tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate

Product Name: tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
CAS No.: 1121057-77-9
Chemical Name: tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Synonyms: N-boc-3,4-dihydropiperidine-5-boronic acid pinacol ester;1-Boc-1,4,5,6-tetrahydropyridine-3-boronic Acid Pinacol Ester;tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-t...;tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dih;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1;(1-(TERT-BUTOXYCARBONYL)-1,4,5,6-TETRAHYDROPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate;tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxyla;ert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2, 3,4-tetrahydropyridine-1-carboxylate
CBNumber: CB52704819
Molecular Formula: C16H28BNO4
Formula Weight: 309.21
MOL File: 1121057-77-9.mol

More

Less

tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Property

Boiling point:: 339.6±52.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: -0.31±0.40(Predicted)
Appearance: White to off-white Solid

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B710065
Product name: tert-Butyl5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Packaging: 50mg
Price: $155
Updated: 2021/12/16

Synthonix

Product number: T10684
Product name: tert-butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Purity: 97.0%
Packaging: 500mg
Price: $390
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0025794
Product name: TERT-BUTYL-5-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,4-TETRAHYDROPYRIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $452.65
Updated: 2021/12/16

Apolloscientific

Product number: OR55284
Product name: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2h)-carboxylate
Packaging: 500mg
Price: $844
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H60-1-KC
Product name: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Packaging: 500mg
Price: $1000
Updated: 2021/12/16

More

Less

tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Chemical Properties,Usage,Production

Synthesis

149108-74-7

73183-34-3

1121057-77-9

Step 4. tert-Butyl 5-(((trifluoromethyl)sulfonyl)oxy)-3,4-dihydropyridine-1(2H)-carboxylate (1.45 g, 4.38 mmol) and pinacol ester of bisboronic acid (1.223 g, 4.81 mmol) were dissolved in dioxane (24 mL). To this solution was added potassium acetate (1.289 g, 13.13 mmol) and PdCl2(dppf)-CH2Cl2 adduct (0.107 g, 0.131 mmol). The reaction mixture was purged for 5 min under nitrogen protection and subsequently heated in an oil bath at 80 °C overnight. After completion of the reaction, the mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast chromatography using a 0-30% ethyl acetate/heptane gradient elution to afford the target product tert-butyl 5-boronic acid pinacol esteryl-3,4-dihydropyridine-1(2H)-carboxylate as a highly viscous liquid (1.2 g, 89% yield).LCMS (m/z): 254.1 (MH+ - tBu), retention time 1.21 min.

References

[1] Patent: US9242996, 2016, B2. Location in patent: Page/Page column 385; 386; 388; 389
[2] Patent: WO2018/203256, 2018, A1. Location in patent: Page/Page column 36
[3] Patent: US2013/102601, 2013, A1. Location in patent: Paragraph 184
[4] Patent: US2013/102600, 2013, A1. Location in patent: Page/Page column 0169; 0171
[5] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 44-45

tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Suppliers

China 68 India 1 United Kingdom 1 United States 6 Global 76

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Chengdu Aslee Biopharmaceuticals, Inc

Tel: 028-85305008 02885305008
Fax: 4000210878-186
Email: 2306208234@qq.com
Country: China
ProdList: 1006
Advantage: 50

DebyeTec.com Inc.

Tel: 18-086626237 18086626237
Fax: qq:2693528373
Email: 2693528373@qq.com
Country: China
ProdList: 2973
Advantage: 56

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Combiphos (Shanghai) Biological Technology Co., Ltd.

Tel: 021-65232103 17602124823
Email: combiphos@vip.qq.com
Country: China
ProdList: 30000
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Zhaoqing Wanwei New Material Technology Co., Ltd.

Tel: 0755-1328880-4488 13068786899
Fax: 13068786899
Email: 13288804488@163.com
Country: China
ProdList: 625
Advantage: 58

More

Less

View Lastest Price from tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate manufacturers

Career Henan Chemical Co

Product: tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate 1121057-77-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 100kg
Release date: 2020-01-07

1121057-77-9, tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylateRelated Search:

tert-Butyl 6-broMo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate tert-butyl 2-oxo-1,8-diazaspiro[4.5]decane-8-carboxylate Tert-Butyl7-oxo-3-azabicyclo[3.3.1]nonane-3-carboxylate tert-Butyl N-[(1-aMinocyclobutyl)Methyl]carbaMate tert-butyl (trans-3-aMino-3-Methylcyclobutyl)carbaMate 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyrimidine Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxyla

N-boc-3,4-dihydropiperidine-5-boronic acid pinacol ester

tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate

(1-(TERT-BUTOXYCARBONYL)-1,4,5,6-TETRAHYDROPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER

tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dih

1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester

tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-t...

tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2, 3,4-tetrahydropyridine-1-carboxylate

1-Boc-1,4,5,6-tetrahydropyridine-3-boronic Acid Pinacol Ester

5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

ert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate

tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate - [T10684]

1121057-77-9

Organic boronic acid