Vonoprazan FuMarate

ChemicalBook > CAS DataBase List > Vonoprazan FuMarate

Product Name: Vonoprazan FuMarate
CAS No.: 881681-01-2
Chemical Name: Vonoprazan FuMarate
Synonyms: Vonoprazan Fumurate;5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate;Voranomazin;TAK-438,Takecab;TAK438 Fumarate;TAK 438 Fumarate;TAK-438 Fumarate;Fumarate vonorazan;Vonoprazan FuMarat;Vonorazan Fumarate
CBNumber: CB52716735
Molecular Formula: C21H20FN3O6S
Formula Weight: 461.46
MOL File: 881681-01-2.mol

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Vonoprazan FuMarate Property

storage temp.: Store at -20°C
solubility: DMSO: 50 mg/mL (108.35 mM)
form: Solid
color: White to Off-White
InChIKey: ROGSHYHKHPCCJW-WLHGVMLRSA-N
SMILES: C(/C(=O)O)=C\C(=O)O.S(C1=CN=CC=C1)(N1C=C(CNC)C=C1C1C=CC=CC=1F)(=O)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: V767013
Product name: VonoprazanFumarate
Packaging: 50mg
Price: $650
Updated: 2021/12/16

TRC

Product number: V767013
Product name: VonoprazanFumarate
Packaging: 5mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-0746
Product name: Vonoprazan(Fumarate)
Purity: 99.94%
Packaging: 250mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0746
Product name: Vonoprazan(Fumarate)
Purity: 99.94%
Packaging: 500mg
Price: $170
Updated: 2021/12/16

Axon Medchem

Product number: Axon1971
Product name: TAK438
Purity: 98%
Packaging: 25mg
Price: $533.5
Updated: 2021/12/16

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Vonoprazan FuMarate Chemical Properties,Usage,Production

Chemical Properties

Vonoprazan fumarate is white to nearly white crystals or crystalline powder which melts at 194.8°C . It can be dissolved in dimethyl sulfoxide, but has limited solubility in N,N-dimethylacetamide, N,N-dimethylformamide, methanol, and water. It is only slightly soluble in ethanol (99.5%), and has very low solubility in 2-propanol, acetone, 1-octanol, and acetonitrile.

Uses

Vonoprazan Fumarate (CAS# 881681-01-2) is a useful research chemical and a ATPase potassium-competitive acid blocker.

benefits

Compared with traditional irreversible proton pump inhibitors (such as omeprazole, esomeprazole, etc.), Vonoprazan fumarate advantages:
① The onset of action is good, and the maximum acid-suppressing effect will be achieved on the first day of administration;
② Oral administration, not affected by gastric acid damage;
③It can improve the phenomenon of acid breakthrough at night.

General Description

Vonoprazan fumarate (TAK-438) is a new oral anti-gastric acid drug jointly launched by Takeda Pharmaceutical and Otsuka Pharmaceutical. It can be used for the treatment of erosive esophagitis, gastric ulcer and duodenal ulcer.

Mechanism of action

Vonoprazan fumarate is a potassium ion (K+) competitive acid blocker (P-CAB), which is a reversible proton pump inhibitor. It can inhibit the combination of K+ and H+-K+-ATPase (proton pump), so that secretion of gastric acid is terminated. Vonoprazan fumarate has a strong and lasting inhibitory effect on gastric acid secretion.

Synthesis

Vonoprazan FuMarate is prepared by the reaction of vonoprazan and (2E)-but-2-enedioic acid. The steps are as follows:
Step 1: (2E)-but-2-enedioic acid With sodium hydroxide In water at 50 - 60℃.
Step 2: vonoprazan In water; toluene at 25 - 35℃; Reagent/catalyst.
Add 730g of water and 73g of fumaric acid to a 2L reaction flask at 5060, stir and disperse, control the temperature between 5060, add 25g of hydrogen hydroxide dropwise to the fumaric acid suspension The solution of sodium and 300 g of water was gradually dissolved in the system during the dropwise addition, and the aqueous solution of compound was obtained and kept for use.Between 25 and 35°C, take half of the toluene solution of compound obtained in the previous step and put it into a 5L reaction flask, and add the aqueous solution of the above compound dropwise to it. During the dropwise addition, the system has a white solid precipitation. After the dropwise addition was completed, keep stirring for 2-4 hours, filter, and dry the filter cake at 50°C to obtain 131.32 g of white solid, the HPLC purity was 99.96%, and the yield was 94%.

Vonoprazan FuMarate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vonoprazan FuMarate manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Vonoprazan fumarate,TAK-438,Takecab 881681-01-2
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99% HPLC
Supply Ability: 10000
Release date: 2024-09-21

shandong perfect biotechnology co.ltd

Product: Vonoprazan Fumarate 881681-01-2
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 1kg
Release date: 2023-08-03

Shaanxi Dideu Medichem Co. Ltd

Product: Vonoprazan FuMarate 881681-01-2
Price: US $1.00-1.00/Kg/Bag
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-30

881681-01-2, Vonoprazan FuMarateRelated Search:

1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 1-methylpyridin-1-ium-4-sulfonate 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Palbociclib 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Paroxetine PD0332991 Isethionate paroxetine Mesylate Esomeprazole R-(+)-Lansoprazole 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE Pantoprazole Lansoprazole Omeprazole Vonoprazan fumarate Vonoprazan

5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate

Vonoprazan FuMarate###NA

1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate

Vonoprazan-025-Salt1

Voranomazin

Vonoprazan FuMarate USP/EP/BP

Vonoprazan fumarate,TAK-438,Takecab

Vonoprazan fumarate 13C D3

Vonoprazan Fumurate

Fumarate vonorazan

5-(2- fluorophenyl) -N- methyl -1-(3- pyridylsulfonyl) -1H- pyrrole -3- methylamine fumarate

Vonoprazan FuMarat

Vonorazan Fumarate

1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate? (Vonoprazan Impurity）

5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate (1:1)

peptic,potassium,secretion,reflux,competitive,Vonoprazan Fumarate,proton,inhibitor,antisecretory,disease,gastroesophageal,inhibit,Vonoprazan,ulcer,GERD,blocker,acid,gastric,pump,P-CAB,Proton Pump

5-(2-Fluorophenyl)-N-methyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-methanamine fumarate (1:1)

TAK-438,Takecab

Vonoprazan Fumarate In-House

TAK 438 Fumarate

TAK438 Fumarate

TAK-438 Fumarate

881681-01-2