CDDO-EA
- Product Name
- CDDO-EA
- CAS No.
- 932730-51-3
- Chemical Name
- CDDO-EA
- Synonyms
- TP319;TP 319;RTA405;TP-319);CDDO-EA;RTA 405;RTA-405;CS-1305;CDDO ethyl amide;Bardoxolone ethyl amide
- CBNumber
- CB52705078
- Molecular Formula
- C33H46N2O3
- Formula Weight
- 518.73
- MOL File
- 932730-51-3.mol
CDDO-EA Property
- Boiling point:
- 670.7±55.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 34 mg/mL (65.54 mM)
- form
- Powder
- pka
- 16.21±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- orb611797
- Product name
- CDDO-EA
- Packaging
- 10mg
- Price
- $615.4
- Updated
- 2021/12/16
- Product number
- orb611797
- Product name
- CDDO-EA
- Packaging
- 50mg
- Price
- $1802
- Updated
- 2021/12/16
- Product number
- orb611797
- Product name
- CDDO-EA
- Packaging
- 100mg
- Price
- $2512.6
- Updated
- 2021/12/16
- Product number
- CD31000205
- Product name
- CDDO-EA
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $245
- Updated
- 2021/12/16
- Product number
- CD31000205
- Product name
- CDDO-EA
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
CDDO-EA Chemical Properties,Usage,Production
Biological Activity
CDDO-EA is a NF-E2-related factor 2/antioxidant response element (Nrf2/ARE) activator.
in vitro
CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. It is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS.
in vivo
The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%).
target
Nrf2/ARE
CDDO-EA Preparation Products And Raw materials
Raw materials
Preparation Products
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