GSA 10
- Product Name
- GSA 10
- CAS No.
- 300833-95-8
- Chemical Name
- GSA 10
- Synonyms
- GSA 10;propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate;Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate;4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester;Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester;Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell
- CBNumber
- CB52716245
- Molecular Formula
- C26H30N2O5
- Formula Weight
- 450.53
- MOL File
- 300833-95-8.mol
GSA 10 Property
- Boiling point:
- 620.2±55.0 °C(Predicted)
- Density
- 1.240±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble to 5 mM in DMSO with gentle warming
- form
- Powder
- pka
- 4.50±1.00(Predicted)
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16164
- Product name
- GSA 10
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 16164
- Product name
- GSA 10
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $158
- Updated
- 2024/03/01
- Product number
- 16164
- Product name
- GSA 10
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $374
- Updated
- 2024/03/01
- Product number
- 16164
- Product name
- GSA 10
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $702
- Updated
- 2024/03/01
- Product number
- 4918
- Product name
- GSA10
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $771
- Updated
- 2021/12/16
GSA 10 Chemical Properties,Usage,Production
Description
Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.
Uses
GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine.