ChemicalBook > CAS DataBase List > Vonoprazan FuMarate

Vonoprazan FuMarate

Product Name: Vonoprazan FuMarate
CAS No.: 881681-01-2
Chemical Name: Vonoprazan FuMarate
Synonyms: Vonoprazan Fumurate;5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate;Voranomazin;TAK-438,Takecab;TAK438 Fumarate;TAK 438 Fumarate;TAK-438 Fumarate;Fumarate vonorazan;Vonoprazan FuMarat;Vonorazan Fumarate
CBNumber: CB52716735
Molecular Formula: C21H20FN3O6S
Formula Weight: 461.46
MOL File: 881681-01-2.mol

Less

Vonoprazan FuMarate Property

storage temp.: Store at -20°C
solubility: DMSO: 50 mg/mL (108.35 mM)
form: Solid
color: White to Off-White
InChIKey: ROGSHYHKHPCCJW-WLHGVMLRSA-N
SMILES: C(/C(=O)O)=C\C(=O)O.S(C1=CN=CC=C1)(N1C=C(CNC)C=C1C1C=CC=CC=1F)(=O)=O

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: V767013
Product name: VonoprazanFumarate
Packaging: 50mg
Price: $650
Updated: 2021/12/16

TRC

Product number: V767013
Product name: VonoprazanFumarate
Packaging: 5mg
Price: $95
Updated: 2021/12/16

ChemScene

Product number: CS-0746
Product name: Vonoprazan(Fumarate)
Purity: 99.94%
Packaging: 250mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0746
Product name: Vonoprazan(Fumarate)
Purity: 99.94%
Packaging: 500mg
Price: $170
Updated: 2021/12/16

Axon Medchem

Product number: Axon1971
Product name: TAK438
Purity: 98%
Packaging: 25mg
Price: $533.5
Updated: 2021/12/16

Less

Vonoprazan FuMarate Chemical Properties,Usage,Production

Chemical Properties

Vonoprazan fumarate is white to nearly white crystals or crystalline powder which melts at 194.8°C . It can be dissolved in dimethyl sulfoxide, but has limited solubility in N,N-dimethylacetamide, N,N-dimethylformamide, methanol, and water. It is only slightly soluble in ethanol (99.5%), and has very low solubility in 2-propanol, acetone, 1-octanol, and acetonitrile.

Uses

Vonoprazan Fumarate (CAS# 881681-01-2) is a useful research chemical and a ATPase potassium-competitive acid blocker.

benefits

Compared with traditional irreversible proton pump inhibitors (such as omeprazole, esomeprazole, etc.), Vonoprazan fumarate advantages:
① The onset of action is good, and the maximum acid-suppressing effect will be achieved on the first day of administration;
② Oral administration, not affected by gastric acid damage;
③It can improve the phenomenon of acid breakthrough at night.

General Description

Vonoprazan fumarate (TAK-438) is a new oral anti-gastric acid drug jointly launched by Takeda Pharmaceutical and Otsuka Pharmaceutical. It can be used for the treatment of erosive esophagitis, gastric ulcer and duodenal ulcer.

Mechanism of action

Vonoprazan fumarate is a potassium ion (K+) competitive acid blocker (P-CAB), which is a reversible proton pump inhibitor. It can inhibit the combination of K+ and H+-K+-ATPase (proton pump), so that secretion of gastric acid is terminated. Vonoprazan fumarate has a strong and lasting inhibitory effect on gastric acid secretion.

Synthesis

Vonoprazan FuMarate is prepared by the reaction of vonoprazan and (2E)-but-2-enedioic acid. The steps are as follows:
Step 1: (2E)-but-2-enedioic acid With sodium hydroxide In water at 50 - 60℃.
Step 2: vonoprazan In water; toluene at 25 - 35℃; Reagent/catalyst.
Add 730g of water and 73g of fumaric acid to a 2L reaction flask at 5060, stir and disperse, control the temperature between 5060, add 25g of hydrogen hydroxide dropwise to the fumaric acid suspension The solution of sodium and 300 g of water was gradually dissolved in the system during the dropwise addition, and the aqueous solution of compound was obtained and kept for use.Between 25 and 35°C, take half of the toluene solution of compound obtained in the previous step and put it into a 5L reaction flask, and add the aqueous solution of the above compound dropwise to it. During the dropwise addition, the system has a white solid precipitation. After the dropwise addition was completed, keep stirring for 2-4 hours, filter, and dry the filter cake at 50°C to obtain 131.32 g of white solid, the HPLC purity was 99.96%, and the yield was 94%.

Vonoprazan FuMarate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Vonoprazan FuMarate Suppliers

China 174 India 4 The Netherlands 1 United States 3 Global 182

Jiangsu Vcare PharmaTech Co., Ltd.

Tel: 025-58741518 13327700685
Fax: +86-25-58744115
Email: sales@vcarepharmatech.com
Country: China
ProdList: 308
Advantage: 61

ZHUHAI HRD PHARMACEUTICAL CO., LTD.

Tel: 0756-7737188 13326687259
Email: sales@hrdpharm.com
Country: China
ProdList: 123
Advantage: 58

CHENGHUI PHARMACEUTICAL GROUP LTD

Tel: 531-58897070 15254140813
Fax: 0531-58897046
Email: market@jnchsd.com
Country: China
ProdList: 236
Advantage: 58

Jinan Chenghui Shuangda biological Co., LTD

Tel: 0531-0531-58897003 15550412551
Fax: 0531-58897003
Email: market@jnchsd.com
Country: China
ProdList: 229
Advantage: 62

Shanghai Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: 021-58955996
Email: info@chemexpress.com
Country: China
ProdList: 819
Advantage: 58

Shandong Mingfeng Pharmaceutical and Technology Co. Ltd

Tel: -1345456643 15315114555
Fax: QQ:1345456643
Email: 1345456643@qq.com
Country: China
ProdList: 243
Advantage: 58

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 832
Advantage: 65

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2965
Advantage: 60

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Zhuhai Hauruide Bioscience and Technology Co., Ltd.

Tel: +86 756 3381619 0755-89456304
Email: antiall2006@163.com 55096841@qq.com
Country: China
ProdList: 50
Advantage: 58

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6468
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9287
Advantage: 55

Shanghai BLT Biological Pharmaceutical Co., Ltd.

Tel: 021-20786057 18918495077
Fax: 021-20786057
Email: 3116390381@qq.com
Country: China
ProdList: 220
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 2267
Advantage: 55

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29759
Advantage: 68

Hubei widely chemical technology Co., Ltd.

Tel: 027-83991130 18627774460
Fax: 027-83991130
Email: 1718093273@QQ.COM
Country: China
ProdList: 1676
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Zibo ChemYuan Pharmaceutical Co., Ltd.

Tel: 0533-2766162 13011630869
Fax: 0533-2766162
Email: zbchemyuan@163.com
Country: China
ProdList: 56
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1991
Advantage: 55

Wuhan Wsem Biological Co., Ltd.

Tel: 027-83778876 13667159345
Fax: 027-83778876
Email: 13667159345@163.com
Country: China
ProdList: 1999
Advantage: 55

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3932
Advantage: 58

Chemleader Biomedical Co., Limited.

Tel: 021-58180488
Fax: 021-58180499
Email: sales@MedChemLeader.com
Country: China
ProdList: 1006
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Porton Pharma Solutions Ltd.

Tel: 15169181595
Fax: 023860832006830
Email: ming.zhang3@portonpharma.com
Country: China
ProdList: 95
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd.

Tel: 0531-58897130 15508676053
Email: drug_impurity@sdcclh.com
Country: China
ProdList: 2268
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Yunfei Pharmaceutical(Shenzhen) Co., Ltd.

Tel: 0755-61160828 15994832653
Fax: 0755-61160828
Email: hulixiu@yunfeipharma.com
Country: China
ProdList: 252
Advantage: 58

Jinan Lide Pharmaceutical Technology Co., Ltd.

Tel: 0531-68654990 18560195202
Fax: 053168654990
Email: leadgxm@leadchem.net
Country: China
ProdList: 174
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10237
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Baoji Guokang Healthchem co.,ltd

Tel: +8615604608665 15604608665
Email: dominicguo@gk-bio.com
Country: CHINA
ProdList: 9414
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15107
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9989
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Wuhan Shuangjin Fine Chemical Co., Ltd.

Tel: 027-51903003 15926256169
Fax: 027-51903003
Email: 773164315@qq.com
Country: China
ProdList: 60
Advantage: 58

HubeiwidelychemicaltechnologyCo.,Ltd

Tel: 18627774460
Email: faith@widelychemical.com
Country: CHINA
ProdList: 742
Advantage: 58

Chengdu Feibo Pharm Technology Co., Ltd

Tel: +86 028-84641798 15982321820
Email: abby@arkpharm.com
Country: China
ProdList: 10000
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 10524
Advantage: 58

Less

View Lastest Price from Vonoprazan FuMarate manufacturers

Wuhan Biocar Pharmacy CO.,Ltd.

Product: Vonoprazan Fumarate 881681-01-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 900kg
Release date: 2025-03-03

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Vonoprazan fumarate,TAK-438,Takecab 881681-01-2
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99% HPLC
Supply Ability: 10000
Release date: 2024-09-21

shandong perfect biotechnology co.ltd

Product: Vonoprazan Fumarate 881681-01-2
Price: US $0.00/g
Min. Order: 1g
Purity: 98% HPLC
Supply Ability: 1kg
Release date: 2023-08-03

881681-01-2, Vonoprazan FuMarateRelated Search:

1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- 1-methylpyridin-1-ium-4-sulfonate 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate Palbociclib 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Paroxetine PD0332991 Isethionate paroxetine Mesylate Esomeprazole R-(+)-Lansoprazole 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE Pantoprazole Lansoprazole Omeprazole Vonoprazan fumarate Vonoprazan

5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate

Vonoprazan FuMarate###NA

1-(5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate

Vonoprazan-025-Salt1

Voranomazin

Vonoprazan FuMarate USP/EP/BP

Vonoprazan fumarate,TAK-438,Takecab

Vonoprazan fumarate 13C D3

Vonoprazan Fumurate

Fumarate vonorazan

5-(2- fluorophenyl) -N- methyl -1-(3- pyridylsulfonyl) -1H- pyrrole -3- methylamine fumarate

Vonoprazan FuMarat

Vonorazan Fumarate

5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine (2E)-2-butenedioate (1:1)

peptic,potassium,secretion,reflux,competitive,Vonoprazan Fumarate,proton,inhibitor,antisecretory,disease,gastroesophageal,inhibit,Vonoprazan,ulcer,GERD,blocker,acid,gastric,pump,P-CAB,Proton Pump

5-(2-Fluorophenyl)-N-methyl-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-methanamine fumarate (1:1)

TAK-438,Takecab

Vonoprazan Fumarate In-House

TAK 438 Fumarate

TAK438 Fumarate

TAK-438 Fumarate

1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate? (Vonoprazan Impurity）

D4-Vonoprazan Fumarate

881681-01-2