ChemicalBook > CAS DataBase List > (3S,5R)-Rosuvastatin

(3S,5R)-Rosuvastatin

Product Name
(3S,5R)-Rosuvastatin
CAS No.
1242184-42-4
Chemical Name
(3S,5R)-Rosuvastatin
Synonyms
5R)-Rosuvastatin;(3S,5R)-Rosuvastatin;Rosuvastatin calcium-8;Rosuvastatin Impurity G;(3S,5R,6E)-Rosuvastatin;Rosuvastatin EP Impurity G;*Buprenorphine Impurity 17;Rosuvastatin impurity G CRS;Rosuvastatin Acid Enantiomer;Rosuvastatin EP Imp G (acid)
CBNumber
CB52706297
Molecular Formula
C22H28FN3O6S
Formula Weight
481.54
MOL File
1242184-42-4.mol
More
Less

(3S,5R)-Rosuvastatin Property

Boiling point:
745.6±70.0 °C(Predicted)
Density 
1.368±0.06 g/cm3(Predicted)
solubility 
soluble in Methanol, Water
pka
4.25±0.10(Predicted)
form 
Solid
color 
Off-White to Pale Yellow
Stability:
Hygroscopic
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0028000
Product name
ROSUVASTATIN RC D
Purity
95.00%
Packaging
5MG
Price
$450.2
Updated
2021/12/16
More
Less

(3S,5R)-Rosuvastatin Chemical Properties,Usage,Production

Description

Rosuvastatin is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.

Uses

(3S,5R,6E)-Rosuvastatin is an isomer of Rosuvastatin(R700500), an impurity which acts as a selective, competitive HMG-CoA reductase inhibitor.

Biological Activity

(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

(3S,5R)-Rosuvastatin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(3S,5R)-Rosuvastatin Suppliers

Canada 1 China 60 India 4 United States 7 Global 72
More
Less

View Lastest Price from (3S,5R)-Rosuvastatin manufacturers

Guangzhou PI PI BIOTECH INC
Product
Rosuvastatin Calcium Impurity G 1242184-42-4
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
90%+
Supply Ability
10g
Release date
2020-06-12

1242184-42-4, (3S,5R)-RosuvastatinRelated Search:

Rosuvastatin EP Impurity E (Calcium Salt) Pitavastatin Impurity 8 Rosuvastatin Impurity 14 (3R,5R)-Rosuvastatin N-DESMETHYL ROSUVASTATIN-D3 Rosuvastatin (3S,5R)-Rosuvastatin Methyl Ester Rosuvastatin IMpurity (5-Oxo Rosuvastatin tert-Butyl Ester) Rosuvastatin Anhydro Lactone Rosuvastatin IsoaMy Ester Rosuvastatin EP impurity A N-[4-(4-Fluorophenyl)-6-(1-methylethyl)-5-[(1E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methylmethanesulfonamide Rosuvastatin methyl ester tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol 3-Oxo Rosuvastatin SodiuM Salt Rosuvastatin ethyl ester Rosuvastatin EP impurity H

  • (3S,5R)-Rosuvastatin
  • (3s,5r,6e)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid
  • Rosuvastatin Calcium EP Impurity G (Calcium Salt)
  • Rosuvastatin EP impurity G(3S5R)
  • Rosuvastatin Impurity G
  • Rosuvastatin EP Imp G (acid)
  • Rosuvastatin calcium-8
  • 3S,5R-Rosuvastatin calcium salt
  • Rosuvastatin EP Impurity G
  • Rosuvastatin (3S,5R) Enantiomer (as diisopropylamine salt)
  • (3S,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid
  • Rosuvastatin EP Impurity G (Calcium Salt)
  • Rosuvastatin impurity G CRS
  • (3S,5R)-Rosuvastatin Sodium Salt
  • 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3S,5R,6E)-
  • Rosuvastatin (3S,5R) enantiomer
  • (3S,5R,6E)-Rosuvastatin
  • (3S,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid, calcium salt (2:1)
  • Rosuvastatin EP Impurity G/ Rosuvastatin Related Compund D (Rosuvastatin Calcium Enantiomer/ enti-Rosuvastatin/ Rosuvastatin (3S,5R)-Isomer)
  • Rosuvastatin impurity G (Y0001722)Q: What is Rosuvastatin impurity G (Y0001722) Q: What is the CAS Number of Rosuvastatin impurity G (Y0001722)
  • (3S,5R)-Rosuvastatin CalciumQ: What is (3S,5R)-Rosuvastatin Calcium Q: What is the CAS Number of (3S,5R)-Rosuvastatin Calcium Q: What is the storage condition of (3S,5R)-Rosuvastatin Calcium Q: What are the applications of (3S,5R)-Rosuvastatin Calcium
  • Rosuvastatin Acid Enantiomer
  • 5R)-Rosuvastatin
  • Rosuvastatin EP Impurity G / Rosuvastatin Related Compound D / 3S, 5R Rosuvastatin
  • (3S,5R) Rosuvastatin,(3S,5R)Rosuvastatin
  • ((3S,5R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethyl sulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate) calcium(II)（Rosuvastatin EP Impurity G）
  • Rosuvastatin Impurity 11 Monomer(Rosuvastatin EP Impurity G Monomer)
  • *Buprenorphine Impurity 17
  • (3S,5R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino]pyrimidin-5-yl]-3,5-dihydroxy-6(E)-heptenoic acid calcium salt
  • 1242184-42-4