tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate

Product Name: tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
CAS No.: 1121057-77-9
Chemical Name: tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Synonyms: N-boc-3,4-dihydropiperidine-5-boronic acid pinacol ester;1-Boc-1,4,5,6-tetrahydropyridine-3-boronic Acid Pinacol Ester;tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-t...;tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dih;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1;(1-(TERT-BUTOXYCARBONYL)-1,4,5,6-TETRAHYDROPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate;tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxyla;ert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate;tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2, 3,4-tetrahydropyridine-1-carboxylate
CBNumber: CB52704819
Molecular Formula: C16H28BNO4
Formula Weight: 309.21
MOL File: 1121057-77-9.mol

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tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Property

Boiling point:: 339.6±52.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: -0.31±0.40(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: B710065
Product name: tert-Butyl5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Packaging: 50mg
Price: $155
Updated: 2021/12/16

Synthonix

Product number: T10684
Product name: tert-butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Purity: 97.0%
Packaging: 5g
Price: $1770
Updated: 2021/12/16

Synthonix

Product number: T10684
Product name: tert-butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Purity: 97.0%
Packaging: 10g
Price: $2950
Updated: 2021/12/16

Synthonix

Product number: T10684
Product name: tert-butyl5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Purity: 97.0%
Packaging: 500mg
Price: $390
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0025794
Product name: TERT-BUTYL-5-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,4-TETRAHYDROPYRIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $452.65
Updated: 2021/12/16

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tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Chemical Properties,Usage,Production

Synthesis

149108-74-7

73183-34-3

1121057-77-9

Step 4. tert-Butyl 5-(((trifluoromethyl)sulfonyl)oxy)-3,4-dihydropyridine-1(2H)-carboxylate (1.45 g, 4.38 mmol) and pinacol ester of bisboronic acid (1.223 g, 4.81 mmol) were dissolved in dioxane (24 mL). To this solution was added potassium acetate (1.289 g, 13.13 mmol) and PdCl2(dppf)-CH2Cl2 adduct (0.107 g, 0.131 mmol). The reaction mixture was purged for 5 min under nitrogen protection and subsequently heated in an oil bath at 80 °C overnight. After completion of the reaction, the mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast chromatography using a 0-30% ethyl acetate/heptane gradient elution to afford the target product tert-butyl 5-boronic acid pinacol esteryl-3,4-dihydropyridine-1(2H)-carboxylate as a highly viscous liquid (1.2 g, 89% yield).LCMS (m/z): 254.1 (MH+ - tBu), retention time 1.21 min.

References

[1] Patent: US9242996, 2016, B2. Location in patent: Page/Page column 385; 386; 388; 389
[2] Patent: WO2018/203256, 2018, A1. Location in patent: Page/Page column 36
[3] Patent: US2013/102601, 2013, A1. Location in patent: Paragraph 184
[4] Patent: US2013/102600, 2013, A1. Location in patent: Page/Page column 0169; 0171
[5] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 44-45

tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Suppliers

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View Lastest Price from tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate manufacturers

Career Henan Chemical Co

Product: tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate 1121057-77-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 100kg
Release date: 2020-01-07

1121057-77-9, tert-butyl 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylateRelated Search:

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tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxyla

N-boc-3,4-dihydropiperidine-5-boronic acid pinacol ester

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tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dih

1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester

tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-t...

tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2, 3,4-tetrahydropyridine-1-carboxylate

1-Boc-1,4,5,6-tetrahydropyridine-3-boronic Acid Pinacol Ester

5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

ert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate

tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate - [T10684]

1121057-77-9

Organic boronic acid