ChemicalBook > CAS DataBase List > AZD-5069

AZD-5069

Product Name
AZD-5069
CAS No.
878385-84-3
Chemical Name
AZD-5069
Synonyms
CS-2808;AZD-5069;CPDD1543;ACT-281959;AZD 5069; AZD5069;AZD-5069, 10 mM in DMSO;AZD-5069; AZD 5069; AZD5069;878385-84-3;inhibit,CXCR,Inhibitor,AZD-5069,AZD5069,AZD 5069,CXC chemokine receptors;N-[2-[(2,3-Difluorobenzyl)thio]-6-[[(2R,3S)-3,4-dihydroxy-2-butyl]oxy]-4-pyrimidinyl]azetidine-1-sulfonamide;N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
CBNumber
CB52702941
Molecular Formula
C18H22F2N4O5S2
Formula Weight
476.52
MOL File
878385-84-3.mol
More
Less

AZD-5069 Property

Melting point:
149-152°C
Boiling point:
680.5±65.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.56±0.20(Predicted)
form 
Solid
color 
White to Off-White
More
Less

Safety

HS Code 
2935909099
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28297
Product name
AZD 5069
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
28297
Product name
AZD 5069
Packaging
25mg
Price
$515
Updated
2024/03/01
Cayman Chemical
Product number
28297
Product name
AZD 5069
Packaging
5mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
28297
Product name
AZD 5069
Packaging
10mg
Price
$238
Updated
2024/03/01
TRC
Product number
A965309
Product name
AZD-5069
Packaging
5mg
Price
$130
Updated
2021/12/16
More
Less

AZD-5069 Chemical Properties,Usage,Production

Description

AZD5069 is a potent, selective reversible (time and temperature dependent) antagonist of the human CXCR2 receptor that used for caner treatment.

Uses

AZD-5069 is a potent and selective CXCR2 antagonist with potential as a therapeutic agent in inflammatory conditions.

Biological Activity

AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2; IC50 = 0.79 nM in a radioligand binding assay). It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 μmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation.

IC 50

125I-IL-8-CXCR2

AZD-5069 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AZD-5069 Suppliers

China 72 United States 9 Global 81
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai XingMo Biotechnology Co., Ltd.
Tel
+86 13524779951; 13524779951
Fax
QQ: 2075692521
Email
2075692521@qq.com
Country
China
ProdList
310
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Twochem Co.Ltd
Tel
021-021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
304
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
7218
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68

878385-84-3, AZD-5069Related Search:


  • AZD-5069
  • ACT-281959
  • CPDD1543
  • AZD 5069; AZD5069
  • CS-2808
  • AZD-5069; AZD 5069; AZD5069;878385-84-3
  • N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
  • 1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-
  • N-(2-(((2,3-Difluorophenyl)methyl)thio)-6-(((1R,2S)-2,3-dihydroxy-1-methylpropyl)oxy)-4-pyrimidinyl)-1-azetidinesulfonamide
  • inhibit,CXCR,Inhibitor,AZD-5069,AZD5069,AZD 5069,CXC chemokine receptors
  • AZD-5069, 10 mM in DMSO
  • N-[2-[(2,3-Difluorobenzyl)thio]-6-[[(2R,3S)-3,4-dihydroxy-2-butyl]oxy]-4-pyrimidinyl]azetidine-1-sulfonamide
  • 878385-84-3
  • C18H22F2N4O5S2
  • APIs