AZD-5069
- Product Name
- AZD-5069
- CAS No.
- 878385-84-3
- Chemical Name
- AZD-5069
- Synonyms
- CS-2808;AZD-5069;CPDD1543;ACT-281959;AZD 5069; AZD5069;AZD-5069; AZD 5069; AZD5069;878385-84-3;inhibit,CXCR,Inhibitor,AZD-5069,AZD5069,AZD 5069,CXC chemokine receptors;N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide;1-Azetidinesulfonamide, N-[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R,2S)-2,3-dihydroxy-1-methylpropoxy]-4-pyrimidinyl]-;N-(2-(((2,3-Difluorophenyl)methyl)thio)-6-(((1R,2S)-2,3-dihydroxy-1-methylpropyl)oxy)-4-pyrimidinyl)-1-azetidinesulfonamide
- CBNumber
- CB52702941
- Molecular Formula
- C18H22F2N4O5S2
- Formula Weight
- 476.52
- MOL File
- 878385-84-3.mol
AZD-5069 Property
- Melting point:
- 149-152°C
- Boiling point:
- 680.5±65.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 4.56±0.20(Predicted)
- form
- Solid
- color
- White to Off-White
Safety
- HS Code
- 2935909099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 28297
- Product name
- AZD 5069
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 28297
- Product name
- AZD 5069
- Packaging
- 25mg
- Price
- $515
- Updated
- 2024/03/01
- Product number
- 28297
- Product name
- AZD 5069
- Packaging
- 5mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 28297
- Product name
- AZD 5069
- Packaging
- 10mg
- Price
- $238
- Updated
- 2024/03/01
- Product number
- A965309
- Product name
- AZD-5069
- Packaging
- 5mg
- Price
- $130
- Updated
- 2021/12/16
AZD-5069 Chemical Properties,Usage,Production
Description
AZD5069 is a potent, selective reversible (time and temperature dependent) antagonist of the human CXCR2 receptor that used for caner treatment.
Uses
AZD-5069 is a potent and selective CXCR2 antagonist with potential as a therapeutic agent in inflammatory conditions.
Biological Activity
AZD 5069 is an antagonist of chemokine receptor 2 (CXCR2; IC50 = 0.79 nM in a radioligand binding assay). It inhibits CXCL1-induced CD11b expression in and chemotaxis of isolated human neutrophils (pA2s = 6.9 and 9.1, respectively). AZD 5069 (3 and 10 μmol/kg) inhibits bronchoalveolar lavage fluid (BALF) neutrophil influx in a rat model of LPS-induced lung neutrophilia and non-allergic airway inflammation.
AZD-5069 Preparation Products And Raw materials
Raw materials
Preparation Products
AZD-5069 Suppliers
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