ChemicalBook > CAS DataBase List > GSA 10

GSA 10

Product Name
GSA 10
CAS No.
300833-95-8
Chemical Name
GSA 10
Synonyms
GSA 10;propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate;Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate;4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester;Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester;Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell
CBNumber
CB52716245
Molecular Formula
C26H30N2O5
Formula Weight
450.53
MOL File
300833-95-8.mol
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GSA 10 Property

Boiling point:
620.2±55.0 °C(Predicted)
Density 
1.240±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble to 5 mM in DMSO with gentle warming
form 
Powder
pka
4.50±1.00(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16164
Product name
GSA 10
Purity
≥95%
Packaging
5mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
16164
Product name
GSA 10
Purity
≥95%
Packaging
10mg
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
16164
Product name
GSA 10
Purity
≥95%
Packaging
25mg
Price
$374
Updated
2024/03/01
Cayman Chemical
Product number
16164
Product name
GSA 10
Purity
≥95%
Packaging
50mg
Price
$702
Updated
2024/03/01
Tocris
Product number
4918
Product name
GSA10
Purity
≥98%(HPLC)
Packaging
50
Price
$771
Updated
2021/12/16
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GSA 10 Chemical Properties,Usage,Production

Description

Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.

Uses

GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine.

GSA 10 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSA 10 Suppliers

China 34 India 1 United Kingdom 3 United States 6 Global 44
Guangzhou Zhiya Chemdrugs Co.,Ltd
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300833-95-8, GSA 10Related Search:


  • Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
  • propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate
  • GSA 10
  • 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
  • Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell
  • Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester
  • 300833-95-8