO2
- Formula Weight
- 189.16
- MOL File
- 651734-54-2.mol
2,6-difluoro-3,5-diMethoxybenzenaMine Property
- Boiling point:
- 301.0±37.0 °C(Predicted)
- Density
- 1.276±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.97±0.10(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C8H9F2NO2/c1-12-4-3-5(13-2)7(10)8(11)6(4)9/h3H,11H2,1-2H3
- InChIKey
- SUXITUVUFUOAGT-UHFFFAOYSA-N
- SMILES
- C1(N)=C(F)C(OC)=CC(OC)=C1F
Safety
- HS Code
- 2922190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D554150
- Product name
- 2,6-Difluoro-3,5-dimethoxyaniline
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- D554150
- Product name
- 2,6-Difluoro-3,5-dimethoxyaniline
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- PC908567
- Product name
- 2,6-Difluoro-3,5-dimethoxyaniline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 4805AQ
- Product name
- 2,6-difluoro-3,5-dimethoxyaniline
- Packaging
- 250mg
- Price
- $180.8
- Updated
- 2021/12/16
- Product number
- 4805AQ
- Product name
- 2,6-difluoro-3,5-dimethoxyaniline
- Packaging
- 1g
- Price
- $380
- Updated
- 2021/12/16
2,6-difluoro-3,5-diMethoxybenzenaMine Chemical Properties,Usage,Production
Uses
2,6-Difluoro-3,5-dimethoxyaniline is an organic compound used primarily as an organic synthesis intermediate and a pharmaceutical intermediate, especially in laboratory research and development and chemical production processes. The compound is a key intermediate in the drug pemigatinib, used to treat certain types of cancer.
Synthesis
651734-57-5
651734-54-2
Tert-butyl 2,6-difluoro-3,5-dimethoxyphenylcarbamate (34.6 g, 0.12 mol) was added to 120 mL of trifluoroacetic acid and stirred until completely dissolved to form a homogeneous solution. The reaction mixture was stirred at room temperature for 30 minutes. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, saturated sodium bicarbonate solution was slowly added to adjust the pH to 8. The resulting suspension was extracted twice with diethyl ether (appropriate amount each time). The organic phases were combined, washed once with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 22 g of 2,6-difluoro-3,5-dimethoxyaniline in 97% yield. The mass spectrum (APCI) showed (M+1)/z of 190.1.
References
[1] Patent: WO2006/38112, 2006, A1. Location in patent: Page/Page column 28
[2] Patent: US2004/19210, 2004, A1. Location in patent: Page 13
2,6-difluoro-3,5-diMethoxybenzenaMine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-difluoro-3,5-diMethoxybenzenaMine manufacturers
- Product
- 2,6-Difluoro-3,5-dimethoxybenzenamine 651734-54-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-29